scholarly journals Developmental exposure to a serotonin agonist produces subsequent behavioral and neurochemical changes in the adult male prairie vole

2012 ◽  
Vol 105 (2) ◽  
pp. 529-535 ◽  
Author(s):  
Melissa M. Martin ◽  
Yan Liu ◽  
Zuoxin Wang
Keyword(s):  
Adult Male ◽  
Prairie Vole ◽  
Developmental Exposure ◽  
Serotonin Agonist ◽  
Neurochemical Changes

scholarly journals Nucleus accumbens core medium spiny neuron electrophysiological properties and partner preference behavior in the adult male prairie vole, Microtus ochrogaster

2018 ◽  
Vol 119 (4) ◽  
pp. 1576-1588 ◽  
Author(s):  
Jaime A. Willett ◽  
Ashlyn G. Johnson ◽  
Andrea R. Vogel ◽  
Heather B. Patisaul ◽  
Lisa A. McGraw ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Social Behavior ◽  
Adult Male ◽  
Prairie Vole ◽  
Medium Spiny Neuron ◽  
Partner Preference ◽  
Nucleus Accumbens Core ◽  
Electrophysiological Properties ◽  
Preference Behavior ◽  
Accumbens Core

Medium spiny neurons (MSNs) in the nucleus accumbens have long been implicated in the neurobiological mechanisms that underlie numerous social and motivated behaviors as studied in rodents such as rats. Recently, the prairie vole has emerged as an important model animal for studying social behaviors, particularly regarding monogamy because of its ability to form pair bonds. However, to our knowledge, no study has assessed intrinsic vole MSN electrophysiological properties or tested how these properties vary with the strength of the pair bond between partnered voles. Here we performed whole cell patch-clamp recordings of MSNs in acute brain slices of the nucleus accumbens core (NAc) of adult male voles exhibiting strong and weak preferences for their respective partnered females. We first document vole MSN electrophysiological properties and provide comparison to rat MSNs. Vole MSNs demonstrated many canonical electrophysiological attributes shared across species but exhibited notable differences in excitability compared with rat MSNs. Second, we assessed male vole partner preference behavior and tested whether MSN electrophysiological properties varied with partner preference strength. Male vole partner preference showed extensive variability. We found that decreases in miniature excitatory postsynaptic current amplitude and the slope of the evoked action potential firing rate to depolarizing current injection weakly associated with increased preference for the partnered female. This suggests that excitatory synaptic strength and neuronal excitability may be decreased in MSNs in males exhibiting stronger preference for a partnered female. Overall, these data provide extensive documentation of MSN electrophysiological characteristics and their relationship to social behavior in the prairie vole. NEW & NOTEWORTHY This research represents the first assessment of prairie vole nucleus accumbens core medium spiny neuron intrinsic electrophysiological properties and probes the relationship between cellular excitability and social behavior.

Sex-Specific Disruption of the Prairie Vole Hypothalamus by Developmental Exposure to a Flame Retardant Mixture

Endocrinology ◽  
2021 ◽  
Author(s):  
Sagi Enicole A Gillera ◽  
William P Marinello ◽  
Kevin T Cao ◽  
Brian M Horman ◽  
Heather M Stapleton ◽  
...  
Keyword(s):  
Flame Retardants ◽  
Prairie Vole ◽  
Zona Incerta ◽  
Prairie Voles ◽  
Behavioral Deficits ◽  
Developmental Exposure ◽  
Neuronal Populations ◽  
Increased Risk ◽  
Osmotic Balance ◽  
Multiple Species

