Effect of dietary vitamin E on oxidative stress-related gene-mediated differences in anxiety-like behavior in inbred strains of mice

2019 ◽  
Vol 207 ◽  
pp. 64-72
Author(s):  
Keigo Matsuo ◽  
Tasuku Watanabe ◽  
Asako Takenaka
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Inbred Strains ◽  
Dietary Vitamin ◽  
Related Gene ◽  
Inbred Strains Of Mice ◽  
Oxidative Stress Related Gene

scholarly journals Effects of glutamine supplementation on oxidative stress-related gene expression and antioxidant properties in rats with streptozotocin-induced type 2 diabetes

2011 ◽  
Vol 107 (8) ◽  
pp. 1112-1118 ◽  
Author(s):  
Pei-Hsuan Tsai ◽  
Jun-Jen Liu ◽  
Chui-Li Yeh ◽  
Wan-Chun Chiu ◽  
Sung-Ling Yeh
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Amino Acid ◽  
Oxidative Damage ◽  
Antioxidant Capacity ◽  
Enzyme Activities ◽  
Antioxidant Enzyme Activities ◽  
Related Gene ◽  
Gene Expressions ◽  
Oxidative Stress Related Gene

There are close links among hyperglycaemia, oxidative stress and diabetic complications. Glutamine (GLN) is an amino acid with immunomodulatory properties. The present study investigated the effect of dietary GLN on oxidative stress-relative gene expressions and tissue oxidative damage in diabetes. There were one normal control (NC) and two diabetic groups in the present study. Diabetes was induced by an intraperitoneal injection of nicotinamide followed by streptozotocin (STZ). Rats in the NC group were fed a regular chow diet. In the two diabetic groups, one group (diabetes mellitus, DM) was fed a common semi-purified diet while the other group received a diet in which part of the casein was replaced by GLN (DM-GLN). GLN provided 25 % of total amino acid N. The experimental groups were fed the respective diets for 8 weeks, and then the rats were killed for further analysis. The results showed that blood thioredoxin-interacting protein (Txnip) mRNA expression in the diabetic groups was higher than that in the NC group. Compared with the DM group, the DM-GLN group had lower glutamine fructose-6-phosphate transaminase 1, a receptor of advanced glycation end products, and Txnip gene expressions in blood mononuclear cells. The total antioxidant capacity was lower and antioxidant enzyme activities were altered by the diabetic condition. GLN supplementation increased antioxidant capacity and normalised antioxidant enzyme activities. Also, the renal nitrotyrosine level and Txnip mRNA expression were lower when GLN was administered. These results suggest that dietary GLN supplementation decreases oxidative stress-related gene expression, increases the antioxidant potential and may consequently attenuate renal oxidative damage in rats with STZ-induced diabetes.

Oxidative stress-related gene interactions with preterm delivery in Korean women

2008 ◽  
Vol 198 (5) ◽  
pp. 541.e1-541.e7 ◽  
Author(s):  
Young Ju Suh ◽  
Young Ju Kim ◽  
Hyesook Park ◽  
Eun Ae Park ◽  
Eun Hee Ha
Keyword(s):  
Oxidative Stress ◽  
Preterm Delivery ◽  
Gene Interactions ◽  
Korean Women ◽  
Related Gene ◽  
Oxidative Stress Related Gene

scholarly journals Novel recombinant human lactoferrin: Differential activation of oxidative stress related gene expression

2013 ◽  
Vol 168 (4) ◽  
pp. 666-675 ◽  
Author(s):  
Marian L. Kruzel ◽  
Jeffrey K. Actor ◽  
Michał Zimecki ◽  
Jasen Wise ◽  
Paulina Płoszaj ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Human Lactoferrin ◽  
Related Gene ◽  
Differential Activation ◽  
Recombinant Human Lactoferrin ◽  
Oxidative Stress Related Gene

Oxidative stress in colon tissue induced by vitamin E depletion

2004 ◽  
Vol 32 (6) ◽  
pp. 979-981 ◽  
Author(s):  
J.E. Drew ◽  
D.K. Mercer ◽  
C. Mayer ◽  
A.J. Farquharson ◽  
P.C. Morrice ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Morphological Changes ◽  
Membrane Integrity ◽  
Dietary Vitamin ◽  
Colon Tissue ◽  
Cell Membrane Integrity ◽  
Markers Of Oxidative Stress ◽  
Lipid Soluble Antioxidant ◽  
Dietary Deficiency

Inflammatory disorders of the bowel and colon cancer are associated with elevated indices of oxidative stress. Analogous elevations in markers of oxidative stress and loss of cell-membrane integrity are also observed in the colons of rats deficient in vitamin E (D-α-tocopherol), the major lipid-soluble antioxidant in biological systems. The causal relationship between colon pathologies associated with oxidative stress and dietary deficiency in antioxidant vitamins such as vitamin E is still uncertain. Investigation of potential mechanisms by which lack of dietary vitamin E may lead to clinically relevant pathological changes in colon tissue was conducted using gene expression profiling strategies on vitamin E-sufficient and -deficient rats. Morphological changes and increased indices of lipid peroxidation were linked to vitamin E deficiency. These changes in colon tissue are potentially important in disease pathogenesis of the colon linked with oxidative stress or other direct consequences of inadequate levels of vitamin E.

