scholarly journals Awake, long-term intranasal insulin treatment does not affect object memory, odor discrimination, or reversal learning in mice

2017 ◽  
Vol 174 ◽  
pp. 104-113 ◽  
Author(s):  
Genevieve A. Bell ◽  
Debra Ann Fadool
Keyword(s):  
Reversal Learning ◽  
Insulin Treatment ◽  
Odor Discrimination ◽  
Intranasal Insulin ◽  
Object Memory

The Effect of Long-Term Metabolic Control on Free Thyroid Hormone Levels in Diabetics during Insulin Treatment

1987 ◽  
Vol 24 (5) ◽  
pp. 466-469 ◽  
Author(s):  
J H Parr
Keyword(s):  
Thyroid Hormone ◽  
Metabolic Control ◽  
Insulin Treatment ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Hormone Levels ◽  
Free Thyroid Hormone ◽  
The Mean ◽  
Thyroid Hormone Levels

Serum concentration of free T3 and, in female patients, FT4, were found to be lower in 20 asymptomatic, moderately-poor or well controlled, diabetics treated with insulin than in a group of non-diabetic subjects. Over a mean 3-month period of the study a significant fall occurred in HbA1 concentration in both groups of diabetics without change in free thyroid hormone levels. The mean capillary blood glucose, fasting free insulin and fasting lipid concentrations, other than high density lipoprotein (HDL) cholesterol, did not change. No correlations were found between the changes in HbA1 and free thyroid hormone concentrations. Improvement in long term metabolic control did not influence free thyroid hormone levels in well controlled and moderately-poor controlled diabetics, taking insulin.

scholarly journals Hyperinsulinemia adversely affects lung structure and function

2016 ◽  
Vol 310 (9) ◽  
pp. L837-L845 ◽  
Author(s):  
Suchita Singh ◽  
Manish Bodas ◽  
Naveen K. Bhatraju ◽  
Bijay Pattnaik ◽  
Atish Gheware ◽  
...  
Keyword(s):  
Insulin Treatment ◽  
Epithelial Mesenchymal Transition ◽  
Respiratory Health ◽  
Structure And Function ◽  
Intranasal Insulin ◽  
Mesenchymal Transition ◽  
Inhaled Insulin ◽  
Lung Structure ◽  
Prevalence Of Obesity ◽  
And Function

There is limited knowledge regarding the consequences of hyperinsulinemia on the lung. Given the increasing prevalence of obesity, insulin resistance, and epidemiological associations with asthma, this is a critical lacuna, more so with inhaled insulin on the horizon. Here, we demonstrate that insulin can adversely affect respiratory health. Insulin treatment (1 μg/ml) significantly ( P < 0.05) increased the proliferation of primary human airway smooth muscle (ASM) cells and induced collagen release. Additionally, ASM cells showed a significant increase in calcium response and mitochondrial respiration upon insulin exposure. Mice administered intranasal insulin showed increased collagen deposition in the lungs as well as a significant increase in airway hyperresponsiveness. PI3K/Akt mediated activation of β-catenin, a positive regulator of epithelial-mesenchymal transition and fibrosis, was observed in the lungs of insulin-treated mice and lung cells. Our data suggests that hyperinsulinemia may have adverse effects on airway structure and function. Insulin-induced activation of β-catenin in lung tissue and the contractile effects on ASM cells may be causally related to the development of asthma-like phenotype.

Effect of insulin treatment on smooth muscle calmodulin levels in rats with long-term streptozotocin-diabetes

1996 ◽  
Vol 116 (1) ◽  
pp. 67-71 ◽  
Author(s):  
Süleyman Aydin ◽  
Yusuf Öztürk ◽  
V.Melih Altan ◽  
Nuray Yildizoğlu-Ari ◽  
A.Tanju Özçelikay
Keyword(s):  
Smooth Muscle ◽  
Insulin Treatment ◽  
Streptozotocin Diabetes

719-P: Caloric Intake, Appetite, and Body Composition Outcomes of Long-Term Intranasal Insulin (INI) Administration: A Substudy of the Memory Advancement by INI in Type 2 Diabetes (MemAID) Study

