WITHDRAWN: Novel presentation of Plasmodium vivax malaria with acute kidney injury and hemolytic uremic syndrome

2016 ◽  
Author(s):  
Mohan P. Patel ◽  
Prakash P. Ugale ◽  
Abhijit B. Jagtap ◽  
Sandeep T. Chaudhary ◽  
Pitambar N. Dighore
Keyword(s):  
Acute Kidney Injury ◽  
Hemolytic Uremic Syndrome ◽  
Plasmodium Vivax ◽  
Vivax Malaria ◽  
Kidney Injury ◽  
Plasmodium Vivax Malaria ◽  
Uremic Syndrome

Novel presentation of Plasmodium vivax malaria with acute kidney injury and hemolytic uremic syndrome

2015 ◽  
Vol 4 (3-4) ◽  
pp. 34-37
Author(s):  
Mohan P. Patel ◽  
Prakash P. Ugale ◽  
Abhijeet B. Jagtap ◽  
Sandip T. Chaudhari ◽  
Pitambar N. Dighore
Keyword(s):  
Acute Kidney Injury ◽  
Hemolytic Uremic Syndrome ◽  
Plasmodium Vivax ◽  
Vivax Malaria ◽  
Kidney Injury ◽  
Plasmodium Vivax Malaria ◽  
Uremic Syndrome

A Study of Clinical Profile and Outcome in Adults with Plasmodium vivax Malaria

2020 ◽  
Vol 7 (43) ◽  
pp. 2470-2473
Author(s):  
Geetha Priyadarsini Kamminana ◽  
Jyotirmayi Boddu ◽  
Vasudev Rajapantula
Keyword(s):  
Acute Kidney Injury ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Plasmodium Vivax ◽  
Cerebral Malaria ◽  
Vivax Malaria ◽  
Distress Syndrome ◽  
Kidney Injury ◽  
Plasmodium Vivax Malaria

BACKGROUND Among malarial parasites, Plasmodium vivax is most prevalent in humans. Recent studies have shown severe and fatal complications with Plasmodium vivax infection. We wanted to evaluate the clinical spectrum, complications and outcomes of adult subjects with Plasmodium vivax malaria mono-infection. METHODS This is a retrospective study involving 100 subjects RESULTS Males were more commonly affected. It was most prevalent in the second decade of life. Fever was present in all patients. The other common symptoms were headache, vomiting, and jaundice. The incidence of associated clinical findings were pallor (43 %), icterus (21%), hepatomegaly (39 %) and splenomegaly (27 %). Severe thrombocytopenia was seen in 18 %, hyper bilirubinaemia in 39 % of subjects. Cerebral malaria was observed in 3 %, acute kidney injury in 13 %, ARDS (Acute Respiratory Distress Syndrome) in 5 % cases, MODS (Multi Organ Dysfunction Syndrome) was seen in 3 % cases, with a mortality of 3 %. CONCLUSIONS Complications like ARDS, AKI (Acute Kidney Injury), cerebral malaria and MODS were observed in benign tertian malaria subjects in our study. Cerebral malaria, AKI, MODS, ARDS were associated with high degrees of mortality. KEYWORDS Plasmodium vivax, ARDS (Acute Respiratory Distress Syndrome), Cerebral Malaria, AKI (Acute Kidney Injury), MODS (Multiorgan Dysfunction Syndrome)

scholarly journals Acute kidney injury in patients with Plasmodium vivax malaria: Clinicohistopathological profile

2016 ◽  
Vol 5 (3) ◽  
pp. 138 ◽  
Author(s):  
Kunal Gandhi ◽  
Piyush Kimmatkar ◽  
Rajesh Jhorawat ◽  
Rajesh Kumar ◽  
Vinay Malhotra ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Plasmodium Vivax ◽  
Vivax Malaria ◽  
Kidney Injury ◽  
Plasmodium Vivax Malaria

scholarly journals Plasmodium vivax malaria presenting as hemolytic uremic syndrome

2013 ◽  
Vol 23 (1) ◽  
pp. 74 ◽  
Author(s):  
MP Patel ◽  
VB Kute ◽  
MR Gumber ◽  
DN Gera ◽  
PR Shah ◽  
...  
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Plasmodium Vivax ◽  
Vivax Malaria ◽  
Plasmodium Vivax Malaria ◽  
Uremic Syndrome

Eculizumab Modifies Outcomes in Adults with Atypical Hemolytic Uremic Syndrome with Acute Kidney Injury

2018 ◽  
Vol 48 (3) ◽  
pp. 225-233 ◽  
Author(s):  
Mercedes Cao ◽  
Bruna N. Leite ◽  
Tamara Ferreiro ◽  
María Calvo ◽  
Constantino Fernández ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Hemolytic Uremic Syndrome ◽  
Kidney Function ◽  
Case Reports ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Kidney Injury ◽  
Complete Recovery ◽  
Genetic Abnormalities ◽  
Uremic Syndrome ◽  
Meta Analyses

Background: Atypical hemolytic uremic syndrome (aHUS) is a rare disease associated with congenital or acquired genetic abnormalities that result in uncontrolled complement activation, leading to thrombotic microangiopathy and kidney failure. Until recently, the only treatment was plasma exchange or plasma infusion (PE/PI), but 60% of patients died or had permanent kidney damage despite treatment. Eculizumab, a complement inhibitor, has shown promising results in aHUS. However, data are mainly extracted from case reports or studies of heterogeneous cohorts, and no direct comparison with PE/PI is available. Methods: An observational retrospective study of adult, dialysis-dependent aHUS patients with acute kidney injury (AKI) who were treated with either PE/PI alone or with second-line eculizumab in our center. We compared the effect of PE/PI and eculizumab on kidney function, hypertension, proteinuria, hematologic values, relapse, and death. Results: Thirty-one patients were included (females, 18; sporadic aHUS, 29; mean age, 46 ± 20 years). Twenty-six patients were treated with PE/PI alone, and 5 were deemed to be plasma-resistant and received eculizumab after stopping PE/PI. Among patients receiving eculizumab, 80% attained complete recovery of kidney function, 100% stopped dialysis, 20% had decreased proteinuria, and no patient relapsed (vs. 38.5, 50, 15.4, and 11.5%, respectively, of patients receiving only PE/PI). At 1-year of follow-up, no deaths had occurred in either group. Conclusion: Eculizumab shows greater efficacy than PE/PI alone for the treatment of adult aHUS patients with AKI. Prospective studies and meta-analyses are warranted to confirm our findings and set guidelines for treatment, monitoring, and maintenance.

scholarly journals Collapsing glomerulopathy and hemolytic uremic syndrome associated with falciparum malaria: completely reversible acute kidney injury

2012 ◽  
Vol 37 (2) ◽  
pp. 286-290 ◽  
Author(s):  
Vivek Balkrishna Kute ◽  
Hargovind L. Trivedi ◽  
Aruna V. Vanikar ◽  
Pankaj R. Shah ◽  
Manoj R. Gumber ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Hemolytic Uremic Syndrome ◽  
Falciparum Malaria ◽  
Kidney Injury ◽  
Collapsing Glomerulopathy ◽  
Uremic Syndrome
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