A positive correlation between mercury and oxidative stress-related gene expression (GPX3 and GSTM3) is measured in female Double-crested Cormorant blood

Ecotoxicology ◽  
2014 ◽  
Vol 23 (6) ◽  
pp. 1004-1014 ◽  
Author(s):  
Laura A. Gibson ◽  
Raphael A. Lavoie ◽  
Sonja Bissegger ◽  
Linda M. Campbell ◽  
Valerie S. Langlois
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Related Gene ◽  
Positive Correlation ◽  
Oxidative Stress Related Gene ◽  
And Oxidative Stress

scholarly journals The Effect of Dietary Iron Level on Lipid Peroxidation of Muscle Food

1995 ◽  
Author(s):  
Joseph Kanner ◽  
Dennis Miller ◽  
Ido Bartov ◽  
John Kinsella ◽  
Stella Harel
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Vitamin E ◽  
Glutathione Peroxidase ◽  
Dietary Vitamin ◽  
Dietary Iron ◽  
Blood Hemoglobin ◽  
Muscle Tissues ◽  
Iron Pool

Biological oxidations are almost exclusively metal ion-promoted reactions and in ths respect iron, being the most abundant, is the commonly involved. The effect of dietary iron levels on pork, turkey and chick muscle lipid peroxidation and various other related compounds were evaluated. Crossbred feeder pigs were fed to market weight on corn-soy rations containing either 62, 131 or 209 ppm iron. After slaughter, the muscles were dissected, cooked and stored at 4°C. Heavily fortifying swine rations with iron (>200 ppm) increase nn-heme iron (NHI), thiobarbituric acid reactive substances (TBARS), and decrease a-tocopherol in cooked stored pork but did not increase warmed-over aroma (WOA). NHI and TBARS were higher in cooked pork from pigs fed high-iron diets. Liver iron correlated with muscle iron. TBARS were strongly related with WOA. The role of dietary vitamin E and ascorbic acid on Fe-induced in vivo lipid peroxidation in swine was also evaluated. Moderate elevation in iron stores had a marked effect on oxidative stress, especially as indicated by liver TBARS. Supplemental vitamin E, and to a lesser extent vitamin C, protect against this oxidative stress. Unsupplementation of Fe in the regular diet of turkeys did not affect body weight, blood hemoglobin level, or iron pool in the liver or muscle. The reason being that it contained "natural" ~120 mg Fe/kg feed, and this amount is high enough to keep constant the pool of iron in the body, liver or muscle tissues. Only Fe-supplementation with high amounts of Fe (500 ppm) significantly increased turkey blood hemoglobin and total iron in the liver, in 1 out of 3 experiments, but only slightly affects iron pool in the muscles. It seems that the liver accumulates very high concentations of iron and significantly regulates iron concentration in skeletal muscles. For this reason, it was very difficult to decrease muscle stability in turkeys through a diet containing high levels of Fe-supplementation. It was shown that the significant increase in the amount of iron (total and "free") in the muscle by injections with Fe-dextran accelerated its lipid peroxidation rate and decreased its a-tocopherol concentration. The level and metabolism of iron in the muscles affects the intensity of in vivo lipid peroxidation. This process was found to ifluence the turnover and accumulation of a-tocopherol in turkey and chick muscles. Treatments which could significantly decrease the amount and metabolism of iron pool in muscle tissues (or other organs) may affect the rate of lipid peroxidation and the turnover of a-tocopherol. Several defense enzymes were determined and found in the turkey muscle, such as superoxide dismutase, catalase, and glutathione peroxidase. Glutathione peroxidase was more active in muscles with a high trend of lipid peroxidation, lmore so in drumsticks than in breast muscles, or muscles with a low a-tocopherol content. The activity of glutathione peroxidase increased several fold in muscle stored at 4°C. Our work demonstrated that it will be much more practical to increase the stability of muscle tissues in swine, turkeys and chickens during storage and processing by increasing the amount of vitamin E in the diet than by withdrawing iron supplementation.

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