Adverse Childhood Experiences and Adult Obesity: A Systematic Review of Plausible Mechanisms and Meta-Analysis of Cross-Sectional Studies

2020 ◽  
Vol 223 ◽  
pp. 112964 ◽  
Author(s):  
David A. Wiss ◽  
Timothy D. Brewerton
Keyword(s):  
Systematic Review ◽  
Adverse Childhood Experiences ◽  
Meta Analysis ◽  
Adult Obesity ◽  
Cross Sectional ◽  
Childhood Experiences ◽  
Adverse Childhood ◽  
Cross Sectional Studies

Adverse childhood experiences and risk of cancer during adulthood: A systematic review and meta-analysis

2021 ◽  
Vol 117 ◽  
pp. 105088
Author(s):  
Zhao Hu ◽  
Atipatsa Chiwanda Kaminga ◽  
Jun Yang ◽  
Jiefeng Liu ◽  
Huilan Xu
Keyword(s):  
Systematic Review ◽  
Adverse Childhood Experiences ◽  
Meta Analysis ◽  
Childhood Experiences ◽  
Adverse Childhood ◽  
Risk Of Cancer

Adverse childhood experiences and risk of type 2 diabetes: A systematic review and meta-analysis

Metabolism ◽  
2015 ◽  
Vol 64 (11) ◽  
pp. 1408-1418 ◽  
Author(s):  
Hao Huang ◽  
Peipei Yan ◽  
Zhilei Shan ◽  
Sijing Chen ◽  
Moying Li ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Adverse Childhood Experiences ◽  
Meta Analysis ◽  
Childhood Experiences ◽  
Adverse Childhood

scholarly journals Adverse childhood experiences and chronic lung diseases in adulthood: a systematic review and meta-analysis

2020 ◽  
Vol 11 (1) ◽  
pp. 1720336 ◽  
Author(s):  
Samuel Lopes ◽  
Jaime Eduardo Cecilio Hallak ◽  
João Paulo Machado de Sousa ◽  
Flávia de Lima Osório
Keyword(s):  
Systematic Review ◽  
Adverse Childhood Experiences ◽  
Lung Diseases ◽  
Meta Analysis ◽  
Childhood Experiences ◽  
Chronic Lung Diseases ◽  
Adverse Childhood

scholarly journals Relationship between adverse childhood experiences and Alzheimer’s disease: a systematic review and meta-analysis protocol

BMJ Open ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. e049768
Author(s):  
Kayla B Corney ◽  
Julie A Pasco ◽  
Amanda L Stuart ◽  
Emma C West ◽  
Shae E Quirk ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Adverse Childhood Experiences ◽  
Meta Analysis ◽  
Population Exposure ◽  
Published Data ◽  
Childhood Experiences ◽  
Substantial Impact ◽  
Adverse Childhood

IntroductionAlzheimer’s disease has a high prevalence and a substantial impact on society, as well as the individual. Findings from clinical studies to date, suggest that multiple factors are likely to contribute to the variability seen in the progression of Alzheimer’s disease. However, despite this accumulating evidence, current identified factors do not explain the full extent of disease onset. Thus, the role of additional factors needs to be explored further.One such factor is exposure to adverse childhood experiences. However, the degree of this association is unknown. This systematic review will examine the literature investigating the associations between adverse childhood experiences and the risk of Alzheimer’s disease.Methods and analysisArticles investigating associations between exposure to adverse childhood experiences and the risk of Alzheimer’s disease will be identified systematically by searching CINAHL, MEDLINE and PsycInfo using Ebscohost. No restrictions on date of publication will be applied. The search strategy will be built combining the main key elements of the Population, Exposure, Comparator, and Outcomes inclusion criteria. A meta-analysis is planned and statistical methods will be used to identify and control for heterogeneity, if possible. The development of this protocol was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols.Ethics and disseminationOnly published data will be used for this study, thus, ethical approval will not be required. Findings of the review will be published in a peer-reviewed scientific journal, and presented at national and international conferences.PROSPERO registration numberCRD42020191439.

scholarly journals Adverse childhood experience and adult persistent pain and disability: protocol for a systematic review and meta-analysis

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
André Bussières ◽  
Jan Hartvigsen ◽  
Manuela L. Ferreira ◽  
Paulo H. Ferreira ◽  
Mark J. Hancock ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adverse Childhood Experiences ◽  
Emotional Abuse ◽  
Meta Analysis ◽  
Well Being ◽  
Persistent Pain ◽  
Eligibility Criteria ◽  
Childhood Experiences ◽  
Mesh Terms ◽  
Adverse Childhood