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 719-P
Author(s):  
LAURA APONTE BECERRA ◽  
FAIZAN KHAN ◽  
LONG H. NGO ◽  
VERA NOVAK ◽  
CHRISTOS MANTZOROS
Keyword(s):  
Type 2 Diabetes ◽  
Body Composition ◽  
Caloric Intake ◽  
Intranasal Insulin

scholarly journals Predictors of Long-Term Glycemic Remission After 2-Week Intensive Insulin Treatment in Newly Diagnosed Type 2 Diabetes

2019 ◽  
Vol 104 (6) ◽  
pp. 2153-2162 ◽  
Author(s):  
Hui Wang ◽  
Jian Kuang ◽  
Mingtong Xu ◽  
Zhengnan Gao ◽  
Qifu Li ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Treatment ◽  
Newly Diagnosed ◽  
Intensive Insulin Treatment

Long-term efficacy and safety of vildagliptin add-on therapy in type 2 diabetes mellitus with insulin treatment

2017 ◽  
Vol 123 ◽  
pp. 9-17 ◽  
Author(s):  
Ippei Kanazawa ◽  
Ken-ichiro Tanaka ◽  
Masakazu Notsu ◽  
Sayuri Tanaka ◽  
Nobuaki Kiyohara ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Treatment ◽  
Efficacy And Safety ◽  
Term Efficacy

Prehospital Treatment of Severe Hypoglycaemia: A Comparison of Intramuscular Glucagon and Intravenous Glucose

1998 ◽  
Vol 13 (2-4) ◽  
pp. 44-50 ◽  
Author(s):  
Søren Carstens ◽  
Michael Sprehn
Keyword(s):  
Recovery Time ◽  
Insulin Treatment ◽  
Severe Hypoglycaemia ◽  
Demographic Data ◽  
Intravenous Glucose ◽  
Prehospital Treatment ◽  
Patient Interviews ◽  
Patient Will ◽  
Intensified Insulin Treatment

AbstractIntroduction:By introducing an intensified insulin treatment regime to patients with insulin-dependant diabetes mellitus (IDDM), the frequency of long-term complications that the patient will experience has been shown to decrease. The price is an increase in the frequency of severe and mild hypoglycaemic events. Therefore, constant monitoring of these patients is necessary.Hypothesis:This study compares the time until full recovery of IDDM patients with severe hypoglycaemia after treatment with either intravenous glucose or intramuscular glucagon.Methods:14 patients with IDDM with severe hypoglycaemia requiring treatment by the medical staff was randomised to treatment either with 50 ml of 50% glucose intravenously or intramuscular 1 mg glucagon. The time to recovery was recorded. Plasma glucose was measured at fixed intervals to achieve a glycaemia profile. Demographic data were acquired through patient interviews following recovery.Results:Recovery time between the two groups was significantly different statistically. Recovery time ranged for 1 to 3 minutes for those receiving glucose intravenously and 8 to 21 minutes for those receiving intramuscular glucagon. Characteristic glycaemia profiles were identified and differences were present between the two groups with a greater fluctuating pattern for the glucose group compared to the steadily increasing pattern seen after glucagon treatment. Alcohol was believed to be involved in 8 out of the 14 cases, and thereby, is the major confounding factor in this study.Conclusion:Intramuscularly administered glucagon is a safe and reliable alternative to intravenous glucose infusion. The fluctuating glyceamia pattern seen after glucose treatment indicates a low risk for secondary hypoglycaemia. However, further studies are necessary to support this assertion.

Long‐term insulin treatment leads to a change in myosin heavy chain fiber distribution in OLETF rat skeletal muscle

2018 ◽  
Vol 120 (2) ◽  
pp. 2404-2412 ◽  
Author(s):  
Oak‐Kee Hong ◽  
Yoon‐Hee Choi ◽  
Hyuk‐Sang Kwon ◽  
Hee‐Kyoung Jeong ◽  
Jang‐Won Son ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Insulin Treatment ◽  
Fiber Distribution ◽  
Rat Skeletal Muscle ◽  
Oletf Rat
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