Behavioral abnormalities and phosphorylation deficits of extracellular signal-regulated kinases 1 and 2 in rat offspring of the maternal immune activation model

2020 ◽  
Vol 217 ◽  
pp. 112805
Author(s):  
Wenqiang Li ◽  
Fuping Sun ◽  
Xiaoge Guo ◽  
Yunqing Hu ◽  
Shuang Ding ◽  
...  
Keyword(s):  
Immune Activation ◽  
Activation Model ◽  
Maternal Immune Activation ◽  
Rat Offspring ◽  
Behavioral Abnormalities ◽  
Extracellular Signal

Impaired discrimination of a subanesthetic dose of ketamine in a maternal immune activation model of schizophrenia risk

2021 ◽  
pp. 026988112110297
Author(s):  
Wayne Meighan ◽  
Thomas W Elston ◽  
David Bilkey ◽  
Ryan D Ward
Keyword(s):  
Animal Models ◽  
Drug Discrimination ◽  
Immune Activation ◽  
Internal State ◽  
Nmda Receptor Antagonist ◽  
Activation Model ◽  
Data Link ◽  
Maternal Immune Activation ◽  
Internal States ◽  
Reliable Methods

Background: Animal models of psychiatric diseases suffer from a lack of reliable methods for accurate assessment of subjective internal states in nonhumans. This gap makes translation of results from animal models to patients particularly challenging. Aims/methods: Here, we used the drug-discrimination paradigm to allow rats that model a risk factor for schizophrenia (maternal immune activation, MIA) to report on the subjective internal state produced by a subanesthetic dose of the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine. Results/outcomes: The MIA rats’ discrimination of ketamine was impaired relative to controls, both in the total number of rats that acquired and the asymptotic level of discrimination accuracy. This deficit was not due to a general inability to learn to discriminate an internal drug cue or internal state generally, as MIA rats were unimpaired in the learning and acquisition of a morphine drug discrimination and were as sensitive to the internal state of satiety as controls. Furthermore, the deficit was not due to a decreased sensitivity to the physiological effects of ketamine, as MIA rats showed increased ketamine-induced locomotor activity. Finally, impaired discrimination of ketamine was only seen at subanesthetic doses which functionally correspond to psychotomimetic doses in humans. Conclusion: These data link changes in NMDA responses to the MIA model. Furthermore, they confirm the utility of the drug-discrimination paradigm for future inquiries into the subjective internal state produced in models of schizophrenia and other developmental diseases.

scholarly journals Changes in Astroglial Markers in a Maternal Immune Activation Model of Schizophrenia in Wistar Rats are Dependent on Sex

2015 ◽  
Vol 9 ◽  
Author(s):  
Daniela F. de Souza ◽  
Krista M. Wartchow ◽  
Paula S. Lunardi ◽  
Giovana Brolese ◽  
Lucas S. Tortorelli ◽  
...  
Keyword(s):  
Immune Activation ◽  
Wistar Rats ◽  
Activation Model ◽  
Maternal Immune Activation

NOX1/NADPH oxidase affects the development of autism-like behaviors in a maternal immune activation model

2021 ◽  
Vol 534 ◽  
pp. 59-66
Author(s):  
Xueqing Zhang ◽  
Masakazu Ibi ◽  
Ryu Haga ◽  
Kazumi Iwata ◽  
Misaki Matsumoto ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Immune Activation ◽  
Activation Model ◽  
Maternal Immune Activation

scholarly journals Ketogenic diet improves behaviors in a maternal immune activation model of autism spectrum disorder

PLoS ONE ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. e0171643 ◽  
Author(s):  
David N. Ruskin ◽  
Michelle I. Murphy ◽  
Sierra L. Slade ◽  
Susan A. Masino
Keyword(s):  
Autism Spectrum Disorder ◽  
Ketogenic Diet ◽  
Immune Activation ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Activation Model ◽  
Maternal Immune Activation
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