Abstract Background A growing body of research highlights the pervasive harms of adverse childhood experiences (ACEs) on health throughout the life-course. However, findings from prior reviews and recent longitudinal studies investigating the association between types of ACEs and persistent pain have yielded inconsistent findings in the strength and direction of associations. The purpose of this review is to appraise and summarize evidence on the relationship between ACEs and persistent pain and disability outcomes in adulthood. The specific aims are (1) to determine whether there is a relationship between exposure to ACE and persistent pain and disability in adults and (2) to determine whether unique and cumulative ACEs exposures (number and type) increase the risk of developing persistent pain and disability in adulthood. Method A systematic review and meta-analysis of observational studies will be conducted. Our eligibility criteria are defined following a PECOS approach: population, adults with persistent (≥ 3 months) musculoskeletal and somatoform painful disorders exposed to single or cumulative direct ACEs alone (i.e., physical, sexual, emotional abuse or neglect) or in combination to indirect types of ACE (e.g., parental death, exposure to domestic violence) in the first 18 years of life; comparators, unexposed individuals; outcomes, measurements for persistent pain (≥ 3 months) and disability using discrete and/or continuous measures; and settings, general population, primary care. A comprehensive search of MEDLINE (Ovid) and nine other pertinent databases was conducted from inception to 29 August 2019 using a combination of key words and MeSh terms (the search will be updated prior to conducting the analyses). Pairs of reviewers will independently screen records and full text articles, and a third reviewer will be consulted in cases of disagreement. Data will be extracted using Endnote and Covidence and a meta-analysis will be conducted using Review Manager (RevMan) Version 5.3. The Scottish Intercollegiate Guidelines Network (SIGN) and the Joanna Briggs Institute (JBI) checklists will be used to assess the quality of the included studies. If heterogeneity is high, the findings will be presented in narrative form. Discussion The present review will help consolidate knowledge on persistent pain and disability by evaluating whether frequency and type of adverse childhood experiences produces the most harm. Findings may help inform practitioners and policy-makers who endeavor to prevent and/or mitigate the consequences of ACEs and promote healthy development and well-being of children, youth, and families. Systematic review registration PROSPERO CRD42020150230

scholarly journals The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis

2017 ◽  
Vol 2 (8) ◽  
pp. e356-e366 ◽  
Author(s):  
Karen Hughes ◽  
Mark A Bellis ◽  
Katherine A Hardcastle ◽  
Dinesh Sethi ◽  
Alexander Butchart ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adverse Childhood Experiences ◽  
Meta Analysis ◽  
Childhood Experiences ◽  
Adverse Childhood

scholarly journals Adverse Childhood Experiences Are Associated with Reduced Psychological Resilience in Youth: A Systematic Review and Meta-Analysis

Children ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 27
Author(s):  
Cyleen A. Morgan ◽  
Yun-Hsuan Chang ◽  
Olivia Choy ◽  
Meng-Che Tsai ◽  
Shulan Hsieh
Keyword(s):  
Systematic Review ◽  
Health Outcomes ◽  
Adverse Childhood Experiences ◽  
Meta Analysis ◽  
Negative Association ◽  
Psychological Resilience ◽  
Childhood Experiences ◽  
Adverse Childhood ◽  
The Relationship ◽  
Negative Health Outcomes

Background: Adverse childhood experiences (ACEs) are presumed to influence internalizing and externalizing behaviors that can significantly debilitate long-term biopsychological development in individuals. Psychological resilience has been shown to effectively mediate the relationship between ACEs and negative health outcomes since individuals with low levels of resilience may have difficulty with bouncing back from toxic exposure to ACEs. Thus, the present systematic review and meta-analysis was aimed toward synthesizing current knowledge of the relationship between ACEs and psychological resilience in youths. Methods: A combination of key words relevant to the present study was searched on the PubMed, EMBASE, Scopus, Cochrane, and Google Scholar databases. The results were restricted to English publications and human studies, with subjects ranging between the age of 0 to 35 years. Effect-size measures inclusive of pooled correlation coefficients for correlation analyses and pooled odds ratios for regression analyses, respectively, were calculated using random-effect models to determine the relationship between ACEs and psychological resilience. Results: The searches identified 85 potentially relevant studies. Among them, 76 were excluded due to limited access, irrelevant data, and the fact that the variables of interest were not explicitly measured or disclosed, leaving a final total of nine studies considered valid for the meta-analysis. Findings from correlational meta-analysis (n = 6) revealed a significantly negative association between ACEs and resilience (β = −0.120 [−0.196, −0.043]). The meta-analysis of the studies (n = 3) reporting dichotomous outcomes (ACE ≥ 1 vs. no ACE) indicated that subjects who experienced an ACE were 63% less likely to display high resilience, in comparison to subjects without such experiences. Conclusion: Our results support a negative association between ACEs and psychological resilience and highlight the multiple dimensions that constitute resilience in an ACE-exposure context. These findings may be particularly useful to policy makers and healthcare institutions in terms of helping them devise effective medical interventions and community outreach programs intended to develop resilience in youths, thus reducing health-risk behaviors and negative health outcomes.

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