scholarly journals The role of the estrogen receptor-α gene, Esr1, in maternal-like behavior in juvenile female and male rats

2020 ◽  
Vol 216 ◽  
pp. 112797 ◽  
Author(s):  
Caileen R. Moran ◽  
Jill M. Gallagher ◽  
Robert S. Bridges
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Α ◽  
Male Rats ◽  
Juvenile Female ◽  
Estrogen Receptor Α Gene

Membrane estrogen receptor α is essential for estrogen signaling in the male skeleton

2018 ◽  
Vol 239 (3) ◽  
pp. 303-312 ◽  
Author(s):  
H H Farman ◽  
K L Gustafsson ◽  
P Henning ◽  
L Grahnemo ◽  
V Lionikaite ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Α ◽  
Estrogen Signaling ◽  
Areal Bone Mineral Density ◽  
Male Mice ◽  
Mineral Density ◽  
Intact Male ◽  
Trabecular Thickness ◽  
Total Body

The importance of estrogen receptor α (ERα) for the regulation of bone mass in males is well established. ERα mediates estrogenic effects both via nuclear and membrane-initiated ERα (mERα) signaling. The role of mERα signaling for the effects of estrogen on bone in male mice is unknown. To investigate the role of mERα signaling, we have used mice (Nuclear-Only-ER; NOER) with a point mutation (C451A), which results in inhibited trafficking of ERα to the plasma membrane. Gonadal-intact male NOER mice had a significantly decreased total body areal bone mineral density (aBMD) compared to WT littermates at 3, 6 and 9 months of age as measured by dual-energy X-ray absorptiometry (DEXA). High-resolution microcomputed tomography (µCT) analysis of tibia in 3-month-old males demonstrated a decrease in cortical and trabecular thickness in NOER mice compared to WT littermates. As expected, estradiol (E2) treatment of orchidectomized (ORX) WT mice increased total body aBMD, trabecular BV/TV and cortical thickness in tibia compared to placebo treatment. E2 treatment increased these skeletal parameters also in ORX NOER mice. However, the estrogenic responses were significantly decreased in ORX NOER mice compared with ORX WT mice. In conclusion, mERα is essential for normal estrogen signaling in both trabecular and cortical bone in male mice. Increased knowledge of estrogen signaling mechanisms in the regulation of the male skeleton may aid in the development of new treatment options for male osteoporosis.

Estrogen Receptor α Gene Polymorphisms and Bone Mineral Density in Healthy Children and Young Adults

2004 ◽  
Vol 74 (6) ◽  
pp. 495-500 ◽  
Author(s):  
A. M. Boot ◽  
I. M. van der Sluis ◽  
S. M. P. F. de Muinck Keizer-Schrama ◽  
J. B. J. van Meurs ◽  
E. P. Krenning ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Estrogen Receptor ◽  
Young Adults ◽  
Bone Mineral ◽  
Gene Polymorphisms ◽  
Estrogen Receptor Α ◽  
Healthy Children ◽  
Mineral Density ◽  
Children And Young Adults ◽  
Estrogen Receptor Α Gene

Association between estrogen receptor-α gene polymorphisms and dermatomyositis in Bulgarian patients

2014 ◽  
Vol 53 (7) ◽  
pp. e363-e364 ◽  
Author(s):  
Lyubomir Dourmishev ◽  
Zornitsa Kamenarska ◽  
Radka Kaneva ◽  
Vanio Mitev ◽  
Maria Hristova ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Gene Polymorphisms ◽  
Estrogen Receptor Α ◽  
Estrogen Receptor Α Gene

scholarly journals Preliminary genetic imaging study of the association between estrogen receptor-α gene polymorphisms and harsh human maternal parenting

2012 ◽  
Vol 525 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Benjamin B. Lahey ◽  
Kalina J. Michalska ◽  
Chunyu Liu ◽  
Qi Chen ◽  
Alison E. Hipwell ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Gene Polymorphisms ◽  
Imaging Study ◽  
Estrogen Receptor Α ◽  
Maternal Parenting ◽  
Estrogen Receptor Α Gene ◽  
Genetic Imaging

