Iridoid glycosides from Harpagophytum procumbens D.C. (devil’s claw)

2006 ◽  
Vol 67 (13) ◽  
pp. 1372-1377 ◽  
Author(s):  
Jin Qi ◽  
Ji-Jun Chen ◽  
Zhi-Hong Cheng ◽  
Jia-Hong Zhou ◽  
Bo-Yang Yu ◽  
...  
Keyword(s):  
Iridoid Glycosides ◽  
Devil’S Claw ◽  
Harpagophytum Procumbens

scholarly journals Harpagoside Content in Devil's Claw Extracts

2016 ◽  
Vol 11 (9) ◽  
pp. 1934578X1601100 ◽  
Author(s):  
Narasimharao Kondamudi ◽  
Matthew W. Turner ◽  
Owen M. McDougal
Keyword(s):  
Chemical Composition ◽  
High Performance ◽  
Iridoid Glycosides ◽  
Root Extract ◽  
Microwave Extraction ◽  
Root Extracts ◽  
Chromatography Analysis ◽  
Devil’S Claw ◽  
Harpagophytum Procumbens ◽  
Nutraceutical Products

Devil's claw is a common ingredient in nutraceutical products for the treatment of inflammation due to arthritis. The secondary root extract of Harpagophytum procumbens contains bioactive iridoid glycosides known as harpagosides. Recent scrutiny of the nutraceutical industry claims that products listing devil's claw on their labels should refer only to H. procumbens, while the closely related, and less expensive, H. zeyheri is not to be classified as devil's claw. This assertion is in contrast to botanists who claim that either species of Harpagophytum can be generically referred to as devil's claw. The current research aimed to determine the chemical composition of extracts from H. procumbens and H. zeyheri, with the intent to identify whether the bioactive harpagosides were similarly present between species, and how their presence resembled or deviated from commercially available H. procumbens extracts commonly used in nutraceutical products. A microwave extraction followed by high performance liquid chromatography analysis of root samples from botanical specimens of H. procumbens and H. zeyheri identified similar quantities of harpagoside, regardless of species. The chemical composition between root extracts for each species was found to contain varying quantities of non-harpagoside constituents, however their harpagoside content was comparable. These findings are intended to inform policymakers, nutraceutical manufacturers, and the general public of the distinction between myth and reality regarding devil's claw supplements.

scholarly journals Devil's claw (Harpagophytum procumbens) ameliorates the neurobehavioral changes and neurotoxicity in female rats exposed to arsenic

Heliyon ◽  
2020 ◽  
Vol 6 (5) ◽  
pp. e03921
Author(s):  
Rupasree Peruru ◽  
R. Usha Rani ◽  
Jhansyrani Thatiparthi ◽  
Sunitha Sampathi ◽  
Sujatha Dodoala ◽  
...  
Keyword(s):  
Female Rats ◽  
Devil’S Claw ◽  
Harpagophytum Procumbens

Devil's Claw—A review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens

2012 ◽  
Vol 143 (3) ◽  
pp. 755-771 ◽  
Author(s):  
Nontobeko Mncwangi ◽  
Weiyang Chen ◽  
Ilze Vermaak ◽  
Alvaro M. Viljoen ◽  
Nigel Gericke
Keyword(s):  
Biological Activity ◽  
Devil’S Claw ◽  
Harpagophytum Procumbens

scholarly journals DNA Barcode Authentication of Devil’s Claw Herbal Dietary Supplements

Plants ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2005
Author(s):  
Genelle L. Diaz-Silveira ◽  
Joan Deutsch ◽  
Damon P. Little
Keyword(s):  
United States ◽  
Confidence Interval ◽  
Dna Barcode ◽  
Pcr Amplification ◽  
Distinct Species ◽  
The United States ◽  
Herbal Supplement ◽  
Kalahari Desert ◽  
Devil’S Claw ◽  
Harpagophytum Procumbens

Devil’s claw is the vernacular name for a genus of medicinal plants that occur in the Kalahari Desert and Namibia Steppes. The genus comprises two distinct species: Harpagophytum procumbens and H. zeyheri. Although the European pharmacopeia considers the species interchangeable, recent studies have demonstrated that H. procumbens and H. zeyheri are chemically distinct and should not be treated as the same species. Further, the sale of H. zeyheri as an herbal supplement is not legal in the United States. Four markers were tested for their ability to distinguish H. procumbens from H. zeyheri: rbcL, matK, nrITS2, and psbA-trnH. Of these, only psbA-trnH was successful. A novel DNA mini-barcode assay that produces a 178-base amplicon in Harpagophytum (specificity = 1.00 [95% confidence interval = 0.80–1.00]; sensitivity = 1.00 [95% confidence interval = 0.75–1.00]) was used to estimate mislabeling frequency in a sample of 23 devil’s claw supplements purchased in the United States. PCR amplification failed in 13% of cases. Among the 20 fully-analyzable supplements: H. procumbens was not detected in 75%; 25% contained both H. procumbens and H. zeyheri; none contained only H. procumbens. We recommend this novel mini-barcode region as a standard method of quality control in the manufacture of devil’s claw supplements.

