Pro-nociceptive and anti-nociceptive effects of a conditioned pain modulation protocol in participants with chronic low back pain and healthy controls

Physiotherapy ◽  
2015 ◽  
Vol 101 ◽  
pp. e1247
Author(s):  
M. Rabey ◽  
C. Poon ◽  
J. Wray ◽  
C. Thamajaree ◽  
R. East ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Pain Modulation ◽  
Conditioned Pain Modulation ◽  
Healthy Controls ◽  
Low Back

Conditioned Pain Modulation in Chronic Low Back Pain

2020 ◽  
Vol 36 (2) ◽  
pp. 135-141
Author(s):  
Y. V. Raghava Neelapala ◽  
Madhura Bhagat ◽  
Laura Frey-Law
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Pain Modulation ◽  
Conditioned Pain Modulation ◽  
Low Back

scholarly journals Greater Conditioned Pain Modulation Is Associated With Enhanced Morphine Analgesia in Healthy Individuals and Patients With Chronic Low Back Pain

2020 ◽  
Vol 37 (1) ◽  
pp. 20-27
Author(s):  
Stephen Bruehl ◽  
Christopher R. France ◽  
Amanda L. Stone ◽  
Rajnish Gupta ◽  
Asokumar Buvanendran ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Pain Modulation ◽  
Conditioned Pain Modulation ◽  
Low Back ◽  
Morphine Analgesia ◽  
Healthy Individuals

scholarly journals Conditioned Pain Modulation in Patients With Acute and Chronic Low Back Pain

2016 ◽  
Vol 32 (2) ◽  
pp. 116-121 ◽  
Author(s):  
Sabine Mlekusch ◽  
Alban Y. Neziri ◽  
Andreas Limacher ◽  
Peter Jüni ◽  
Lars Arendt-Nielsen ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Pain Modulation ◽  
Conditioned Pain Modulation ◽  
Low Back

Prevalence of gluteus medius weakness in people with chronic low back pain compared to healthy controls

2015 ◽  
Vol 25 (4) ◽  
pp. 1258-1265 ◽  
Author(s):  
Nicholas A. Cooper ◽  
Kelsey M. Scavo ◽  
Kyle J. Strickland ◽  
Natti Tipayamongkol ◽  
Jeffrey D. Nicholson ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Gluteus Medius ◽  
Healthy Controls ◽  
Low Back

Acupuncture Treatment of Chronic Low Back Pain Reverses An Abnormal Brain Default Mode Network in Correlation with Clinical Pain Relief

2014 ◽  
Vol 32 (2) ◽  
pp. 102-108 ◽  
Author(s):  
Ji Li ◽  
Jun-Hai Zhang ◽  
Tao Yi ◽  
Wei-Jun Tang ◽  
Song-Wei Wang ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Prefrontal Cortex ◽  
Back Pain ◽  
Default Mode Network ◽  
Chronic Low Back Pain ◽  
Therapeutic Effects ◽  
Healthy Controls ◽  
Low Back ◽  
Default Mode ◽  
Clinical Pain

Background Acupuncture is gaining in popularity as a treatment for chronic low back pain (cLBP); however, its therapeutic mechanisms remain controversial, partly because of the absence of an objective way of measuring subjective pain. Resting-state functional MRI (rsfMRI) has demonstrated aberrant default mode network (DMN) connectivity in patients with chronic pain, and also shown that acupuncture increases DMN connectivity in pain-modulator and affective-emotional brain regions of healthy subjects. Objective This study sought to explore how cLBP influences the DMN and whether, and how, the altered DMN connectivity is reversed after acupuncture for clinical pain. Methods RsfMRI data from 20 patients with cLBP, before and after 4 weeks of treatment, and 10 age- and gender-matched healthy controls (without treatment) were analysed using independent components analyses to determine connectivity within the DMN, and combined with correlation analyses to compute covariance between changes in DMN connectivity and changes in clinical pain. Visual analogue scale data were assessed to rate clinical pain levels. Results Less connectivity within the DMN was found in patients with cLBP than in healthy controls, mainly in the dorsolateral prefrontal cortex, medial prefrontal cortex, anterior cingulate gyrus and precuneus. After acupuncture, patients’ connectivities were restored almost to the levels seen in healthy controls. Furthermore, reductions in clinical pain were correlated with increases in DMN connectivity. Conclusions This result suggests that modulation of the DMN by acupuncture is related to its therapeutic effects on cLBP. Imaging of the DMN provides an objective method for assessment of the effects of acupuncture-induced analgesia.

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