Voluntary wheel running effects on intra-accumbens opioid high-fat feeding and locomotor behavior in Sprague-Dawley and Wistar rat strains

2019 ◽  
Vol 206 ◽  
pp. 67-75 ◽  
Author(s):  
Jenna R. Lee ◽  
Kyle E. Parker ◽  
Melissa Tapia ◽  
Howard W. Johns ◽  
Ted G. Floros ◽  
...  
Keyword(s):  
Wheel Running ◽  
Wistar Rat ◽  
Locomotor Behavior ◽  
Sprague Dawley ◽  
High Fat ◽  
Rat Strains ◽  
Voluntary Wheel Running ◽  
Fat Feeding ◽  
Voluntary Wheel

Comparison of anorexia, lethargy, and fever induced by bacterial and viral mimetics in rats

2009 ◽  
Vol 87 (3) ◽  
pp. 211-220 ◽  
Author(s):  
Nicola Hopwood ◽  
Tlangelani Maswanganyi ◽  
Lois M. Harden
Keyword(s):  
Wheel Running ◽  
Poly I:C ◽  
Sprague Dawley ◽  
Voluntary Wheel Running ◽  
Polycytidylic Acid ◽  
Cage Activity ◽  
Sprague Dawley Rats ◽  
Sickness Behaviors ◽  
Saline Administration ◽  
Voluntary Wheel

Although it has been established that some acute phase responses present differently depending on whether a virus or bacteria activates the innate immune system, it has not yet been established whether fever and sickness behaviors, such as anorexia and lethargy, present differently. We therefore investigated the effects of administering lipopolysaccharide (LPS) and polyinosinic : polycytidylic acid (poly I:C) on body temperature, food intake, body mass, and activity (cage activity and wheel running). Male Sprague–Dawley rats were randomly assigned to receive an intraperitoneal injection of one of LPS (75 µg/kg or 250 µg/kg), poly I:C (3000 µg/kg or 4000 µg/kg), or saline. Administration of LPS or poly I:C induced fever, anorexia, and lethargy. Although voluntary wheel running and cage activity were both significantly reduced after administration of LPS or poly I:C, they were not affected equally. Indeed voluntary wheel running was decreased on average by approximately 30% more than cage activity regardless of the dose or type of mimetic administered. Our results indicate that poly I:C is less effective at inducing anorexia, lethargy, and fever in rats than is LPS, and that avoidance of exercise in animals and humans during infection is likely to be a more prominent feature of illness than is avoidance of routine daily activity.

Effects of a high-fat diet and voluntary wheel running on gluconeogenesis and lipolysis in rats

1999 ◽  
Vol 86 (4) ◽  
pp. 1374-1380 ◽  
Author(s):  
Deborah A. Podolin ◽  
Yuren Wei ◽  
Michael J. Pagliassotti
Keyword(s):  
High Fat Diet ◽  
Corn Oil ◽  
Wheel Running ◽  
Whole Body ◽  
Free Access ◽  
Fat Pad ◽  
High Fat ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel

The purpose of the present study was to determine the effects of diet composition and exercise on glycerol and glucose appearance rate (Ra) and on nonglycerol gluconeogenesis (Gneo) in vivo. Male Wistar rats were fed a high-starch diet (St, 68% of energy as cornstarch, 12% corn oil) for a 2-wk baseline period and then were randomly assigned to one of four experimental groups: St ( n = 7), high-fat (HF; 35% cornstarch, 45% corn oil; n = 8), St with free access to exercise wheels (StEx; n = 7), and HF with free access to exercise wheels (HFEx; n = 7). After 8 wk, glucose Rawhen using [3-3H]glucose, glycerol Rawhen using [2H5]glycerol (estimate of whole body lipolysis), and [3-13C]alanine incorporation into glucose (estimate of alanine Gneo) were determined. Body weight and fat pad mass were significantly ( P < 0.05) decreased in exercise vs. sedentary animals only. The average amount of exercise was not significantly different between StEx (3,212 ± 659 m/day) and HFEx (3,581 ± 765 m/day). The ratio of glucose to alanine enrichment and absolute glycerol Ra(μmol/min) were higher ( P < 0.05) in HF and HFEx compared with St and StEx rats. In separate experiments, the ratio of3H in C-2 to C-6 of glucose from3H2O (estimate of Gneo from pyruvate) was also higher ( P < 0.05) in HF ( n = 5) and HFEx ( n = 5), compared with St ( n = 5) and StEx ( n = 5) rats. Voluntary wheel running did not significantly increase estimated alanine or pyruvate Gneo or absolute glycerol Ra. Voluntary wheel running increased ( P< 0.05) glycerol Rawhen normalized to fat pad mass. These data suggest that a high-fat diet can increase in vivo Gneo from precursors that pass through pyruvate. They also suggest that changes in the absolute rate of glycerol Ramay contribute to the high-fat diet-induced increase in Gneo.

scholarly journals Effects of a High Fat Diet and Voluntary Wheel Running Exercise on Cidea and Cidec Expression in Liver and Adipose Tissue of Mice

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0130259 ◽  
Author(s):  
Thomas H. Reynolds ◽  
Sayani Banerjee ◽  
Vishva Mitra Sharma ◽  
Jacob Donohue ◽  
Sandrine Couldwell ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
High Fat Diet ◽  
Wheel Running ◽  
High Fat ◽  
Voluntary Wheel Running ◽  
Running Exercise ◽  
Voluntary Wheel

scholarly journals PO-034 Effect of Voluntary Exercise on Cartilage Morphology of Knee Osteoarthritis in Obese Mice Induced by High-fat Diet