Association of the Estrogen Receptor-α Gene Polymorphism with the Risk of Endometriosis in Korean Women

2003 ◽  
Vol 26 (2) ◽  
pp. 91
Author(s):  
Sa Ra Lee ◽  
Sung Eun Hur ◽  
Hye Sung Moon ◽  
Hyung-Lae Kim ◽  
Hye Won Chung
Keyword(s):  
Estrogen Receptor ◽  
Gene Polymorphism ◽  
Estrogen Receptor Α ◽  
Korean Women ◽  
Estrogen Receptor Α Gene

scholarly journals Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α

2020 ◽  
Author(s):  
Shivani N. Mann ◽  
Niran Hadad ◽  
Molly Nelson-Holte ◽  
Alicia R. Rothman ◽  
Roshini Sathiaseelan ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Chronic Diseases ◽  
Transcriptional Activation ◽  
Estrogen Receptor Α ◽  
Metabolic Parameters ◽  
Metabolic Effects ◽  
Male Rats ◽  
Male Mice ◽  
Dietary Interventions ◽  
Estradiol Treatment

ABSTRACTMetabolic dysfunction underlies several chronic diseases, many of which are exacerbated by obesity. Dietary interventions can reverse metabolic declines and slow aging, although compliance issues remain paramount. 17α-estradiol treatment improves metabolic parameters and slows aging in male mice. The mechanisms by which 17α-estradiol elicits these benefits remain unresolved. Herein, we show that 17α-estradiol elicits similar genomic binding and transcriptional activation through estrogen receptor α (ERα) to that of 17β-estradiol. In addition, we show that the ablation of ERα completely attenuates the beneficial metabolic effects of 17α-E2 in male mice. Our findings suggest that 17α-E2 acts primarily through the liver and hypothalamus to improve metabolic parameters in male mice. Lastly, we also determined that 17α-E2 improves metabolic parameters in male rats, thereby proving that the beneficial effects of 17α-E2 are not limited to mice. Collectively, these studies suggest ERα may be a drug target for mitigating chronic diseases in male mammals.

scholarly journals Expression of Estrogen Receptor Alpha and Evaluation of Histological Degeneration Scores in Fibroblasts of Hypertrophied Ligamentum Flavum: A Qualitative Study

Biomolecules ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1752
Author(s):  
Christina C. Westhoff ◽  
Christian-Dominik Peterlein ◽  
Hanna Daniel ◽  
Juergen R. Paletta ◽  
Roland Moll ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Alpha ◽  
Ligamentum Flavum ◽  
Estrogen Receptor Α ◽  
Group Differences ◽  
Elastic Fibers ◽  
Disk Herniation ◽  
Spinal Decompression ◽  
Lumbar Spinal

The most common spinal disorder in elderly is lumbar spinal stenosis (LSS), resulting partly from ligamentum flavum (LF) hypertrophy. Its pathophysiology is not completely understood. The present study wants to elucidate the role of estrogen receptor α (ER α) in fibroblasts of hypertrophied LF. LF samples of 38 patients with LSS were obtained during spinal decompression. Twelve LF samples from patients with disk herniation served as controls. Hematoxylin & Eosin (H&E) and Elastica stains and immunohistochemistry for ER α were performed. The proportions of fibrosis, loss and/or degeneration of elastic fibers and proliferation of collagen fibers were assessed according to the scores of Sairyo and Okuda. Group differences in the ER α and Sairyo and Okuda scores between patients and controls, male and female sex and absence and presence of additional orthopedic diagnoses were assessed with the Mann–Whitney U test. There was a tendency towards higher expression of ER α in LF fibroblasts in the hypertrophy group (p = 0.065). The Sairyo and Okuda scores were more severe for the hypertrophy group but, in general, not statistically relevant. There was no statistically relevant correlation between the expression of ER α and sex (p = 0.326). ER α expression was higher in patients with osteochondrosis but not statistically significant (p = 0.113). In patients with scoliosis, ER α expression was significantly lower (p = 0.044). LF hypertrophy may be accompanied by a higher expression of ER α in fibroblasts. No difference in ER α expression was observed regarding sex. Further studies are needed to clarify the biological and clinical significance of these findings.

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