Availability of a rich source of sodium during the perinatal period programs the fluid balance restoration pattern in adult offspring

2012 ◽  
Vol 105 (4) ◽  
pp. 1035-1044 ◽  
Author(s):  
A.F. Macchione ◽  
X.E. Caeiro ◽  
A. Godino ◽  
J.L. Amigone ◽  
J. Antunes-Rodrigues ◽  
...  
Keyword(s):  
Fluid Balance ◽  
Perinatal Period ◽  
Rich Source ◽  
Adult Offspring

scholarly journals Dyslipidemia in adult offspring induced by high fat diet rats at perinatal period.

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Mario Matiotti Neto ◽  
Robervan Vidal Santos ◽  
Vitor Ulisses Melo ◽  
Fabrício Macedo ◽  
José Luiz Brito Alves ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Perinatal Period ◽  
Adult Offspring ◽  
High Fat

scholarly journals Varying Protein Quantity and Quality in the Maternal Diet During the Perinatal Period Affects Growth and Adiposity Risk in Female Adult Offspring in Rats (OR09-03-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Gabrielle Carlin ◽  
Catherine Chaumontet ◽  
Corine Delteil ◽  
Andrea Kodde ◽  
Bert van de Heijning ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Weight Gain ◽  
Dietary Protein ◽  
Plasma Insulin ◽  
Maternal Diet ◽  
Perinatal Period ◽  
Protein Source ◽  
Adult Offspring ◽  
Tissue Weight ◽  
Adipose Tissue Weight

Abstract Objectives Maternal diet in the perinatal period can program health of adult offspring. This study evaluates the consequences of maternal dietary protein quality and quantity during gestation and lactation on overweight risk in female offspring subjected to dietary self-selection (DSS). Methods Six groups of rat dams were fed a high-protein (HP; 47% protein) or normal protein (NP; 19% protein) isocaloric diet during gestation. Protein sources of HP and NP diets were either milk (M), pea (P), or turkey (T)-derived. During lactation, dams were fed NP diet containing the protein source as fed during pregnancy. From postnatal day (PND) 28 to 70, pups (n = 8 per group) were exposed to DSS with a choice between five cups containing either: HP-M, HP-P, HP-T diets, or only carbohydrates or only lipids. Pups’ weight gain and food intake were recorded daily. Body composition, fasting plasma insulin and leptin levels were assessed at the end of the study (PND70). Results During lactation, pups’ weight gain was lower in the “turkey and pea” compared to “milk” group (P < 0.0001), resulting in a lower weight gain in the “pea” compared to “milk” group at the end of the lactation period (PND28; P < 0.0001). Body weight gain from PND28 to 70 was also lower in the “pea and turkey “compared to “milk” group (P < 0.0001). Total food intake throughout the postweaning period, was lower in the “pea and turkey” compared to “milk” group (P < 0.05). At PND70, body composition was affected by (i) the maternal protein source showing a lower adipose tissue weight in the “pea and turkey” compared to “milk” group (P = 0.01), but also by (ii) the maternal protein quantity showing increased adipose tissue weight (≥16%) in HP compared to NP gestation groups (P = 0.03) (figure 1), regardless of the protein source in the maternal diet. In accordance with the increased adipose tissue weight in HP groups, fasting plasma leptin levels were significantly higher in HP compared to NP gestation groups (P < 0.05). Plasma insulin levels were not affected. Conclusions Dietary protein source during gestation and lactation directly affected weight gain of the offspring after weaning and at adulthood. HP diet during gestation resulted in a higher adiposity in the offspring, independent of the protein source. Funding Sources This thesis work was partly funded by Danone Nutricia Research. Supporting Tables, Images and/or Graphs

Ultrastructural alterations in the fetal mouse myocardium in response to genetic and environmental factors

1987 ◽  
Vol 45 ◽  
pp. 724-725
Author(s):  
K.C. Feng-Chen ◽  
F.B. Essien ◽  
K.J. Prestwidge ◽  
J.T. Cheng ◽  
C.L. Shen
Keyword(s):  
Fetal Heart ◽  
Perinatal Period ◽  
Primary Energy ◽  
Cardiac Contraction ◽  
Ultrastructural Changes ◽  
Fetal Mouse ◽  
The Subject ◽  
Physiological Adjustments ◽  
Genetic And Environmental Factors ◽  
Genetically Determined

The physiology of the fetal heart differs significantly from that of the mature post-natal organ: e.g., the metabolic supply for adult cardiac contraction relies mainly on fatty acids; whereas, the fetal heart uses carbohydrates as its primary energy source. Limited morphological descriptions of the developing myocardium have appeared. However, additional studies are required to elucidate the ultrastructural changes occuring in the perinatal period when enormous physiological adjustments are made. Although adult animals are most often used in toxocological and pathological analyses, it is also important to investigate fetal cardiac responsiveness to various agents. The vulnerability of the ultrastructure of the fetal mouse myocardium to genetic and environmental assault is the subject of this report. The genetically determined effect on the heart was observed in mouse embryos homozygous for the cab (cardiac abnormality) mutation discovered by Essien.

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