Devil's claw ( Harpagophytum procumbens ) and chronic inflammatory diseases: A concise overview on preclinical and clinical data

2019 ◽  
Vol 33 (9) ◽  
pp. 2152-2162 ◽  
Author(s):  
Luigi Menghini ◽  
Lucia Recinella ◽  
Sheila Leone ◽  
Annalisa Chiavaroli ◽  
Carla Cicala ◽  
...  
Keyword(s):  
Clinical Data ◽  
Inflammatory Diseases ◽  
Chronic Inflammatory Diseases ◽  
Concise Overview ◽  
Devil’S Claw ◽  
Harpagophytum Procumbens

scholarly journals Quality Assessment of Commercial Spagyric Tinctures of Harpagophytum procumbens and Their Antioxidant Properties

Molecules ◽  
2019 ◽  
Vol 24 (12) ◽  
pp. 2251 ◽  
Author(s):  
Pinarosa Avato ◽  
Maria Pia Argentieri
Keyword(s):  
Antioxidant Properties ◽  
Modern Medicine ◽  
Frap Assay ◽  
Main Compound ◽  
Devil’S Claw ◽  
Three Samples ◽  
Ic50 Value ◽  
Harpagophytum Procumbens ◽  
Chemical Fingerprinting ◽  
Ic50 Values

Preparations from the dried tubers of Harpagophytum procumbens (Burch.) DC ex Meisn, commonly known as devil’s claw, are mainly used in modern medicine to relieve joint pain and inflammation in patients suffering from rheumatic and arthritic disorders. This paper describes for the first time the chemical profile of a commercial spagyric tincture (named 019) prepared from the roots of the plant. For comparison purposes, a commercial not-spagyric devil’s claw tincture (NST) was also analyzed. Chemical investigation of the content of specialized metabolites in the three samples indicated that harpagoside was the main compound, followed by the two isomers acteoside and isoacteoside. Compositional consistence over time was obtained by the chemical fingerprinting of another spagyric tincture (named 014) from the same producer that was already expired according to the recommendation on the label of the product. The two spagyric preparations did not show significant compositional differences as revealed by HPLC and MS analyses, except for a decrease in harpagide content in the expired 014 tincture. Moreover, their antioxidant capacities as assessed by 2,2’-di-phenyl-1-picrylhydrazyl (DPPH) and 2.2’-azin-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) methods resulted in very similar IC50 values. The expired 014 tincture showed instead a lower IC50 value compared to the 019 and NST tinctures with the ferric reducing antioxidant potential (FRAP) assay, indicating a higher ferric-reducing antioxidant ability. Overall, these results indicated that the two preparations could generally maintain good stability and biological activity at least for the four years from the production to the expiration date.

scholarly journals Devil's claw (Harpagophytum procumbens) in a Brahman's preputial sheath : a case report from Botswana : case report

2001 ◽  
Vol 72 (1) ◽  
Author(s):  
J.F.W. Isa ◽  
S.R. Magembe ◽  
T.W. Naudé
Keyword(s):  
Case Report ◽  
Devil’S Claw ◽  
First Case ◽  
Tissue Dissection ◽  
Harpagophytum Procumbens ◽  
Dry Fruit

Failure of penile protrusion during attempted service of a cow on heat was investigated in a 3-year-old Brahman bull at Kwakwadi cattle-post in the Kgalahadi sandveld, Kweneng District, Botswana. The investigation revealed that penile protrusion was obstructed by a devil's claw (grapple thorn), a dry fruit of the plant Harpagophytum procumbens, which had lodged in the cavum preputiale. The thorn, which was removed almost completely manually with minimal tissue dissection, had also caused minor lacerations and puncture wounds on the lamina interna pars parietalis. The wounds healed well following treatment with antiseptics and antibiotics and subsequently the bull regained full penile protrusion and served the cows well. This report describes the first case of lodgement of a devil's claw fruit in, and its extraction from, the cavum preputiale of a Brahman.

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