Brief but enough: 45-min maternal separation elicits behavioral and physiological responses in neonatal mice and changes in dam maternal behavior

2020 ◽  
Vol 222 ◽  
pp. 112877
Author(s):  
O.V. Burenkova ◽  
A.A. Averkina ◽  
E.A. Aleksandrova ◽  
I.Yu. Zarayskaya
Keyword(s):  
Maternal Behavior ◽  
Maternal Separation ◽  
Physiological Responses ◽  
Neonatal Mice

Behavioral and physiological responses to maternal separation in squirrel monkeys (Saimiri sciureus).

1990 ◽  
Vol 104 (1) ◽  
pp. 108-115 ◽  
Author(s):  
Sandra G. Wiener ◽  
Francoise Bayart ◽  
Kym F. Faull ◽  
Seymour Levine
Keyword(s):  
Maternal Separation ◽  
Physiological Responses ◽  
Squirrel Monkeys ◽  
Saimiri Sciureus

scholarly journals Maternal separation in rats induces neurobiological and behavioral changes on the maternal side

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ibrahim Bölükbas ◽  
Annakarina Mundorf ◽  
Nadja Freund
Keyword(s):  
Maternal Behavior ◽  
High Performance ◽  
Maternal Separation ◽  
Serum Levels ◽  
Sensitive Period ◽  
Plus Maze ◽  
Marble Burying ◽  
Postpartum Stress ◽  
Glucocorticoid Receptor Mrna ◽  
Peripheral Markers

AbstractThe time after parturition is a sensitive period for mothers where they are prone to develop psychopathological symptoms. Studies investigating dams after separation from their pups (maternal separation, MS) showed that MS induces alterations similar to postpartum depression. This study aims to give further details on affected behavior and neurobiology of dams after MS. MS in rats from postnatal day 2–20 over four hours daily was performed. Upon reunion, maternal behavior, and ultrasonic vocalization (USV) of dams were measured. On the day of weaning, dams were tested for anxiety-like behavior in the elevated-plus-maze and marble burying test. Then Morc1 mRNA in the medial prefrontal cortex and Nr3c1 encoding the glucocorticoid receptor mRNA in the hippocampus were measured using real-time PCR to examine possible neurobiological correlates in psychopathology and social behavior. GABA and glutamate serum levels were analyzed by high-performance liquid chromatography as peripheral markers for stress-induced psychopathology. MS in dams increased maternal care towards pups even though both groups show high levels of maternal behavior even in late lactation. Furthermore, the emission of 50-kHz and 22-kHz USVs increased significantly. No differences in anxiety-like behavior were detected. MS further reduced Morc1 but not Nr3c1 expression. Serum GABA but not glutamate levels were significantly increased in separated dams. This study reinforces the benefit of investigating dams after MS for studying postpartum stress. Subclinical markers mainly connected to depression, namely Morc1 and GABA, proved to be useful allowing for earlier detection of symptoms of critical postpartum stress.

scholarly journals Maternal behavior of the mouse dam toward pups: implications for maternal separation model of early life stress

Stress ◽  
2017 ◽  
Vol 21 (1) ◽  
pp. 19-27 ◽  
Author(s):  
Rodrigo Orso ◽  
Luis Eduardo Wearick-Silva ◽  
Kerstin Camile Creutzberg ◽  
Anderson Centeno-Silva ◽  
Laura Glusman Roithmann ◽  
...  
Keyword(s):  
Maternal Behavior ◽  
Life Stress ◽  
Early Life ◽  
Maternal Separation ◽  
Early Life Stress ◽  
Separation Model

scholarly journals Effects of Perinatal Stress and Drug Abuse on Maternal Behavior and Sensorimotor Development of Affected Progeny

