Isolation, structure elucidation and biological activity of metabolites from Sch-642305-producing endophytic fungus Phomopsis sp. CMU-LMA

2011 ◽  
Vol 72 (18) ◽  
pp. 2406-2412 ◽  
Author(s):  
Emilie Adelin ◽  
Claudine Servy ◽  
Sylvie Cortial ◽  
Hélène Lévaique ◽  
Marie-Thérèse Martin ◽  
...  
Keyword(s):  
Biological Activity ◽  
Endophytic Fungus ◽  
Structure Elucidation

scholarly journals New Haloterpenes from the Marine Red Alga Laurencia papillosa: Structure Elucidation and Biological Activity

Marine Drugs ◽  
2021 ◽  
Vol 19 (1) ◽  
pp. 35
Author(s):  
Mohamed Shaaban ◽  
Ghada S. E. Abou-El-Wafa ◽  
Christopher Golz ◽  
Hartmut Laatsch
Keyword(s):  
Biological Activity ◽  
Crude Extract ◽  
Structure Elucidation ◽  
Antimicrobial Activities ◽  
Red Alga ◽  
Spectroscopic Methods ◽  
X Ray Diffraction ◽  
X Ray ◽  
Chemical Structures ◽  
Terpene Derivatives

Analysis of the air-dried marine red alga Laurencia papillosa, collected near Ras-Bakr at the Suez gulf (Red Sea) in Egypt delivered five new halogenated terpene derivatives: aplysiolic acid (1), 7-acetyl-aplysiol (2), aplysiol-7-one (3), 11,14-dihydroaplysia-5,11,14,15-tetrol (5a), and a new maneonene derivative 6, named 5-epi-maneolactone. The chemical structures of these metabolites were characterized employing spectroscopic methods, and the relative and absolute configurations were determined by comparison of experimental and ab initio-calculated NMR, NOE, ECD, and ORD data, and by X-ray diffraction of 2 and 6. The antimicrobial activities of the crude extract and compounds 1–3, 5a and 6 were studied.

scholarly journals Isolation, Structure Elucidation, and Biological Activity of a New Alkaloid from Zanthoxylum rhetsa

2011 ◽  
Vol 6 (11) ◽  
pp. 1934578X1100601
Author(s):  
Karsten Krohn ◽  
Stephan Cludius-Brandt ◽  
Barbara Schulz ◽  
Mambatta Sreelekha ◽  
Pottachola Mohamed Shafi
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid ◽  
Medicinal Plant ◽  
Plant Extract ◽  
Structure Elucidation ◽  
Biologically Active ◽  
Reduction Product ◽  
Pharmacological Properties ◽  
Evergreen Tree

Several biologically active alkaloids (1-4, 6), including a new quinazoline-6-carboxylic acid (1), were isolated from the medicinal plant Zanthoxylum rhetsa, an evergreen tree, native to subtropical areas. Whereas the pharmacological properties of the plant extract and single constituents have been widely tested, we now show that all of the metabolites have antialgal activities, all but 6 are antibacterial, and 6 and the reduction product 5 (derived from 4) are also antifungal.

scholarly journals A Comprehensive Review of the Structure Elucidation and Biological Activity of Triterpenoids from Ganoderma spp.

Molecules ◽  
2014 ◽  
Vol 19 (11) ◽  
pp. 17478-17535 ◽  
Author(s):  
Qing Xia ◽  
Huazheng Zhang ◽  
Xuefei Sun ◽  
Haijuan Zhao ◽  
Lingfang Wu ◽  
...  
Keyword(s):  
Biological Activity ◽  
Structure Elucidation ◽  
Comprehensive Review

Isolation, Structure Elucidation, and Biological Activity of the Steroid Oligoglycosides and Polyhydroxysteroids from the Antarctic StarfishAcodontaster conspicuus

1997 ◽  
Vol 60 (10) ◽  
pp. 959-966 ◽  
Author(s):  
Simona De Marino ◽  
Maria Iorizzi ◽  
Franco Zollo ◽  
Luigi Minale ◽  
Charles D. Amsler ◽  
...  
Keyword(s):  
Biological Activity ◽  
Structure Elucidation ◽  
The Antarctic

Val-Geninthiocin: Structure Elucidation and MSn Fragmentation of Thiopeptide Antibiotics Produced by Streptomyces sp. RSF18

2008 ◽  
Vol 63 (10) ◽  
pp. 1223-1230 ◽  
Author(s):  
Imran Sajid ◽  
Khaled A. Shaaban ◽  
Holm Frauendorf ◽  
Shahida Hasnain ◽  
Hartmut Laatscha
Keyword(s):  
Amino Acids ◽  
Biological Activity ◽  
Antifungal Activity ◽  
Structure Elucidation ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Unusual Amino Acids ◽  
Streptomyces Sp ◽  
Gram Positive Bacteria ◽  
Thiopeptide Antibiotics

AbstractVal-Geninthiocin (2), a new member of thiopeptide antibiotics, was isolated from the mycelium of Streptomyces sp. RSF18, along with the closely related geninthiocin (1) and the macrolide, chalcomycin. By intensive NMR and MS studies, Val-geninthiocin (2) was identified as desoxygeninthiocin, a thiopeptide, containing several oxazole and thiazole units and a number of unusual amino acids. Compound 2 shows potent activity against Gram-positive bacteria and minor antifungal activity, while it is not effective against Gram-negative bacteria or microalgae. Here we describe the fermentation, isolation and structure elucidation as well as the biological activity of 2.

scholarly journals Update on Monoterpenes from Red Macroalgae: Isolation, Analysis, and Bioactivity

Marine Drugs ◽  
2019 ◽  
Vol 17 (9) ◽  
pp. 537
Author(s):  
Ana-Marija Cikoš ◽  
Mladenka Jurin ◽  
Rozelindra Čož-Rakovac ◽  
Stela Jokić ◽  
Igor Jerković
Keyword(s):  
Biological Activity ◽  
Secondary Metabolites ◽  
Anticancer Activity ◽  
Structure Elucidation ◽  
Present Review ◽  
Red Macroalgae ◽  
Methylerythritol Phosphate ◽  
Halogenated Monoterpenes ◽  
Wide Range ◽  
Halogen Content

Macroalgae produce a wide range of monoterpenes as secondary metabolites of mevalonate (MVA) and/or methylerythritol phosphate (MEP) pathway (often including haloperoxidase action). Great biodiversity of macroalgal monoterpenes was reported including acyclic, monocyclic, and bicyclic structures. Halogenated monoterpenes exhibited significant biological activity (e.g., anticancer, antiplasmodial, and insecticidal) that is influenced by the number of present halogens (higher halogen content is preferable, especially bromine) and their position within the monoterpene skeleton. In distinction from the existing reviews, the present review provides novelty with respect to: (a) exclusively monoterpenes from red macroalgae are targeted; (b) biosynthesis, isolation, and analysis, as well as bioactivity of monoterpenes are represented; (c) the methods of their isolation, analysis, and structure elucidation are summarized; (d) the bioactivity of macroalgal monoterpenes is systematically presented with emphasis on anticancer activity; (e) the literature references were updated.

Isolation, Structure Elucidation, and Biological Activity of Maltepolides: Remarkable Macrolides from Myxobacteria

2013 ◽  
Vol 52 (20) ◽  
pp. 5402-5405 ◽  
Author(s):  
Herbert Irschik ◽  
Peter Washausen ◽  
Florenz Sasse ◽  
Jörg Fohrer ◽  
Volker Huch ◽  
...  
Keyword(s):  
Biological Activity ◽  
Structure Elucidation
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