Melatonin reduces body weight gain and increases nocturnal activity in male Wistar rats

2013 ◽  
Vol 118 ◽  
pp. 8-13 ◽  
Author(s):  
M.P. Terrón ◽  
J. Delgado-Adámez ◽  
J.A. Pariente ◽  
C. Barriga ◽  
S.D. Paredes ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Wistar Rats ◽  
Body Weight Gain ◽  
Nocturnal Activity ◽  
Male Wistar Rats

scholarly journals Whey protein isolate and glycomacropeptide decrease weight gain and alter body composition in male Wistar rats

2008 ◽  
Vol 100 (1) ◽  
pp. 88-93 ◽  
Author(s):  
Peter J. Royle ◽  
Graeme H. McIntosh ◽  
Peter M. Clifton
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Weight Gain ◽  
Whey Protein ◽  
Wistar Rats ◽  
Body Weight Gain ◽  
Whey Protein Isolate ◽  
Protein Isolate ◽  
Whey Protein Concentrate ◽  
Protein Concentrate

The effect of feed protein type on body composition and growth has been examined. Evidence exists that whey protein concentrate is effective at limiting body fat expansion. The presence of caseinomacropeptide, a mixture of glycosylated and non-glycosylated carbohydrate residues, in particular glycomacropeptide (GMP) in whey protein concentrate may be important for this effect. The influence of whey protein isolate (WPI) and GMP on weight gain and body composition was examined by feeding Wistar rats ad libitum for 7 weeks with five semi-purified American Institute of Nutrition-based diets differing in protein type: (1) casein; (2) barbequed beef; (3) control WPI (no GMP); (4) WPI+GMP at 100 g/kg; (5) WPI+GMP at 200 g/kg. Body composition was assessed, and plasma samples were assayed for TAG, insulin and glucose. Body-weight gain was lower ( − 21 %) on the control WPI diet relative to casein, with a non-significant influence associated with GMP inclusion ( − 30 %), the effect being equivalent at both levels of GMP addition. Renal and carcass fat mass were reduced in the highest GMP diet when compared with WPI (P < 0·05). Plasma insulin was lowered by GMP at the highest addition compared with WPI alone ( − 53 %; P < 0·01). Plasma TAG in the WPI+GMP (200 g/kg) group were lower ( − 27 %; P < 0·05) than the casein and beef groups. In conclusion, GMP appears to have a significant additional influence when combined with WPI on fat accumulation. WPI alone appears to have the predominant influence accounting for 70 % of the overall effect on body-weight gain. Mechanisms for this effect have not been identified but food intake was not responsible.

scholarly journals Hypoglycaemic and anorexigenic activities of an α-amylase inhibitor from white kidney beans (Phaseolus vulgaris) in Wistar rats

2004 ◽  
Vol 92 (5) ◽  
pp. 785-790 ◽  
Author(s):  
M. A. Tormo ◽  
I. Gil-Exojo ◽  
A. Romero de Tejada ◽  
J. E. Campillo
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Phaseolus Vulgaris ◽  
Wistar Rats ◽  
Body Weight Gain ◽  
Insulin Response ◽  
Standard Diet ◽  
Glucose Levels ◽  
Amylase Inhibitor ◽  
Kidney Beans

An inhibitor of α-amylase was isolated and purified from an extract of white kidney beans (Phaseolus vulgaris). The acute oral administration of the inhibitor (50 mg/kg body weight) to adult Wistar rats together with a starch load (2 g/kg body weight suspended in NaCl (9 g/l)) reduced the increase in glycaemia over the basal value (NaCl, 222 (SEM 49); inhibitor, 145 (SEM 16) mmol/l×180 min; P<0.05) without modifying the insulin response. On administering the inhibitor orally (50 mg/kg body weight dissolved in NaCl (9 g/l)) for 21 d to rats fed on a standard diet, a decline was observed in the glycaemia values on day 0 (NaCl, 5.53 (SEM 0.12); inhibitor, 5.25 (SEM 0.16) mmol/l) relative to those obtained on days 10 (NaCl, 5.00 (SEM 0.14); inhibitor, 4.60 (SEM 0.08) mmol/l; P<0.05) and 21 (NaCl, 5.22 (SEM 0.22); inhibitor, 4.50 (SEM 0.12) mmol/l; P<0.01) of treatment, without modifying the plasma concentration of insulin. There was found to be a significant anorexigenic action of the inhibitor; there was reduced food intake (NaCl, 23.07 (SEM 0.31); inhibitor, 19.50 (SEM 0.49) g/d; P<0.01), a reduced weight gain (NaCl, 52 (SEM 3); inhibitor, −1.33 (SEM 8.9) g/21 d; P<0.01), as well as changes in the activity of some intestinal enzymes such as maltase (NaCl, 87 (SEM 7); inhibitor, 127 (SEM 11) U/g proteins; P<0.05). The present study has shown, for the first time, that the prolonged administration of an α-amylase inhibitor reduces blood glucose levels and body-weight gain in Wistar rats.

