Ceanothane- and lupane-type triterpene esters from the roots of Hovenia dulcis and their antiproliferative activity on HSC-T6 cells

2017 ◽  
Vol 142 ◽  
pp. 60-67 ◽  
Author(s):  
Kyo Bin Kang ◽  
Jin Bum Jun ◽  
Jung Wha Kim ◽  
Hyun Woo Kim ◽  
Sang Hyun Sung
Keyword(s):  
Antiproliferative Activity ◽  
Hovenia Dulcis ◽  
Triterpene Esters

Water soluble palladium(ii) and platinum(ii) acyclic diaminocarbene complexes: solution behavior, DNA binding, and antiproliferative activity

2020 ◽  
Vol 44 (15) ◽  
pp. 5762-5773 ◽  
Author(s):  
Tatiyana V. Serebryanskaya ◽  
Mikhail A. Kinzhalov ◽  
Vladimir Bakulev ◽  
Georgii Alekseev ◽  
Anastasiya Andreeva ◽  
...  
Keyword(s):  
Dna Binding ◽  
Antiproliferative Activity ◽  
Water Soluble ◽  
Solution Behavior ◽  
Antitumor Potential ◽  
Acyclic Diaminocarbene

Water soluble Pd(ii) and Pt(ii)–ADC species synthesized via the metal-mediated coupling of isocyanides and 1,2-diaminobenzene have demonstrated antitumor potential.

In vitro and in vivo antiproliferative activity of arucanolide isolated from Calea pinnatifida

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
G Marchetti ◽  
K Silva ◽  
A Ruiz ◽  
I Sousa ◽  
S Tinti ◽  
...  
Keyword(s):  
Antiproliferative Activity

Selective antiproliferative activity of spinasterol from Physospemum verticillatum against A549 and COR-L23 cancer cells

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
R Tundis ◽  
B Deguin ◽  
MR Loizzo ◽  
M Bonesi ◽  
S Michel ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Antiproliferative Activity

Sesquiterpenes from Neurolaena lobata with antiproliferative activity

2017 ◽  
Author(s):  
A Vasas ◽  
I Lajter ◽  
P Forgó ◽  
N Kúsz ◽  
N Bózsity ◽  
...  
Keyword(s):  
Antiproliferative Activity

ESTABILIDADE FÍSICO-QUÍMICA DE PSEUDOFRUTOS FRESCOS E CONGELADOS DE UVA-DO-JAPÃO (Hovenia Dulcis Thunberg)

2012 ◽  
Vol 7 (1) ◽  
pp. 20
Author(s):  
Edilmar Piacentini Picolli ◽  
Dinéia Tessaro
Keyword(s):  
Hovenia Dulcis

A <em>Hovenia dulcis </em>é uma planta da família Rhamnaceae, popularmente conhecida como Uva-do-Japão. Seu fruto é apreciado por animais e humanos, além de apresentar potenciais ornamentais, artesanais, ecológicos, farmacológicos e industriais, embora seja ainda pouco explorada, uma vez que é mais conhecida pela população interiorana. O presente trabalho teve como objetivo avaliar as características físico-químicas de amostras frescas e congeladas por diferentes períodos de armazenagem da <em>Hovenia dulcis</em>. Foram avaliados os teores de ácido ascórbico, acidez total com determinação de ácidos orgânicos (málico, cítrico e tartárico), glicídios redutores em glicose, sólidos solúveis e pH da polpa da Uva-do-Japão. Os teores de ácido ascórbico, acidez total, ácidos málico, cítrico e tartárico foram maiores nas amostras frescas, passando por quedas gradativas ao longo das 5 semanas de armazenagem, enquanto que o pH, glicídios redutores em glicose, sólidos totais e solúveis apresentaram comportamento contrário, aumento ao longo do período de armazenagem.

The nootropic components of Hovenia dulcis

2010 ◽  
Vol 29 (11) ◽  
pp. 1281-1287
Author(s):  
Shu-zhen YI ◽  
Qiu-sheng FU
Keyword(s):  
Hovenia Dulcis

Synthesis, Characterization and Antiproliferative Activity Assessment of a Novel 1H-5-mercapto-1,2,4 Triazole Derivative

2017 ◽  
Vol 68 (4) ◽  
pp. 745-747 ◽  
Author(s):  
Marius Mioc ◽  
Sorin Avram ◽  
Vasile Bercean ◽  
Mihaela Balan Porcarasu ◽  
Codruta Soica ◽  
...  
Keyword(s):  
Antiproliferative Activity ◽  
Biological Activities ◽  
Cancer Cell Line ◽  
Vascular Endothelial ◽  
Triazole Derivative ◽  
Activity Assessment ◽  
Wide Range ◽  
Specific Receptors ◽  
Endothelial Growth Factor ◽  
Selection Of

Angiogenesis plays an important function in tumor proliferation, one of the main angiogenic promoters being the vascular endothelial growth factor (VEGF) which activates specific receptors, particularly VEGFR-2. Thus, VEGFR-2 has become an essential therapeutic target in the development of new antitumor drugs. 1,2,4-triazoles show a wide range of biological activities, including antitumor effect, which was documented by numerous reports. In the current study the selection of 5-mercapto-1,2,4-triazole structure (1H-3-styryl-5-benzylidenehydrazino-carbonyl-methylsulfanil-1,2,4-triazole, Tz3a.7) was conducted based on molecular docking that emphasized it as suitable ligand for VEGFR-2 and EGFR1 receptors. Compound Tz3a.7 was synthesized and physicochemically and biologically evaluated thus revealing a moderate antiproliferative activity against breast cancer cell line MDA-MB-231.

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