Role of spinal glial cells in excitability of wide dynamic range neurons and the development of neuropathic pain with the L5 spinal nerve transection in the rats: Behavioral and electrophysiological study

2019 ◽  
Vol 209 ◽  
pp. 112597 ◽  
Author(s):  
Laleh Rezaee ◽  
Homa Manaheji ◽  
Abbas Haghparast
Keyword(s):  
Neuropathic Pain ◽  
Glial Cells ◽  
Dynamic Range ◽  
Electrophysiological Study ◽  
Spinal Nerve ◽  
Nerve Transection ◽  
Wide Dynamic Range ◽  
Wide Dynamic Range Neurons

scholarly journals Intrathecal carbenoxolone inhibits neuropathic pain and spinal wide-dynamic range neuronal activity in rats after an L5 spinal nerve injury

2014 ◽  
Vol 563 ◽  
pp. 45-50 ◽  
Author(s):  
Qian Xu ◽  
Yong-Kwan Cheong ◽  
Fei Yang ◽  
Vinod Tiwari ◽  
Jinheng Li ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Nerve Injury ◽  
Neuronal Activity ◽  
Dynamic Range ◽  
Spinal Nerve ◽  
Wide Dynamic Range

scholarly journals IKBKB siRNA-Encapsulated Poly (Lactic-co-Glycolic Acid) Nanoparticles Diminish Neuropathic Pain by Inhibiting Microglial Activation

2021 ◽  
Vol 22 (11) ◽  
pp. 5657
Author(s):  
Seounghun Lee ◽  
Hyo-Jung Shin ◽  
Chan Noh ◽  
Song-I Kim ◽  
Young-Kwon Ko ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Microglial Activation ◽  
Glycolic Acid ◽  
Nuclear Factor Kappa B ◽  
Decisive Role ◽  
Plga Nanoparticles ◽  
Spinal Nerve ◽  
Nuclear Factor ◽  
Interfering Rna

Activation of nuclear factor-kappa B (NF-κB) in microglia plays a decisive role in the progress of neuropathic pain, and the inhibitor of kappa B (IκB) is a protein that blocks the activation of NF-κB and is degraded by the inhibitor of NF-κB kinase subunit beta (IKBKB). The role of IKBKB is to break down IκB, which blocks the activity of NF-kB. Therefore, it prevents the activity of NK-kB. This study investigated whether neuropathic pain can be reduced in spinal nerve ligation (SNL) rats by reducing the activity of microglia by delivering IKBKB small interfering RNA (siRNA)-encapsulated poly (lactic-co-glycolic acid) (PLGA) nanoparticles. PLGA nanoparticles, as a carrier for the delivery of IKBKB genes silencer, were used because they have shown potential to enhance microglial targeting. SNL rats were injected with IKBKB siRNA-encapsulated PLGA nanoparticles intrathecally for behavioral tests on pain response. IKBKB siRNA was delivered for suppressing the expression of IKBKB. In rats injected with IKBKB siRNA-encapsulated PLGA nanoparticles, allodynia caused by mechanical stimulation was reduced, and the secretion of pro-inflammatory mediators due to NF-κB was reduced. Delivering IKBKB siRNA through PLGA nanoparticles can effectively control the inflammatory response and is worth studying as a treatment for neuropathic pain.

scholarly journals Spinal integration of hot and cold nociceptive stimuli by wide-dynamic-range neurons in anesthetized adult rats

PAIN Reports ◽  
2021 ◽  
Vol 6 (4) ◽  
pp. e983
Author(s):  
Clémence Gieré ◽  
Meggane Melchior ◽  
André Dufour ◽  
Pierrick Poisbeau
Keyword(s):  
Dynamic Range ◽  
Wide Dynamic Range ◽  
Adult Rats ◽  
Wide Dynamic Range Neurons

scholarly journals A Comparison of RNA-Seq and Exon Arrays for Whole Genome Transcription Profiling of the L5 Spinal Nerve Transection Model of Neuropathic Pain in the Rat

2014 ◽  
Vol 10 ◽  
pp. 1744-8069-10-7 ◽  
Author(s):  
James R Perkins ◽  
Ana Antunes-Martins ◽  
Margarita Calvo ◽  
John Grist ◽  
Werner Rust ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Spinal Nerve ◽  
Whole Genome ◽  
Nerve Transection ◽  
Rna Seq ◽  
Transcription Profiling ◽  
Exon Arrays ◽  
Genome Transcription
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