Caffeine stimulates voluntary wheel running in mice without increasing aerobic capacity

2017 ◽  
Vol 170 ◽  
pp. 133-140 ◽  
Author(s):  
Gerald C. Claghorn ◽  
Zoe Thompson ◽  
Kristianna Wi ◽  
Lindsay Van ◽  
Theodore Garland
Keyword(s):  
Aerobic Capacity ◽  
Wheel Running ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel

Effects Of Intrinsic Aerobic Capacity And Ovariectomy on Voluntary Wheel Running and Mid-brain Dopamine Signaling

2016 ◽  
Vol 48 ◽  
pp. 823
Author(s):  
Young-Min Park ◽  
Jill A. Kanaley ◽  
Jaume Padilla ◽  
Terese Zidon ◽  
Rebecca Welly ◽  
...  
Keyword(s):  
Aerobic Capacity ◽  
Wheel Running ◽  
Brain Dopamine ◽  
Voluntary Wheel Running ◽  
Dopamine Signaling ◽  
Voluntary Wheel

Artificial selection for high activity favors mighty mini-muscles in house mice

2003 ◽  
Vol 284 (2) ◽  
pp. R433-R443 ◽  
Author(s):  
Philippe Houle-Leroy ◽  
Helga Guderley ◽  
John G. Swallow ◽  
Theodore Garland
Keyword(s):  
Muscle Mass ◽  
Aerobic Capacity ◽  
Citrate Synthase ◽  
Wheel Running ◽  
Relative Mass ◽  
Selected Lines ◽  
Voluntary Wheel Running ◽  
Total Body Mass ◽  
Selection For ◽  
Voluntary Wheel

After 14 generations of selection for voluntary wheel running, mice from the four replicate selected lines ran, on average, twice as many revolutions per day as those from the four unselected control lines. To examine whether the selected lines followed distinct strategies in the correlated responses of the size and metabolic capacities of the hindlimb muscles, we examined mice from selected lines, housed for 8 wk in cages with access to running wheels that were either free to rotate (“wheel access” group) or locked (“sedentary”). Thirteen of twenty individuals in one selected line (line 6) and two of twenty in another (line 3) showed a marked reduction (∼50%) in total hindlimb muscle mass, consistent with the previously described expression of a small-muscle phenotype. Individuals with these “mini-muscles” were not significantly smaller in total body mass compared with line-mates with normal-sized muscles. Access to free wheels did not affect the relative mass of the mini-muscles, but did result in typical mammalian training effects for mitochondrial enzyme activities. Individuals with mini-muscles showed a higher mass-specific muscle aerobic capacity as revealed by the maximal in vitro rates of citrate synthase and cytochrome c oxidase. Moreover, these mice showed the highest activities of hexokinase and carnitine palmitoyl transferase. Females with mini-muscles showed the highest levels of phosphofructokinase, and males with mini-muscles the highest levels of pyruvate dehydrogenase. As shown by total muscle enzyme contents, the increase in mass-specific aerobic capacity almost completely compensated for the reduction caused by the “loss” of muscle mass. Moreover, the mini-muscle mice exhibited the lowest contents of lactate dehydrogenase and glycogen phosphorylase. Interestingly, metabolic capacities of mini-muscled mice resemble those of muscles after endurance training. Overall, our results demonstrate that during selection for voluntary wheel running, distinct adaptive paths that differentially exploit the genetic variation in morphological and physiological traits have been followed.

scholarly journals Treadmill Training Improves Aerobic Capacity in Aged Male Mice Compared to Voluntary Wheel Running

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 688-688
Author(s):  
Emily Schmitt ◽  
Hunter Graves ◽  
Danielle Bruns
Keyword(s):  
Aerobic Capacity ◽  
Wheel Running ◽  
Treadmill Training ◽  
Treadmill Running ◽  
Time To Exhaustion ◽  
Male Mice ◽  
Voluntary Wheel Running ◽  
Age Related ◽  
Training Protocol ◽  
Voluntary Wheel

Abstract Preclinical exercise studies typically use two forms of exercise training protocols: 1) voluntary wheel running and 2) forced treadmill running. Previous work from our group clearly demonstrates that older (18-month-old) male mice do not voluntarily engage in wheel running, especially compared to younger males or female mice. Therefore, we implemented a forced exercise treadmill training protocol to determine if treadmill training was superior to wheel running in improving aerobic capacity in older male mice. Purpose To determine if a 3-week treadmill training protocol improved time to exhaustion (TTE) in older male mice. Methods 18-month-old male mice (n=5) were provided a running wheel in their individual cage for 2 weeks or underwent daily treadmill training (n=6) for 3 weeks with increasing speed/incline. At the end of the training period we assessed TTE. Results Older male mice that trained on the treadmill demonstrated higher TTE compared to wheel (1382 □ 32 seconds versus 500 □ 99 seconds, respectively). In addition, older male mice that trained on the treadmill improved on average ~8% in their TTE test. Conclusion A 3-week treadmill training protocol improves aerobic capacity in older male mice to a greater extent than voluntary wheel running. Ongoing experiments will utilize this training protocol to understand age-related declines in cardiorespiratory fitness, circadian rhythm, and to test exercise as an intervention in the aging population.

scholarly journals Voluntary Wheel Running Selectively Augments Insulin-Stimulated Vasodilation in Arterioles from White Skeletal Muscle of Insulin-Resistant Rats

2012 ◽  
Vol 19 (8) ◽  
pp. 729-738 ◽  
Author(s):  
Catherine R. Mikus ◽  
Bruno T. Roseguini ◽  
Grace M. Uptergrove ◽  
E. Matthew Morris ◽  
Randy Scott Rector ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Wheel Running ◽  
Voluntary Wheel Running ◽  
Insulin Resistant ◽  
Voluntary Wheel

scholarly journals The Effect of Voluntary Wheel Running on Muscle Mass, Mitochondrial Function and Oxidative Damage in Sod1???/???mice

2006 ◽  
Vol 38 (Suppl 1) ◽  
pp. S12
Author(s):  
Michael S. Lustgarten ◽  
Young C. Jang ◽  
Wook Song ◽  
Yuhong Liu ◽  
Anson Pierce ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Muscle Mass ◽  
Mitochondrial Function ◽  
Wheel Running ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel

P.1.05 Involvement of DARPP-32, FosB, and dynorphin in voluntary wheel running

2008 ◽  
Vol 18 ◽  
pp. s5-s6 ◽  
Author(s):  
A. Borgkvist ◽  
E.J. Nestler ◽  
P. Greengard ◽  
G. Fisone ◽  
S. Brené
Keyword(s):  
Wheel Running ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel
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