scholarly journals Nociceptin/orphanin FQ neurons in the Arcuate Nucleus and Ventral Tegmental Area Act via Nociceptin Opioid Peptide Receptor Signaling to Inhibit Proopiomelanocortin and A10 Dopamine Neurons and Thereby Modulate Ingestion of Palatable Food

2021 ◽  
Vol 228 ◽  
pp. 113183
Author(s):  
Jennifer Hernandez ◽  
Lynnea Perez ◽  
Rosy Soto ◽  
Nikki Le ◽  
Cassandra Gastelum ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Arcuate Nucleus ◽  
Opioid Peptide ◽  
Dopamine Neurons ◽  
Receptor Signaling ◽  
Orphanin Fq ◽  
Palatable Food ◽  
Peptide Receptor ◽  
Ventral Tegmental

scholarly journals The food intake-suppressive effects of glucagon-like peptide-1 receptor signaling in the ventral tegmental area are mediated by AMPA/kainate receptors

2013 ◽  
Vol 305 (11) ◽  
pp. E1367-E1374 ◽  
Author(s):  
Elizabeth G. Mietlicki-Baase ◽  
Pavel I. Ortinski ◽  
Laura E. Rupprecht ◽  
Diana R. Olivos ◽  
Amber L. Alhadeff ◽  
...  
Keyword(s):  
Food Intake ◽  
Ventral Tegmental Area ◽  
Dopamine Neurons ◽  
Kainate Receptors ◽  
System Control ◽  
Receptor Signaling ◽  
Palatable Food ◽  
Glucagon Like Peptide ◽  
Ventral Tegmental ◽  
Glucagon Like Peptide 1

Glucagon-like peptide-1 receptor (GLP-1R) activation in the ventral tegmental area (VTA) is physiologically relevant for the control of palatable food intake. Here, we tested whether the food intake-suppressive effects of VTA GLP-1R activation are mediated by glutamatergic signaling within the VTA. Intra-VTA injections of the GLP-1R agonist exendin-4 (Ex-4) reduced palatable high-fat food intake in rats primarily by reducing meal size; these effects were mediated in part via glutamatergic AMPA/kainate but not NMDA receptor signaling. Additional behavioral data indicated that GLP-1R expressed specifically within the VTA can partially mediate the intake- and body weight-suppressive effects of systemically administered Ex-4, offering the intriguing possibility that this receptor population may be clinically relevant for food intake control. Intra-VTA Ex-4 rapidly increased tyrosine hydroxylase levels within the VTA, suggesting that GLP-1R activation modulates VTA dopaminergic signaling. Further evidence for this hypothesis was provided by electrophysiological data showing that Ex-4 increased the frequency of AMPA-mediated currents and reduced the paired/pulse ratio in VTA dopamine neurons. Together, these data provide novel mechanisms by which GLP-1R agonists in the mesolimbic reward system control for palatable food intake.

scholarly journals GABA Site Agonist Gaboxadol Induces Addiction-Predicting Persistent Changes in Ventral Tegmental Area Dopamine Neurons But Is Not Rewarding in Mice or Baboons

2012 ◽  
Vol 32 (15) ◽  
pp. 5310-5320 ◽  
Author(s):  
E. Vashchinkina ◽  
A. Panhelainen ◽  
O. Y. Vekovischeva ◽  
T. Aitta-aho ◽  
B. Ebert ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Dopamine Neurons ◽  
Ventral Tegmental

The Evolving Understanding of Dopamine Neurons in the Substantia Nigra and Ventral Tegmental Area

2018 ◽  
Vol 80 (1) ◽  
pp. 219-241 ◽  
Author(s):  
Stephanie C. Gantz ◽  
Christopher P. Ford ◽  
Hitoshi Morikawa ◽  
John T. Williams
Keyword(s):  
Substantia Nigra ◽  
Ventral Tegmental Area ◽  
Dopamine Neurons ◽  
Ventral Tegmental

scholarly journals Sensitization of Ventral Tegmental Area Dopamine Neurons to the Stimulating Effects of Ethanol

2009 ◽  
Vol 33 (9) ◽  
pp. 1571-1581 ◽  
Author(s):  
Zheng-Ming Ding ◽  
Zachary A. Rodd ◽  
Eric A. Engleman ◽  
William J. McBride
Keyword(s):  
Ventral Tegmental Area ◽  
Dopamine Neurons ◽  
Ventral Tegmental
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