2018 ◽  
Vol 1 (3) ◽  
Author(s):  
Wenhao Zong ◽  
Yang Liu ◽  
Lulu Dai ◽  
Guijun Dong
Keyword(s):  
Articular Cartilage ◽  
Knee Osteoarthritis ◽  
High Fat Diet ◽  
Wheel Running ◽  
Cartilage Thickness ◽  
Obese Mice ◽  
High Fat ◽  
Voluntary Wheel Running ◽  
Running Exercise ◽  
Voluntary Wheel

Objective To examine the effect of voluntary wheel-running exercise on cartilage morphology of knee osteoarthritis(KOA) in obese mice induced by high-fat diet,and explore the protective role of 4 weeks voluntary wheel-running exercise on KOA,finally providing effective experimental evidence for clinical treatment of knee osteoarthritis. Methods C57BL/6J mice were randomly assigned to the C-Sed group,C-Ex group,HF-Sed group and HF-Ex group.The control groups were fed a control diet(13.5% kcal from fat),and the high-fat groups were fed a high-fat diet(60% kcal from fat).After feeding 8 weeks different diets,the exercise groups were starting running.In order to examine the effect of voluntary wheel-running exercise on cartilage morphology of KOA,the joint of knee were harvested to be fixed,decalcified and embedded in paraffin,and the four-micrometer-thick sections were stained with both HE and toluidine blue . Results After feeding twelve weeks different diets,the body mass of the high-fat diet group mice has a significant increase,which demonstrates that high-fat diet could successfully induce the mice obese.From the results of HE and toluidine blue,in comparison to the C-Sed group,the surface of the knee articular cartilage in the HF-Sed group was not intact and smooth,and the thickness of articular cartilage has a significant decrease（p<0.001）;contrary to the HF-Sed group,the surface of the knee articular cartilage in HF-Ex group was slightly smooth,and there was significant increase in cartilage thickness. Conclusions Four weeks voluntary wheel-running exercise can increase cartilage thickness ,decrease the Mankin’s score and delay the degeneration of knee cartilage in obese mice.To conclude,the short-term wheel-running exercise protects against obesity-induced KOA.

scholarly journals Effect of Voluntary Wheel Running on Striatal Dopamine Level and Neurocognitive Behaviors after Molar Loss in Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Linlin Zhang ◽  
Yi Feng ◽  
Wenliang Ji ◽  
Jianzhang Liu ◽  
Kun Liu
Keyword(s):  
Physical Exercise ◽  
Wheel Running ◽  
Striatal Dopamine ◽  
Control Group ◽  
Dopamine Level ◽  
Sprague Dawley ◽  
Voluntary Wheel Running ◽  
Cognition And Emotion ◽  
Voluntary Wheel

The aim of the present study is to evaluate the effect of voluntary wheel running on striatal dopamine level and behavior of cognition and emotion in molar loss rats. Twenty-four Sprague-Dawley rats were enrolled in this study and randomly divided into following 4 groups: control group (C group), molar loss group (ML group), 1-week physical exercise before molar loss group (1W-ML group), and 4-week physical exercise before molar loss group (4W-ML group). The rats both in 4W-ML and 1W-ML groups were placed in the voluntary running wheel in order to exercise for 4 weeks and 1 week, respectively. Then, the rats in 4W-ML, 1W-M, and ML groups received bilateral molar loss operation. After 10 days, striatal dopamine level was detected by in vivo microdialysis coupled with high-performance liquid chromatography (HPLC) and electrochemical detection. All the rats received behavior test after microdialysis detection. The behavior tests including passive avoidance test were used to assess cognition and elevated plus maze test for emotion. The results indicated that voluntary wheel running promoted striatal dopamine level in rats of molar loss. Behavioral data indicated that voluntary wheel running promoted cognition and emotion recovery after molar loss. Therefore, we concluded physical exercise significantly improved the neurocognitive behaviors and increased the striatal dopamine level after molar loss in rats.

scholarly journals High Fat High Sugar Diet Reduces Voluntary Wheel Running in Mice Independent of Sex Hormone Involvement

2017 ◽  
Vol 8 ◽  
Author(s):  
Heather L. Vellers ◽  
Ayland C. Letsinger ◽  
Nicholas R. Walker ◽  
Jorge Z. Granados ◽  
J. Timothy Lightfoot
Keyword(s):  
Wheel Running ◽  
Sex Hormone ◽  
High Fat ◽  
Voluntary Wheel Running ◽  
High Sugar ◽  
Voluntary Wheel

Introduction Of A High-fat/sucrose Diet Modulates Voluntary Wheel Running Activity In Adult Female Rats

2017 ◽  
Vol 49 (5S) ◽  
pp. 440
Author(s):  
Jon-Philippe K. Hyatt ◽  
Lindsay Caprio ◽  
Elisa J. Bienenstock ◽  
Jung A. Kim ◽  
Gary E. McCall
Keyword(s):  
Adult Female ◽  
Wheel Running ◽  
Female Rats ◽  
High Fat ◽  
Voluntary Wheel Running ◽  
Running Activity ◽  
Wheel Running Activity ◽  
Sucrose Diet ◽  
Voluntary Wheel
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