Sex differences in anxiety-like behavior and locomotor activity following prenatal and postnatal methamphetamine exposure in adult rats

2012 ◽  
Vol 105 (2) ◽  
pp. 364-370 ◽  
Author(s):  
L. Hrubá ◽  
B. Schutová ◽  
R. Šlamberová
Keyword(s):  
Sex Differences ◽  
Locomotor Activity ◽  
Adult Rats

Physical exercise protects dynamic balance and motor coordination of rats treated with vincristine

2020 ◽  
Vol 19 (5) ◽  
pp. 336
Author(s):  
Luiza Minato Sagrillo ◽  
Viviane Nogueira De Zorzi ◽  
Luiz Fernando Freire Royes ◽  
Michele Rechia Fighera ◽  
Beatriz Da Silva Rosa Bonadiman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Locomotor Activity ◽  
Physical Exercise ◽  
Motor Coordination ◽  
Dynamic Balance ◽  
Exercise Group ◽  
Adult Rats ◽  
The Central Nervous System ◽  
Stress Damage ◽  
Training Protocol

Physical exercise has been shown to be an important modulator of the antioxidant system and neuroprotective in several diseases and treatments that affect the central nervous system. In this sense, the present study aimed to evaluate the effect of physical exercise in dynamic balance, motor coordination, exploratory locomotor activity and in the oxidative and immunological balance of rats treated with vincristine (VCR). For that, 40 adult rats were divided into two groups: exercise group (6 weeks of swimming, 1h/day, 5 days/week, with overload of 5% of body weight) and sedentary group. After training, rats were treated with 0.5 mg/kg of vincristine sulfate for two weeks or with the same dose of 0.9% NaCl. The behavioral tests were conducted 1 and 7 days after each dose of VCR. On day 15 we carried out the biochemical analyzes of the cerebellum. The physical exercise was able to protect against the loss of dynamic balance and motor coordination and, had effect per se in the exploratory locomotor activity, and neutralize oxidative stress, damage DNA and immune damage caused by VCR up to 15 days after the end of the training protocol. In conclusion, we observed that previous physical training protects of the damage motor induced by vincristine.Key-words: exercise, oxidative stress, neuroprotection, cerebellum.

scholarly journals Comparison of caffeine-induced locomotor activity between adolescent and adult rats

2011 ◽  
Vol 660 (2-3) ◽  
pp. 363-367 ◽  
Author(s):  
Marcelo T. Marin ◽  
Roberta Zancheta ◽  
Ana H. Paro ◽  
Ana P.M. Possi ◽  
Fábio C. Cruz ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Adult Rats

scholarly journals Sex differences in anxiety-like behavior and locomotor activity following chronic nicotine exposure in mice

2008 ◽  
Vol 439 (2) ◽  
pp. 187-191 ◽  
Author(s):  
Barbara J. Caldarone ◽  
Sarah L. King ◽  
Marina R. Picciotto
Keyword(s):  
Sex Differences ◽  
Locomotor Activity ◽  
Nicotine Exposure ◽  
Chronic Nicotine

scholarly journals Diazepam attenuates the effects of cocaine on locomotion, 50-kHz ultrasonic vocalizations and phasic dopamine release in the nucleus accumbens of rats

2020 ◽  
Author(s):  
William N. Sanchez ◽  
Jose A. Pochapski ◽  
Leticia F. Jessen ◽  
Marek Ellenberger ◽  
Rainer K. Schwarting ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Nucleus Accumbens ◽  
Dopamine Release ◽  
Ultrasonic Vocalizations ◽  
Control Group ◽  
List Type ◽  
Adult Rats ◽  
Fast Scan Cyclic Voltammetry ◽  
Entire Duration ◽  
Male Wistar Rats

AbstractBackground and PurposeCurrently, no effective drug exists to treat cocaine use disorders, which affect millions of people worldwide. Benzodiazepines are potential therapeutic candidates, as microdialysis and voltammetry studies have shown that they can decrease dopamine release in the nucleus accumbens of rodents. In addition, we have recently shown that diazepam blocks the increase in dopamine release and the affective marker 50-kHz ultrasonic vocalizations (USV) induced by DL-amphetamine in rats.Experimental ApproachHere we tested whether administration of 2.5 mg·kg−1 diazepam (i.p.) in adult male Wistar rats could block the effects of 20 mg·kg−1 cocaine (i.p.) on electrically evoked phasic dopamine release in the nucleus accumbens measured by fast-scan cyclic voltammetry, as well as 50-kHz USV and locomotor activity.Key ResultsCocaine injection increased evoked dopamine release up to 3-fold within 5 min and the increase was significantly higher than baseline for at least 90 min. The injection of diazepam 15 min later attenuated the cocaine effect by nearly 50% and this attenuation was maintained for at least 30 min. Stimulant drugs, natural rewards and reward predictive cues are known to evoke 50-kHz USV in adult rats. In the present study, cocaine increased the number of 50-kHz USV of the flat, step, trill, and mixed kinds by 12-fold. This effect was at maximum 5 min after cocaine injection, decreased with time and lasted at least 40 min. Diazepam significantly blocked this effect for the entire duration of the session. The distance travelled by control rats during a 40-min session of exploration in an open field was at maximum in the first 5 min and decayed progressively until the end of the session. Cocaine-treated rats travelled significantly longer distances when compared to the control group, while diazepam significantly attenuated cocaine-induced locomotion by up to 50%.Conclusions and implicationThese results suggest that the neurochemical, affective, and stimulant effects of cocaine can be mitigated by diazepam.What is already knownDiazepam decreases dopamine release in the rodent nucleus accumbens (NAc) and reduces some effects produced by DL-amphetamine.What this study addsDiazepam attenuated the increase in phasic dopamine release caused by cocaine.Diazepam blocked the effect of cocaine on 50-kHz USV and locomotor activity.Clinical significanceThis study demonstrates that diazepam can block specific effects of cocaine that likely contribute to addiction.

scholarly journals Sex-dependent changes in ketamine-induced locomotor activity and ketamine pharmacokinetics in preweanling, adolescent, and adult rats

2019 ◽  
Vol 29 (6) ◽  
pp. 740-755 ◽  
Author(s):  
Sanders A. McDougall ◽  
Ginny I. Park ◽  
Goretti I. Ramirez ◽  
Vanessa Gomez ◽  
Brittnee C. Adame ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Adult Rats

P.579 Sex differences in depressive-like behavior in adult rats subjected to early life stress

2019 ◽  
Vol 29 ◽  
pp. S405
Author(s):  
N. Broshevitskaya ◽  
I. Pavlova ◽  
M. Zaichenko ◽  
V. Gruzdeva ◽  
G. Grigoryan
Keyword(s):  
Sex Differences ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Adult Rats

Facilitation of Dopamine-Mediated Locomotor Activity in Adult Rats following Cholinergic Denervation

2002 ◽  
Vol 174 (1) ◽  
pp. 96-108 ◽  
Author(s):  
Anna Mattsson ◽  
Sven Ove Ögren ◽  
Lars Olson
Keyword(s):  
Locomotor Activity ◽  
Adult Rats
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