Studies of naturally occurring friedelane triterpenoids as insulin sensitizers in the treatment type 2 diabetes mellitus

2012 ◽  
Vol 84 ◽  
pp. 116-124 ◽  
Author(s):  
Alejandro E. Ardiles ◽  
Águeda González-Rodríguez ◽  
Marvin J. Núñez ◽  
Nayra R. Perestelo ◽  
Virginia Pardo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Naturally Occurring ◽  
Insulin Sensitizers ◽  
Treatment Type

scholarly journals Naturally Occurring Mutations in the Melanocortin Receptor 3 Gene Are Not Associated with Type 2 Diabetes Mellitus in French Caucasians1

2001 ◽  
Vol 86 (6) ◽  
pp. 2895-2898 ◽  
Author(s):  
El Habib Hani ◽  
Sophie Dupont ◽  
Emmanuelle Durand ◽  
Christian Dina ◽  
Sophie Gallina ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Melanocortin Receptor ◽  
Naturally Occurring

scholarly journals Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-10
Author(s):  
Nabajyoti Deka ◽  
Swapnil Bajare ◽  
Jessy Anthony ◽  
Amrutha Nair ◽  
Anagha Damre ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Type 2 Diabetes Mellitus ◽  
High Plasma ◽  
Insulin Sensitizers ◽  
Increased Risk

Metabolic syndrome is a widely prevalent multifactorial disorder associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. High plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic disorder. Thiazolidinediones (TZDs) are potent PPARγ ligand and used as insulin sensitizers in the treatment of type 2 diabetes mellitus. They are potent insulin-sensitizing agents but due to adverse effects like hepatotoxicity, a safer alternative of TZDs is highly demanded. Here we report synthesis of N-(6-(4-(piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide derivatives as an alternate remedy for insulin resistance.

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