The role of sleep disturbances in depressive-like behavior with emphasis on α-ketoglutarate dehydrogenase activity in rats.

2020 ◽  
Vol 224 ◽  
pp. 113023
Author(s):  
Parastou Kordestani-Moghadam ◽  
Mohammad Nasehi ◽  
Salar Vaseghi ◽  
Fariba Khodagholi ◽  
Mohammad-Reza Zarrindast
Keyword(s):  
Dehydrogenase Activity ◽  
Sleep Disturbances ◽  
Ketoglutarate Dehydrogenase

Decoding the Inter-relationship between Sleep Disorders and Alzheimer’s disease Pathogenesis

2020 ◽  
Vol 19 ◽  
Author(s):  
Zeba Mueed ◽  
Pankaj Kumar Rai ◽  
Mohammad A. Kamal ◽  
Nitesh Kumar Poddar
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Mammalian Target Of Rapamycin ◽  
Light Therapy ◽  
Paired Helical Filaments ◽  
Bidirectional Relationship ◽  
Causative Agents

Alzheimer’s disease (AD), characterized by abnormally phosphorylated tau, paired helical filaments (PHFs), neurofibrillary tangles (NFTs), deregulated mammalian target of rapamycin (mTOR), Aβ deposits, is a multifactorial disease with sleep disorders being one of the causative agents. Therefore, we have reviewed the literature and have tried to decode the existence of positive feedback, reciprocal and a bidirectional relationship allying between sleep disturbances and AD. Much light has been thrown on the role of tau pathology and amyloid pathology in sleep pathology and its association with AD pathology. We have also discussed the role of melatonin in regulating sleep disorders and AD. The neuroprotective action of melatonin via inhibiting tau hyperphosphorylation and Aβ deposition has also been pondered upon. Moreover, astrocytes involvement in aggravating AD has also been highlighted in this review. Several therapeutic approaches aimed at improving both sleep disorders and AD have been duly discussed such as administration of antidepressants and antihistamines, immunotherapy, metal chelators, melatonin supplementation, light therapy and physical activity. Despite consistent efforts, the complete etiology concerning sleep disorder and AD is still unclear. Therefore, further research is needed to unravel the mechanism involved and also to develop strategies that may help in obstructing AD in its preclinical stage.

Use of trypsin and lipoamidase to study the role of lipoic acid moieties in the pyruvate and .alpha.-ketoglutarate dehydrogenase complexes of Escherichia coli

Biochemistry ◽  
1981 ◽  
Vol 20 (16) ◽  
pp. 4555-4560 ◽  
Author(s):  
Larry R. Stepp ◽  
Dennis M. Bleile ◽  
Donald K. McRorie ◽  
Flora H. Pettit ◽  
Lester J. Reed
Keyword(s):  
Escherichia Coli ◽  
Lipoic Acid ◽  
Alpha Ketoglutarate Dehydrogenase ◽  
Ketoglutarate Dehydrogenase

scholarly journals Longitudinal Course and Risk Factors for Fatigue in Adolescents: The Mediating Role of Sleep Disturbances

2013 ◽  
Vol 38 (10) ◽  
pp. 1070-1080 ◽  
Author(s):  
See Wan Tham ◽  
Amy Lewandowski Holley ◽  
Chuan Zhou ◽  
Gregory N. Clarke ◽  
Tonya M. Palermo
Keyword(s):  
Risk Factors ◽  
Sleep Disturbances ◽  
Longitudinal Course ◽  
Mediating Role

scholarly journals Disparities in Sleep Health among Adolescents: The Role of Sex, Age, and Migration

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Maria Jose Miguez ◽  
Diego Bueno ◽  
Caroline Perez
Keyword(s):  
Sleep Disturbances ◽  
First Generation ◽  
Sleep Problems ◽  
Cultural Backgrounds ◽  
Use Of Technology ◽  
Sleep Debt ◽  
Adjusted Logistic Regression ◽  
Cultural Ecological ◽  
And Migration

