scholarly journals Lateral hypothalamic area neuropeptides modulate ventral tegmental area dopamine neurons and feeding

2020 ◽  
Vol 223 ◽  
pp. 112986
Author(s):  
Patricia Perez-Bonilla ◽  
Krystal Santiago-Colon ◽  
Gina M. Leinninger
Keyword(s):  
Ventral Tegmental Area ◽  
Lateral Hypothalamic Area ◽  
Dopamine Neurons ◽  
Hypothalamic Area ◽  
Lateral Hypothalamic ◽  
Ventral Tegmental

scholarly journals Optogenetic stimulation of lateral hypothalamic orexin/dynorphin inputs in the ventral tegmental area potentiates mesolimbic dopamine neurotransmission and promotes reward-related behaviours

2020 ◽  
Author(s):  
Catherine S. Thomas ◽  
Madiha Rana ◽  
Min Qiao ◽  
Stephanie L. Borgland
Keyword(s):  
Ventral Tegmental Area ◽  
Real Time ◽  
Place Preference ◽  
Dopamine Neurons ◽  
Potential Contribution ◽  
Mesolimbic Dopamine ◽  
Optical Stimulation ◽  
Lateral Hypothalamic ◽  
Ventral Tegmental ◽  
Stimulation Of

ABSTRACTReward and reinforcement processes are critical for survival and propagation of genes. While numerous brain systems underlie these processes, a cardinal role is ascribed to mesolimbic dopamine. However, ventral tegmental area (VTA) dopamine neurons receive complex innervation and various neuromodulatory factors, including input from lateral hypothalamic orexin/hypocretin neurons which also express and co-release the neuropeptide, dynorphin (LHox/dyn). Dynorphin in the VTA induces aversive conditioning through the Kappa opioid receptor (KOR) and decreases dopamine when administered intra-VTA. Exogenous application of orexin or orexin 1 receptor (OXR1) antagonists in the VTA bidirectionally modulates dopamine-driven motivation and reward-seeking behaviours, including the attribution of motivational value to primary rewards and associated conditioned stimuli. However, the effect of endogenous stimulation of LHox/dyn-containing projections to the VTA and the potential contribution of co-released dynorphin on mesolimbic dopamine and reward related processes remains uncharacterised. We combined optogenetic, electrochemical, and behavioural approaches to examine this. We found that optical stimulation of LHox/dyn inputs in the VTA potentiates mesolimbic dopamine neurotransmission in the nucleus accumbens (NAc) core, produces real time and place preference, and increases the incentive value attributed to a Pavlovian food cue. LHox/dyn potentiation of NAc dopamine release and real time place preference was completely blocked by an OXR1 antagonist. Thus, rewarding effects associated with optical stimulation of LHox/dyn inputs in the VTA are predominantly driven by orexin rather than dynorphin.

scholarly journals Optogenetic stimulation of lateral hypothalamic orexin/dynorphin inputs in the ventral tegmental area potentiates mesolimbic dopamine neurotransmission and promotes reward-seeking behaviours

2021 ◽  
Author(s):  
Catherine S. Thomas ◽  
Aida Mohammadkhani ◽  
Madiha Rana ◽  
Min Qiao ◽  
Corey Baimel ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Real Time ◽  
Place Preference ◽  
Dopamine Neurons ◽  
Mesolimbic Dopamine ◽  
Optical Stimulation ◽  
Lateral Hypothalamic ◽  
Reward Seeking ◽  
Ventral Tegmental ◽  
Stimulation Of

AbstractReward and reinforcement processes are critical for survival and propagation of genes. While numerous brain systems underlie these processes, a cardinal role is ascribed to mesolimbic dopamine. However, ventral tegmental area (VTA) dopamine neurons receive complex innervation and various neuromodulatory factors, including input from lateral hypothalamic (LH) orexin/hypocretin neurons which also express and co-release the neuropeptide, dynorphin. Dynorphin in the VTA induces aversive conditioning through the Kappa opioid receptor (KOR) and decreases dopamine when administered intra-VTA. Exogenous application of orexin or orexin 1 receptor (oxR1) antagonists in the VTA bidirectionally modulates dopamine-driven motivation and reward-seeking behaviours, including the attribution of motivational value to primary rewards and associated conditioned stimuli. However, the effect of endogenous stimulation of LH orexin/dynorphin-containing projections to the VTA and the potential contribution of co-released dynorphin on mesolimbic dopamine and reward related processes remains uncharacterised. We combined optogenetic, electrochemical, and behavioural approaches to examine this. We found that optical stimulation of LH orexin/dynorphin inputs in the VTA potentiates mesolimbic dopamine neurotransmission in the nucleus accumbens (NAc) core, produces real time and conditioned place preference, and increases the food cue-directed orientation in a Pavlovian conditioning procedure. LH orexin/dynorphin potentiation of NAc dopamine release and real time place preference was blocked by an oxR1, but not KOR antagonist. Thus, rewarding effects associated with optical stimulation of LH orexin/dynorphin inputs in the VTA are predominantly driven by orexin rather than dynorphin.

Alteration of the expression of the hypocretin (orexin) gene by 2-deoxyglucose in the rat lateral hypothalamic area

Neuroreport ◽  
2000 ◽  
Vol 11 (3) ◽  
pp. 531-533 ◽  
Author(s):  
Laurence Bayer ◽  
Claude Colard ◽  
Nhu Uyen Nguyen ◽  
Pierre-Yves Risold ◽  
Dominique Fellmann ◽  
...  
Keyword(s):  
Lateral Hypothalamic Area ◽  
Hypothalamic Area ◽  
Lateral Hypothalamic

scholarly journals GABA Site Agonist Gaboxadol Induces Addiction-Predicting Persistent Changes in Ventral Tegmental Area Dopamine Neurons But Is Not Rewarding in Mice or Baboons

2012 ◽  
Vol 32 (15) ◽  
pp. 5310-5320 ◽  
Author(s):  
E. Vashchinkina ◽  
A. Panhelainen ◽  
O. Y. Vekovischeva ◽  
T. Aitta-aho ◽  
B. Ebert ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Dopamine Neurons ◽  
Ventral Tegmental
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