scholarly journals Effects of a glucagon-like peptide-1 analog on appetitive and consummatory behavior for rewarding and aversive gustatory stimuli in rats

2021 ◽  
Vol 229 ◽  
pp. 113279
Author(s):  
Joaquin E. Douton ◽  
Ralph Norgren ◽  
Patricia Sue Grigson
Keyword(s):  
Consummatory Behavior ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Central infusion of GLP-1, but not leptin, produces conditioned taste aversions in rats

1997 ◽  
Vol 272 (2) ◽  
pp. R726-R730 ◽  
Author(s):  
T. E. Thiele ◽  
G. Van Dijk ◽  
L. A. Campfield ◽  
F. J. Smith ◽  
P. Burn ◽  
...  
Keyword(s):  
Side Effects ◽  
Food Intake ◽  
Consummatory Behavior ◽  
Central Administration ◽  
Short Term ◽  
Nonspecific Effects ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Ob Protein

Leptin (ob protein) and glucagon-like peptide-1-(7-36) amide (GLP-1) are peptides recently proposed to be involved in the regulation of food intake. Although the ability of exogenous leptin and GLP-1 to modulate consummatory behavior is consistent with the suggestion that these peptides are endogenous regulatory agents, central administration of these peptides may have aversive side effects, which could explain the anorexia. In the present experiment, exposure to a saccharine taste was immediately followed by central administration of leptin or GLP-1 to determine if these drugs could produce a conditioned taste aversion (CTA) in rats. At doses equated for producing comparable reductions in short-term food intake, GLP-1, but not leptin, generated a robust CTA. Although leptin caused no aversion, this peptide was the only drug to cause relatively long-term reductions in food consumption (16 h) and body weight (24 h). Hence, the results indicate that central GLP-1 produces aversive side effects, and it is argued that these nonspecific effects may explain the anorectic actions of GLP-1.

Effects of glucagon-like peptide-1 (GLP-1) on gastric accommodation, emptying and satiety in humans

2001 ◽  
Vol 120 (5) ◽  
pp. A74-A74
Author(s):  
S AROS ◽  
D KIM ◽  
D BURTON ◽  
G THOMFORDE ◽  
A VELLA ◽  
...  
Keyword(s):  
Gastric Accommodation ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Eine häufige genetische Variation in WFS1 bedingt eine gestörte Glucagon-like Peptide-1-induzierte Insulinsekretion

2009 ◽  
Vol 4 (S 01) ◽  
Author(s):  
K Müssig ◽  
SA Schäfer ◽  
H Staiger ◽  
F Machicao ◽  
N Stefan ◽  
...  
Keyword(s):  
Genetische Variation ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Dulaglutide, a glucagon-like peptide-1 receptor agonist: in the search for survival molecule

2020 ◽  
Vol 9 (2) ◽  
pp. 49-58
Author(s):  
A.S. Ametov ◽  
◽  
A.O. Nevolnikova ◽  
E.A. Tertychnaya ◽  
O.A. Mishra ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Liraglutide, a glucagon-like peptide-1 receptor agonist, improves bone mass and architecture in ovariectomised mice

2014 ◽  
Author(s):  
Marie Pereira ◽  
Jeshmi Jeyabalan ◽  
Camilla Sofie Jorgensen ◽  
Mark Cleasby ◽  
Mark Hopkinson ◽  
...  
Keyword(s):  
Bone Mass ◽  
Receptor Agonist ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Effect of bariatric surgery on serum glucagon like peptide-1 concentration and metabolic parameters among obese type 2 diabetics

2013 ◽  
Author(s):  
Salah El Din Shelbaya ◽  
Alaa Abbas Mostafa ◽  
Salwa Seddik ◽  
Manal M. Abu Shady ◽  
Meram M. Bekhet ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Metabolic Parameters ◽  
Type 2 Diabetics ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1
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