scholarly journals Dietary nitrate modulates cerebral blood flow parameters and cognitive performance in humans: A double-blind, placebo-controlled, crossover investigation

2015 ◽  
Vol 149 ◽  
pp. 149-158 ◽  
Author(s):  
Emma L. Wightman ◽  
Crystal F. Haskell-Ramsay ◽  
Kevin G. Thompson ◽  
Jamie R. Blackwell ◽  
Paul G. Winyard ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Performance ◽  
Double Blind ◽  
Dietary Nitrate ◽  
Double Blind Placebo ◽  
Flow Parameters

scholarly journals Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation

2014 ◽  
Vol 112 (2) ◽  
pp. 203-213 ◽  
Author(s):  
Emma L. Wightman ◽  
Jonathon L. Reay ◽  
Crystal F. Haskell ◽  
Gary Williamson ◽  
Tristan P. Dew ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Performance ◽  
Human Subjects ◽  
Plasma Concentrations ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Flow Parameters ◽  
Within Subjects

Previous research has shown that resveratrol can increase cerebral blood flow (CBF) in the absence of improved cognitive performance in healthy, young human subjects during the performance of cognitively demanding tasks. This lack of cognitive effects may be due to low bioavailability and, in turn, reduced bioefficacy of resveratrol in vivo. Piperine can alter polyphenol pharmacokinetics, but previous studies have not investigated whether this affects the efficacy of the target compound. Therefore, the objective of the present study was to ascertain whether co-supplementation of piperine with resveratrol affects the bioavailability and efficacy of resveratrol with regard to cognition and CBF. The present study utilised a randomised, double-blind, placebo-controlled, within-subjects design, where twenty-three adults were given placebo, trans-resveratrol (250 mg) and trans-resveratrol with 20 mg piperine on separate days at least a week apart. After a 40 min rest/absorption period, the participants performed a selection of cognitive tasks and CBF was assessed throughout the period, in the frontal cortex, using near-IR spectroscopy. The presence of resveratrol and its conjugates in the plasma was confirmed by liquid chromatography–MS analysis carried out following the administration of the same doses in a separate cohort (n 6). The results indicated that when co-supplemented, piperine and resveratrol significantly augmented CBF during task performance in comparison with placebo and resveratrol alone. Cognitive function, mood and blood pressure were not affected. The plasma concentrations of resveratrol and its metabolites were not significantly different between the treatments, which indicates that co-supplementation of piperine with resveratrol enhances the bioefficacy of resveratrol with regard to CBF effects, but not cognitive performance, and does this without altering bioavailability.

scholarly journals Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation

2010 ◽  
Vol 91 (6) ◽  
pp. 1590-1597 ◽  
Author(s):  
David O Kennedy ◽  
Emma L Wightman ◽  
Jonathon L Reay ◽  
Georg Lietz ◽  
Edward J Okello ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Performance ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Flow Variables

Cognitive performance and cerebral blood flow in essential hypotension

2004 ◽  
Vol 41 (6) ◽  
pp. 905-913 ◽  
Author(s):  
Stefan Duschek ◽  
Rainer Schandry
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Performance

Neonatal Intracranial Hemorrhage and Phenobarbital

PEDIATRICS ◽  
1987 ◽  
Vol 79 (2) ◽  
pp. 315-315
Author(s):  
KARL C. K. KUBAN ◽  
ELIZABETH BROWN ◽  
ALAN LEVITON ◽  
KALPATHY KRISHNAMOORTHY
Keyword(s):  
Risk Factors ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Flow Pattern ◽  
Intracranial Hemorrhage ◽  
Double Blind Study ◽  
Inclusion Criteria ◽  
Blood Flow Pattern ◽  
Double Blind ◽  
Ultrasound Testing

In Reply.— We appreciate the comments by Dr Battisti et al. As noted in the inclusion criteria for our study,1 all intubated babies with birth weights less than 1,751 g were eligible for the study. One of the advantages of a randomized double-blind study is that babies with other risk factors, including presence of a fluctuating cerebral blood flow pattern on Doppler ultrasound testing, should have equal chances of being in the treated and placebo groups.

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