Effect of serum estradiol and leptin levels on thyroid function, food intake and body weight gain in female Wistar rats

Steroids ◽  
2010 ◽  
Vol 75 (10) ◽  
pp. 638-642 ◽  
Author(s):  
Thiago U. Pantaleão ◽  
Felippe Mousovich ◽  
Doris Rosenthal ◽  
Álvaro S. Padrón ◽  
Denise P. Carvalho ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Food Intake ◽  
Thyroid Function ◽  
Wistar Rats ◽  
Body Weight Gain ◽  
Serum Estradiol ◽  
Female Wistar Rats

Emblica officinalis – Anti-obesity activity

2017 ◽  
Vol 15 (2) ◽  
Author(s):  
Iram Nazish ◽  
Shahid H Ansari
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
High Fat Diet ◽  
Body Weight Gain ◽  
Density Lipoprotein ◽  
Oral Feeding ◽  
Emblica Officinalis ◽  
Traditional System ◽  
Obese Rats ◽  
Male Wistar Rats

Abstract Context Emblica officinalis Gaertn. (family-Phyllanthaceae) fruits, known commonly as amla, is extensively used in Indian traditional system of medicine for the treatment of various disorders. The ethanolic E. officinalis extract is reported to have various activity such as antidiabetic, antihyperlipidemic and antioxidant activity in experimental animals. Objective To evaluate anti-obesity effect of aqueous E. officinalis extract in murine model of high fat diet (HFD)-induced obesity. Materials and methods Male Wistar rats fed with HFD (20 g/day/rat, p.o) for a period of 42 days were used to induce obesity. Aqueous E. officinalis extract (20 mg/kg bw) administered orally to HFD-fed rats from day 8 to 50 days for a period of 42 days. Body weight gain, serum lipids, insulin and leptin parameters were measured. Results Oral feeding of the aqueous E. officinalis extract (20 mg/kg) to HFD-induced obese rats for a period of 42 days resulted in significant reduction in body weight gain, insulin, leptin, lipids as compared to rats fed HFD alone. Further, the extract also showed significant increase in high density lipoprotein (HDL-C) levels. Discussion and conclusions These results show that aqueous E. officinalis extract possess significant anti-obesity potential.

scholarly journals 3-O-β-D-Glucosyl-(1→6)-β-D-glucosyl-kaempferol Isolated from Sauropus androgenus Reduces Body Weight Gain in Wistar Rats

2006 ◽  
Vol 29 (12) ◽  
pp. 2510-2513 ◽  
Author(s):  
Shih-Fing Yu ◽  
Chia-Tung Shun ◽  
Tzer-Ming Chen ◽  
Yen-Hui Chen
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Wistar Rats ◽  
Body Weight Gain

scholarly journals Effects of Oral Administration of Monosodium Glutamate (MSG) on Obesity in Male Wistar Rats (Rattus Norvegicus)

2021 ◽  
Vol 5 (9) ◽  
pp. 879-882
Author(s):  
Mulyati Sri Rahayu ◽  
Sri Wahyuni ◽  
Yuziani
Keyword(s):  
Body Weight ◽  
Adult Male ◽  
Rattus Norvegicus ◽  
Wistar Rats ◽  
Body Weight Gain ◽  
Monosodium Glutamate ◽  
Control Group ◽  
Significant Difference ◽  
Male Wistar Rats ◽  
Group 2