2017 ◽  
pp. S481-S491 ◽  
Author(s):  
A. HOLUBOVÁ ◽  
M. ŠEVČÍKOVÁ ◽  
E. MACÚCHOVÁ ◽  
I. HREBÍČKOVÁ ◽  
M. POMETLOVÁ ◽  
...  
Keyword(s):  
Water Stress ◽  
Maternal Behavior ◽  
Maternal Separation ◽  
Cold Water ◽  
Prenatally Exposed ◽  
Sensorimotor Development ◽  
Pup Retrieval ◽  
Righting Reflex ◽  
Delayed Development ◽  
Postnatal Stress

Methamphetamine (MA) is an addictive psychostimulant with significant potential for abuse. Previous rat studies have demonstrated that MA use during pregnancy impairs maternal behavior and induced delayed development of affected pups. The offspring of drug-addictive mothers were often neglected and exposed to neonatal stressors. The present study therefore examines the effect of perinatal stressors combined with exposure to prenatal MA on the development of pups and maternal behavior. Dams were divided into three groups according to drug treatment during pregnancy: controls (C); saline (SA, s.c., 1 ml/kg); MA (s.c., 5 mg/ml/kg). Litters were divided into four groups according to postnatal stressors: controls (N); maternal separation (S); maternal cold-water stress (W); maternal separation plus cold-water stress (SW). The pup-retrieval test showed differences among postnatally stressed mothers and non-stressed controls. The righting reflex on a surface revealed delayed development of pups prenatally exposed to MA/SA and postnatal stress. Negative geotaxis and Rotarod results confirmed that the MA group was the most affected. Overall, our data suggests that a combination of perinatal stress and prenatal MA can have a detrimental effect on maternal behavior as well as on the sensorimotor development of pups. However, MA exposure during pregnancy seems to be the decisive factor for impairment.

Brief and long periods of maternal separation affect maternal behavior and offspring behavioral development in C57BL/6 mice

2013 ◽  
Vol 56 (4) ◽  
pp. 674-685 ◽  
Author(s):  
Jeremy D. Bailoo ◽  
Richard L. Jordan ◽  
Xavier J. Garza ◽  
Amber N. Tyler
Keyword(s):  
Maternal Behavior ◽  
Maternal Separation ◽  
Behavioral Development

scholarly journals Genetic Regulation of Maternal Oxytocin Response and Its Influences on Maternal Behavior

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Divya Mehta ◽  
Valsamma Eapen ◽  
Jane Kohlhoff ◽  
Antonio Mendoza Diaz ◽  
Bryanne Barnett ◽  
...  
Keyword(s):  
Risk Score ◽  
Maternal Behavior ◽  
Genetic Risk ◽  
Maternal Separation ◽  
Separation Anxiety ◽  
Genetic Risk Score ◽  
Genetic Regulation ◽  
Maternal Sensitivity ◽  
Free Play ◽  
Maternal Separation Anxiety

We interrogated the genetic modulation of maternal oxytocin response and its association with maternal behavior using genetic risk scores within the oxytocin receptor (OXTR) gene. We identified a novel SNP, rs968389, to be significantly associated with maternal oxytocin response after a challenging mother-infant interaction task (Still Face Paradigm) and maternal separation anxiety from the infant. Performing a multiallelic analysis across OXTR by calculating a cumulative genetic risk score revealed a significant gene-by-environment (G×E) interaction, with OXTR genetic risk score interacting with adult separation anxiety to modulate levels of maternal sensitivity. Mothers with higher OXTR genetic risk score and adult separation anxiety showed significantly reduced levels of maternal sensitivity during free play with the infant. The sameG×Einteraction was also observed for the extended OXTR cumulative genetic risk score that included rs968389. Moreover, the extended cumulative OXTR genetic risk score itself was found to be significantly associated with maternal separation anxiety as it specifically relates to the infant. Our results suggest a complex montage of individual and synergistic genetic mediators of maternal behavior. These findings add to specific knowledge about genetic regulation of maternal oxytocin response in relation to maternal adjustment and infant bonding through the first few months of life.

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