Paired-housing selectively facilitates within-session extinction of avoidance behavior, and increases c-Fos expression in the medial prefrontal cortex, in anxiety vulnerable Wistar-Kyoto rats

2016 ◽  
Vol 164 ◽  
pp. 198-206 ◽  
Author(s):  
Ian M. Smith ◽  
Kevin C.H. Pang ◽  
Richard J. Servatius ◽  
Xilu Jiao ◽  
Kevin D. Beck
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Avoidance Behavior ◽  
Wistar Kyoto Rats ◽  
Fos Expression ◽  
Wistar Kyoto

The role of prefrontal cortex dopamine D2 and D3 receptors in the mechanism of action of venlafaxine and deep brain stimulation in animal models of treatment-responsive and treatment-resistant depression

2019 ◽  
Vol 33 (6) ◽  
pp. 748-756 ◽  
Author(s):  
Mariusz Papp ◽  
Piotr Gruca ◽  
Magdalena Lason ◽  
Monika Niemczyk ◽  
Paul Willner
Keyword(s):  
Prefrontal Cortex ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Memory Consolidation ◽  
Wistar Rats ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Wistar Kyoto Rats ◽  
Wistar Kyoto ◽  
Deep Brain

Aims: The Wistar-Kyoto rat has been validated as an animal model of treatment-resistant depression. Here we investigated a role of dopamine D2 and D3 receptors in the ventro-medial prefrontal cortex in the mechanism of action of deep brain stimulation in Wistar-Kyoto rats and venlafaxine in Wistar rats. Methods: Wistar or Wistar-Kyoto rats were exposed chronically to chronic mild stress. Wistar rats were treated chronically with venlafaxine (10 mg/kg) beginning after two weeks of chronic mild stress; Wistar-Kyoto rats received two sessions of deep brain stimulation before behavioural tests. L-742,626 (1 µg), a D2 receptor agonist, or 7-OH DPAT (3 µg), a D3 receptor antagonist, were infused into the ventro-medial prefrontal cortex immediately following the exposure trial in the Novel Object Recognition Test, and discrimination between novel and familiar object was tested one hour later. Results: Chronic mild stress decreased sucrose intake and impaired memory consolidation; these effects were reversed by venlafaxine in Wistar rats and deep brain stimulation in Wistar-Kyoto rats. In control animals, L-742,626 and 7-OH DPAT also impaired memory consolidation. In Wistar rats, venlafaxine reversed the effect of L-742,626 in controls, but not in the chronic mild stress group, and venlafaxine did not reverse the effect of 7-OH DPAT in either group. In Wistar-Kyoto rats, deep brain stimulation reversed the effect of both L-742,626 and 7-OH DPAT in both control and chronic mild stress groups. Conclusions: We conclude that the action of venlafaxine to reverse the impairment of memory consolidation caused by chronic mild stress in Wistar rats involves D2 receptors in the ventro-medial prefrontal cortex; but the effect of deep brain stimulation to reverse the same effect in Wistar-Kyoto rats does not.

Sensitized Fos expression in subterritories of the rat medial prefrontal cortex and nucleus accumbens following amphetamine sensitization as revealed by stereology

2002 ◽  
Vol 950 (1-2) ◽  
pp. 165-179 ◽  
Author(s):  
Gaël Hédou ◽  
Ana Lúcia Jongen-Rêlo ◽  
Carol A Murphy ◽  
Christian A Heidbreder ◽  
Joram Feldon
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Medial Prefrontal Cortex ◽  
Fos Expression ◽  
Amphetamine Sensitization

Fos expression following self-stimulation of the medial prefrontal cortex

2000 ◽  
Vol 107 (1-2) ◽  
pp. 123-132 ◽  
Author(s):  
Andreas Arvanitogiannis ◽  
Thomas M Tzschentke ◽  
Luigi Riscaldino ◽  
Roy A Wise ◽  
Peter Shizgal
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Fos Expression ◽  
Self Stimulation ◽  
Stimulation Of
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