Introduction: Monosodium glutamate (MSG) is one of the most widely employed food enhancers. Although the umami compound, controversy persists regarding the effects of MSG intake on body weight. Chronic MSG intake may result in excessive body weight gain and obesity. Consumption of MSG result in organ damage, cardiovascular disease, oxidative stress, and also risk factors for obesity. This study aims to determine the effect of oral MSG on obesity in adult male Wistar rats (Rattus norvegicus).Methods: This true experimental study used the post-test control group design. Twenty-four adult male Wistar rats were randomly divided into four groups: control (received distilled water), Group 1 (MSG 0.378 mg/gr BW), Group 2 (0.756 mg/gr BW) and Group 3 (1.512 mg/gr BW). The obesity parameter was obtained by the Lee index. Kruskal-Wallis test follows by Mann-Whitney test were used to compare the Lee index between groups.Results: Lee’s index mean for each group was 358.4%, 314.1%, 287.8%, and 320.9%, respectively. The Kruskal Wallis test showed a significant difference in the Lee index between groups (p = 0.043). A follow-up test using Mann-Whitney found a significant difference between group 2 and the control group (p = 0.043, p <0.05). The mean of Lee index of group 2 was 70.51% lower than the control group.Conclusion: This study concluded that Lee index was not increased in MSG-treated rats than in the control group after oral MSG intervention for 21 days.

scholarly journals Mitigating dietary aflatoxins in Wistar rat using selected phyto-antioxidant sources

2021 ◽  
Vol 48 (2) ◽  
pp. 38-52
Author(s):  
E. O. Ewuola ◽  
P. C. Emerue
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Wistar Rats ◽  
Body Weight Gain ◽  
Garlic Extract ◽  
Feed Conversion ◽  
Ginger Extract ◽  
Poids Corporel ◽  
Serum Biochemical ◽  
Carrot Extract

This study was conducted to investigate the mitigation of dietary aflatoxin in Wistar rats using extract from selected phyto-antioxidant sources. A total of one hundred and twenty Wistar rats weighing between 180-190g (80 females and 40 males) at six weeks old were allotted to eight treatments with 15 rats per treatment (10 females and 5 males), in a completely randomized design. The treatments were Treatment 1 (Normal diet + no extract and no aflatoxin), Treatment 2 (Aflatoxin contaminated diet + no extract), Treatment 3 (Aflatoxin contaminated diet + 100mg/kg BW Carrot extract), Treatment 4 (Aflatoxin contaminated diet + 200mg/kg BW Carrot extract), Treatment 5 (Aflatoxin contaminated diet + 100mg/kg BW Ginger extract), Treatment 6 (Aflatoxin contaminated diet + 200mg/kg BW Ginger extract), Treatment 7 (Aflatoxin contaminated diet +100mg/kg BW Garlic extract), Treatment 8 (Aflatoxin contaminated diet+ 200mg/kg BW Garlic extract). Body weight gain and feed conversion ratio of Wister rats (T8) administered 200 mg/kg BW was significant (p<0.05), with higher weight gain in male (206.00g) and female (199.70g). However, eviscerated and organs weights of both male and female Wistar rats was similar (p>0.05) across the treatments. Haematological and serum biochemical indices among the treatments was not significant (p>0.05), except for the globulin in male Wistar rats that differed significantly (p<0.05) with the value (5.00g/dL) being higher in T7. In conclusion, 200mg/kg body weight of garlic extract improved growth rate of Wistar rats, without any deleterious effect on haematological and serum biochemical parameters. Therefore, 200mg/kg body weight garlic extract mitigated the adverse effect of aflatoxin contaminated feed in Wistar rats.     Cette étude a été menée pour étudier l'atténuation de l'aflatoxine diététique chez les rats de 'Wistar' tout en employant l'extrait des sources phyto-antioxydantes choisies. Un total de cent vingt rats Wistar pesant entre 180 et 190 g (80 femelles et 40 mâles) à l'âge de six semaines ont été attribués à huit traitements avec 15 rats par traitement (10 femelles et 5 mâles), dans une conception complètement randomisée. Les traitements étaient le traitement 1 (régime normal + aucun extrait et aucune aflatoxine), traitement 2 (régime contaminé par l'aflatoxine + aucun extrait), traitement 3 (régime contaminé par l'aflatoxine + extrait de carotte BW de 100mg/kg), traitement 4 (régime contaminé par l'aflatoxine + extrait de carotte BW de 200mg/kg), traitement 5 (Aflatox alimentation contaminée par l'aflatoxine + extrait de gingembre BW 100mg/kg), Traitement 6 (régime contaminé à l'aflatoxine + extrait de gingembre BW 200mg/kg), Traitement 7 (régime contaminé par l'aflatoxine +100mg/kg extrait d'ail BW), Traitement 8 (régime contaminé à l'aflatoxine+ 200mg/kg extrait d'ail BW). Le gain de poids corporel et le rapport de conversion des aliments pour animaux des rats wisters (T8) administrés 200 mg/kg BW étaient significatifs (p<0.05), avec un gain de poids plus élevé chez les rats Wistar mâles (206.00 g) et femelles (199.70 g). Cependant, les poids éviscérés et organes des rats Wistar mâles et femelles étaient similaires (p>0.05) à travers les traitements. Les indices biochimiques hématologiques et sériques parmi les traitements n'étaient pas significatifs (p>0.05), à l'exception de la globuline chez les rats wistar mâles qui différait considérablement (p<0.05) avec la valeur (5.00 g/dL) étant plus élevée dans T7. En conclusion, le poids corporel de 200mg/kg de l'extrait d'ail a amélioré le taux de croissance des rats de Wistar, sans n'importe quel effet délétère sur les paramètres biochimiques hématologiques et sériques. Par conséquent, l'extrait d'ail de poids corporel de 200mg/kg a atténué l'effet défavorable de l'alimentation contaminée d'aflatoxin chez les rats de Wistar.

