The autonomic stress-induced hyperthermia response is not enhanced by several anxiogenic drugs

2011 ◽  
Vol 102 (1) ◽  
pp. 105-109 ◽  
Author(s):  
Lotte C. Houtepen ◽  
Daniëlle P. Peterse ◽  
Koen G.C. Westphal ◽  
Berend Olivier ◽  
Christiaan H. Vinkers
Keyword(s):  
Induced Hyperthermia ◽  
Anxiogenic Drugs

scholarly journals Tempol Treatment Reduces Anxiety-Like Behaviors Induced by Multiple Anxiogenic Drugs in Rats

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0117498 ◽  
Author(s):  
Gaurav Patki ◽  
Ankita Salvi ◽  
Hesong Liu ◽  
Fatin Atrooz ◽  
Isam Alkadhi ◽  
...  
Keyword(s):  
Anxiogenic Drugs

Microwave-induced hyperthermia in cancer treatment: Apparatus and preliminary results

1978 ◽  
Vol 4 (11-12) ◽  
pp. 1095-1103 ◽  
Author(s):  
Jozef Mendecki ◽  
Esther Friedenthal ◽  
Charles Botstein ◽  
Fred Sterzer ◽  
Robert Paglione ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Preliminary Results ◽  
Induced Hyperthermia

scholarly journals Influence of dietary fats on ecstasy-induced hyperthermia

2007 ◽  
Vol 151 (7) ◽  
pp. 1103-1108 ◽  
Author(s):  
E M Mills ◽  
K L Weaver ◽  
E Abramson ◽  
M Pfeiffer ◽  
J E Sprague
Keyword(s):  
Dietary Fats ◽  
Induced Hyperthermia

The hyperthermic effect of central cholecystokinin is mediated by the cyclooxygenase-2 pathway

2021 ◽  
Author(s):  
Patrik Keringer ◽  
Nora Furedi ◽  
Balazs Gaszner ◽  
Alexandra Miko ◽  
Eszter Pakai ◽  
...  
Keyword(s):  
Body Temperature ◽  
Enzyme Inhibitor ◽  
Core Body Temperature ◽  
Ventromedial Hypothalamus ◽  
Neuronal Activation ◽  
Hypothalamic Area ◽  
Induced Hyperthermia ◽  
Male Wistar Rats ◽  
Cox 2 ◽  
Fever Response

Cholecystokinin (CCK) increases core body temperature via CCK2 receptors when administered intracerebroventricularly (icv). The mechanisms of CCK-induced hyperthermia are unknown, and it is also unknown whether CCK contributes to the fever response to systemic inflammation. We studied the interaction between central CCK signaling and the cyclooxygenase (COX) pathway. Body temperature was measured in adult male Wistar rats pretreated with intraperitoneal infusion of the nonselective COX enzyme inhibitor metamizol (120 mg/kg) or a selective COX-2 inhibitor, meloxicam or etoricoxib (10 mg/kg for both) and, 30 minutes later, treated with icv CCK (1.7 µg/kg). In separate experiments, CCK-induced neuronal activation (with and without COX inhibition) was studied in thermoregulation- and feeding-related nuclei with c-Fos immunohistochemistry. CCK increased body temperature by ~0.4°C from 10 min post-infusion, which was attenuated by metamizol. CCK reduced the number of c-Fos-positive cells in the median preoptic area (by ~70%) but increased it in the dorsal hypothalamic area and in the rostral raphe pallidus (by ~50% in both); all these changes were all completely blocked with metamizol. In contrast, CCK-induced satiety and neuronal activation in the ventromedial hypothalamus were not influenced by metamizol. CCK-induced hyperthermia was also completely blocked with both selective COX-2 inhibitors studied. Finally, the CCK2 receptor antagonist YM022 (10 µg/kg; icv) attenuated the late phases of fever induced by bacterial lipopolysaccharide (10 µg/kg; intravenously). We conclude that centrally administered CCK causes hyperthermia through changes in the activity of "classical" thermoeffector pathways, and that the activation of COX-2 is required for the development of this response.

Optimum morphology of gold nanorods for light-induced hyperthermia

Nanoscale ◽  
2018 ◽  
Vol 10 (5) ◽  
pp. 2632-2638 ◽  
Author(s):  
Jordi Morales-Dalmau ◽  
Clara Vilches ◽  
Ignacio de Miguel ◽  
Vanesa Sanz ◽  
Romain Quidant
Keyword(s):  
Gold Nanorods ◽  
Systematic Study ◽  
Gold Nanorod ◽  
Cellular Toxicity ◽  
Induced Hyperthermia

A systematic study of the influence of gold nanorod morphology on cellular toxicity, uptake and light to heat conversion.

scholarly journals Non-Invasive Assessment of Mild Stress-Induced Hyperthermia by Infrared Thermography in Laboratory Mice

Animals ◽  
2022 ◽  
Vol 12 (2) ◽  
pp. 177
Author(s):  
Urša Blenkuš ◽  
Ana Filipa Gerós ◽  
Cristiana Carpinteiro ◽  
Paulo de Castro Aguiar ◽  
I. Anna S. Olsson ◽  
...  
Keyword(s):  
Infrared Thermography ◽  
Core Body Temperature ◽  
Mild Stress ◽  
Laboratory Mice ◽  
Induced Hyperthermia ◽  
Non Invasive ◽  
Body Regions ◽  
Plus Maze ◽  
Core Body ◽  
Typical Temperature

Stress-induced hyperthermia (SIH) is a physiological response to acute stressors in mammals, shown as an increase in core body temperature, with redirection of blood flow from the periphery to vital organs. Typical temperature assessment methods for rodents are invasive and can themselves elicit SIH, affecting the readout. Infrared thermography (IRT) is a promising non-invasive alternative, if shown to accurately identify and quantify SIH. We used in-house developed software ThermoLabAnimal 2.0 to automatically detect and segment different body regions, to assess mean body (Tbody) and mean tail (Ttail) surface temperatures by IRT, along with temperature (Tsc) assessed by reading of subcutaneously implanted PIT-tags, during handling-induced stress of pair-housed C57BL/6J and BALB/cByJ mice of both sexes (N = 68). SIH was assessed during 10 days of daily handling (DH) performed twice per day, weekly voluntary interaction tests (VIT) and an elevated plus maze (EPM) at the end. To assess the discrimination value of IRT, we compared SIH between tail-picked and tunnel-handled animals, and between mice receiving an anxiolytic drug or vehicle prior to the EPM. During a 30 to 60 second stress exposure, Tsc and Tbody increased significantly (p < 0.001), while Ttail (p < 0.01) decreased. We did not find handling-related differences. Within each cage, mice tested last consistently showed significantly higher (p < 0.001) Tsc and Tbody and lower (p < 0.001) Ttail than mice tested first, possibly due to higher anticipatory stress in the latter. Diazepam-treated mice showed lower Tbody and Tsc, consistent with reduced anxiety. In conclusion, our results suggest that IRT can identify and quantify stress in mice, either as a stand-alone parameter or complementary to other methods.

Stress-induced hyperthermia as a putative anxiety model

1995 ◽  
Vol 294 (1) ◽  
pp. 125-135 ◽  
Author(s):  
Theo J.J. Zethof ◽  
Jan A.M. Van Der Heyden ◽  
Jeroen T.B.M. Tolboom ◽  
Berend Olivier
Keyword(s):  
Induced Hyperthermia
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