Abstract Prevalence of neurodevelopmental disorders (NDDs) with social deficits is conspicuously rising, particularly in boys. Flame retardants (FRs) have long been associated with increased risk, and prior work by us and others in multiple species has shown that developmental exposure to the common FR mixture Firemaster 550 (FM 550) sex-specifically alters socioemotional behaviors including anxiety and pair bond formation. In rats, FRs have also been shown to impair aspects of osmoregulation. Because vasopressin (AVP) plays a role in both socioemotional behavior and osmotic balance we hypothesized that AVP and its related nonapeptide oxytocin (OT) would be vulnerable to developmental FM 550 exposure. We used the prairie vole (Microtus ochrogaste) to test this because it is spontaneously prosocial. Using siblings of prairie voles used in a prior study that assessed behavioral deficits resulting from developmental FM 550 exposure across three doses, here we tested the hypothesis that FM 550 sex-specifically alters AVP and OT neuronal populations in critical nuclei, such as the paraventricular nucleus (PVN) that coordinate those behaviors, as well as related dopaminergic (determined by tyrosine hydroxylase (TH) immunolabeling) populations. Exposed females had fewer AVP neurons in the anterior PVN and more A13 TH neurons in the zona incerta compared to controls. By contrast, in FM 550 males, A13 TH neuron numbers in the zona incerta were decreased but only in one dose group. These results expand on previous work showing evidence of endocrine disruption of OT/AVP pathways, including to subpopulations of PVN AVP neurons that coordinate osmoregulatory functions in the periphery.

Neurobehavioral Alteration in Rodents Following Developmental Exposure To Aluminum

1998 ◽  
Vol 14 (1-2) ◽  
pp. 209-221 ◽  
Author(s):  
Enrico Alleva ◽  
Judith Rankin ◽  
Daniela Santucci
Keyword(s):  
Learning Task ◽  
Maze Learning ◽  
Ultrasonic Vocalizations ◽  
Laboratory Animals ◽  
Developmental Exposure ◽  
Adult Mice ◽  
Pathological Conditions ◽  
Soil Exposure ◽  
Neurochemical Changes ◽  
Choline Acetyltransferase Activity

Aluminum (Al) is one of the most abundant metals in the earth's crust, and humans can be exposed to it from several sources. It is present in food, water, pharmaceutical compounds, and in the environment, e.g., as a result of acid rain leaching it from the soil. Exposure to Al has recently been implicated in a number of human pathologies, but it has not yet been definitely proved that it plays a major causal role in any of them. In this paper we review the effects of developmental exposure of laboratory animals to Al salts as a model for human pathological conditions. The data presented show behavioral and neurochemical changes in the offspring of AL-exposed mouse dams during gestation, which include alterations in the pattern of ultrasonic vocalizations and a marked reduction in central nervous system (CNS) choline acetyltransferase activity. Prenatal Al also affects CNS cholinergic functions under Nerve Growth Factor (NGF) control, as shown by increased central NGF levels and impaired performances in a maze learning task in young-adult mice. The need for more detailed studies to evaluate the risks for humans associated with developmental exposure to Al, as well as the importance of using more than one strain of laboratory animal in the experimental design, is emphasized.

Developmental exposure to mancozeb induced neurochemical and morphological alterations in adult male mouse hypothalamus

2018 ◽  
Vol 64 ◽  
pp. 139-146
Author(s):  
Yasmin Morales-Ovalles ◽  
Leticia Miranda-Contreras ◽  
Zulma Peña-Contreras ◽  
Delsy Dávila-Vera ◽  
Alirio Balza-Quintero ◽  
...  
Keyword(s):  
Adult Male ◽  
Male Mouse ◽  
Developmental Exposure ◽  
Morphological Alterations ◽  
Adult Male Mouse

scholarly journals ChIP-Seq analysis of the adult male mouse brain after developmental exposure to arsenic

Data in Brief ◽  
2015 ◽  
Vol 5 ◽  
pp. 248-254 ◽  
Author(s):  
Christina R. Tyler ◽  
Jessica A. Weber ◽  
Matthew Labrecque ◽  
Justin M. Hessinger ◽  
Jeremy S. Edwards ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Adult Male ◽  
Male Mouse ◽  
Developmental Exposure ◽  
Adult Male Mouse
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