scholarly journals Empagliflozin Effectively Attenuates Olanzapine-Induced Body Weight Gain in Female Wistar Rats

2021 ◽  
Vol 12 ◽  
Author(s):  
Ghulam Md Ashraf ◽  
Badrah S. Alghamdi ◽  
Fahad S. Alshehri ◽  
Mohammad Zubair Alam ◽  
Haythum O. Tayeb ◽  
...  
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Body Weight Gain ◽  
Control Group ◽  
Male Control ◽  
Female Wistar Rats ◽  
Male Wistar Rats ◽  
Group 3 ◽  
Group 5 ◽  
Group 1

Atypical antipsychotic drugs are commonly associated with undesirable side effects including body weight gain (BWG) and metabolic deficits. Many pharmacological interventions have been tested in an attempt to minimize or prevent these side effects. Preliminary evidence suggests that antidiabetic drugs may be effective in attenuating antipsychotic-induced BWG. In the current study, we examined the effect of an antidiabetic drug empagliflozin (EMPA) on BWG induced by anatypical antipsychotic drug olanzapine (Ola) in female and male Wistar rats. Rats were divided into six groups based on the dose they received: group 1 (female control), group 2 (female EMPA, 20 mg/kg; IG), group 3 (female Ola, 4 mg/kg; IP), group 4 (female Ola, 4 mg/kg; IP + EMPA, 20 mg/kg; IG), group 5 (male control), and group 6 (male Ola, 4 mg/kg; IP). Ola induced sustained increase in BWG. The subsequent treatment of Group 3 and 4 with EMPA attenuated the Ola-induced BWG in female Wistar rats. In terms of the gender difference between female and male Wistar rats, the male control group 5 gained more weight throughout the study as compared to the female control group 1. Similarly, the male Ola group 6 gained more weight throughout the study as compared to the female Ola group 3. However, Ola did not cause any weight difference between male rats treated with Ola in comparison with male control group, thus showing a significant gender difference regarding body weight between male and female Wistar rats regardless of Ola administration. In addition, the present findings showed that EMPA effectively attenuates the Ola induced BWG in female Wistar rats. These novel findings should help to better understand the underlying molecular and behavioral mechanisms contributing to the observed increase in body weight after treatment with Ola and other atypical antipsychotic drugs across male and female rats.

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