Background. Disparities in sleep disturbances have been described in adults; nevertheless, among adolescents, data have yielded conflicting results. Therefore, analyses of our cohort study of 500 urban, normally developed Hispanic adolescents (10–18 years), aim to determine if rates of sleep debt differ between: (a) male and female adolescents, (b) US-born Hispanics and first-generation immigrant ethnic counterparts, and (c) specific activities that these teens trade for sleep. Participants’ weekday and weekend sleep patterns, along with the reasons for sleeping less than the recommended hours were recorded. Standardized surveys were used to gather information regarding sociodemographics, migration, acculturation, and medical history. Using the criteria set forth by the National Sleep Foundation, analyses indicated that sleep deprivation is a pervasive problem, with 75% in the preadolescents and 45% of the late adolescents exhibiting sleep problems. Females slept on average at least one hour less per day than their male counterparts (7 vs. 8 hours). The sleep problems were rooted in several overlapping causes, including use of technology, video games, studying, and employment. Nevertheless, reasons for sleep loss differed by gender and by immigrant status. Multivariable adjusted logistic regression analyses showed that females, US-born teens, and preadolescents had higher odds of being sleep deprived. Pediatricians and sleep experts should be aware of gender-specific causes and responses of sleep problems. Cultural ecological frameworks need to be considered, and clearly indicate that findings may not generalize to youth from other cultural backgrounds.

scholarly journals PATHOGENESIS OF FIBROMYALGIA IN PATIENTS WITH AUTOIMMUNE DISEASES: SCOPING REVIEW FOR HYPOTHESIS GENERATION

2020 ◽  
Vol 1 (1) ◽  
pp. 43-54
Author(s):  
Sakir Ahmed ◽  
Able Lawrence
Keyword(s):  
Rheumatic Diseases ◽  
Scoping Review ◽  
Sleep Disturbances ◽  
Unmet Needs ◽  
Social Defeat ◽  
Hypothesis Generation ◽  
Small Fibre Neuropathy ◽  
Small Fibre ◽  
The Common

Introduction: Fibromyalgia (FM) prevalence is much higher in patients with other rheumatic diseases than in the general population. This leads to increase in the perceived disease activity scores and prevents patients from reaching remission. Elucidating the pathogenesis of such “secondary” FM can help alleviate some unmet needs in these diseases. Methods: MEDLINE and Scopus databases were searched for a scoping review for hypothesis generation regarding the genesis of secondary FM. Results: FM has been postulated to be due to cytokine dysfunction, neurogenic neuroinflammation, stress, including social defeat, sleep disturbances, sympathetic overactivity, and small fibre neuropathy. These factors increase in most autoimmune and autoinflammatory diseases. Further the evidence for the role of these factors in the pathogenesis of FM is seems strong. Metabolic syndrome and mitochondrial dysfunction are also associated with FM, but it is difficult to distinguish between cause and effect. Conclusion: FM is the common phenotype arising from the amalgamation of various aetiologies. Recruitment or amplification of the above 6 factors by various rheumatic diseases may thus lead precipitation of secondary FM in susceptible individuals.

Correlates and Mediators of Dissociation: Towards a Transtheoretical Perspective

2020 ◽  
pp. 027623662095628
Author(s):  
Damla E. Aksen ◽  
Craig Polizzi ◽  
Steven Jay Lynn
Keyword(s):  
Negative Affect ◽  
Negative Correlation ◽  
Emotion Dysregulation ◽  
Sleep Disturbances ◽  
Significant Negative Correlation ◽  
Unique Variance ◽  
Positive Correlations ◽  
Bidirectional Relations ◽  
Mediational Role

We evaluated variables important to understanding dissociation ( N = 379 undergraduates). We investigated: (a) the correlations among dissociation and impulsivity, alexithymia, mindfulness, negative affect, neuroticism, sleep disturbances, and emotion dysregulation; (b) unique variance of these variables in statistically predicting dissociation scores; and (c) the statistical mediational role of emotion dysregulation and sleep in explaining dissociation. We found significant positive correlations between dissociation and emotion dysregulation, sleep, alexithymia, negative affect, impulsivity, and neuroticism as well as a significant negative correlation between mindfulness and dissociation, consistent with Lynn et al . Sleep, impulsivity, emotion dysregulation, and negative affect uniquely related to and explained significant variance in dissociation, in order from most to least variance accounted for. Sleep partially mediated the relation between emotion dysregulation and dissociation and the relation between impulsivity and dissociation. Emotion dysregulation partially mediated the relation between sleep and dissociation and the relation between impulsivity and dissociation. Additional findings provided support for bidirectional relations between sleep experiences and dissociation and emotion dysregulation and dissociation.

Sign in / Sign up

Export Citation Format

Share Document