Long-term physiological and behavioral effects of exposure to a highly palatable diet during the perinatal and post-weaning periods

2010 ◽  
Vol 101 (4) ◽  
pp. 494-502 ◽  
Author(s):  
Uri Shalev ◽  
Alana Tylor ◽  
Kristin Schuster ◽  
Claudia Frate ◽  
Stephanie Tobin ◽  
...  
Keyword(s):  
Behavioral Effects ◽  
Palatable Diet ◽  
Highly Palatable Diet

Early programming of weight gain in mice prevents the induction of obesity by a highly palatable diet

2004 ◽  
Vol 106 (2) ◽  
pp. 141-145 ◽  
Author(s):  
Susan E. OZANNE ◽  
Rohan LEWIS ◽  
Bridget J. JENNINGS ◽  
C. Nicholas HALES
Keyword(s):  
Weight Gain ◽  
Subsequent Development ◽  
Free Access ◽  
Early Environment ◽  
Thrifty Phenotype ◽  
Low Protein ◽  
The Metabolic Syndrome ◽  
Palatable Diet ◽  
Highly Palatable Diet

Poor early growth is associated with Type II diabetes, hypertension and other features of the metabolic syndrome in adulthood. It has been suggested that this results from the development of a thrifty phenotype by a malnourished fetus. Such a phenotype would predispose the offspring to the development of obesity if born into conditions of over-nutrition. The present study aimed to determine if early nutrition affected subsequent development of obesity. Mice were established as follows: (a) controls (offspring of control dams), (b) recuperated (offspring of dams fed a low-protein diet during pregnancy, but nursed by control dams) and (c) postnatal low-protein (offspring of control dams nursed by low-protein-fed dams). Mice were weaned on to standard laboratory chow or a cafeteria diet. Recuperated offspring, although smaller at birth (P<0.01), caught up and exceeded the weight of control offspring by 7 days of age (P<0.001). Postnatal low-protein offspring were smaller than controls by 7 days of age (P<0.001). Recuperated animals gained more weight than controls when given free access to a highly palatable diet (P<0.01). Postnatal low-protein animals showed no additional weight gain when given a highly palatable diet compared with chow-fed litter-mates. These results suggest that the early environment has long-term consequences for weight gain. These programmed responses are powerful enough to block excess weight gain from a highly palatable diet and, thus, have major implications for the drug-free regulation of food intake and obesity.

scholarly journals Highly palatable diet changes brain glucose metabolism in mice

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Sarah Wehle Gehres ◽  
Andreia Silva da Rocha ◽  
Yuri Elias Rodrigues ◽  
Guilherme G Schu Peixoto ◽  
Afonso Kopczynski Carvalho ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Brain Glucose ◽  
Brain Glucose Metabolism ◽  
Palatable Diet ◽  
Highly Palatable Diet

Long term neurological and behavioral effects of graded perinatal asphyxia in the rat

Life Sciences ◽  
2000 ◽  
Vol 66 (10) ◽  
pp. 947-962 ◽  
Author(s):  
Harald Hoeger ◽  
Mario Engelmann ◽  
Guenther Bernert ◽  
Rainer Seidl ◽  
Hermann Bubna-Littitz ◽  
...  
Keyword(s):  
Perinatal Asphyxia ◽  
Behavioral Effects

Immediate and long-term behavioral effects of a single nicotine injection in adolescent and adult rats

2007 ◽  
Vol 29 (1) ◽  
pp. 74-80 ◽  
Author(s):  
Jennifer M. Brielmaier ◽  
Craig G. McDonald ◽  
Robert F. Smith
Keyword(s):  
Behavioral Effects ◽  
Adult Rats

scholarly journals An Investigation of the Long and Short Term Behavioral Effects of General Anesthesia on Pediatric Dental Patients With Autism

2021 ◽  
Vol 2 ◽  
Author(s):  
Janine Tran ◽  
Jung-Wei Chen ◽  
Larry Trapp ◽  
Laura McCormack
Keyword(s):  
General Anesthesia ◽  
Sleep Disturbances ◽  
Activity Level ◽  
Behavioral Effects ◽  
Healthy Children ◽  
Post Discharge ◽  
Dental Surgery ◽  
Dental Patients ◽  
Post Surgery

Purpose: The purpose of this study was to compare the incidence of short and long term adverse behavioral effects of general anesthesia (GA) in healthy vs. moderate to severe autistic (ASD) children.Methods: Forty healthy and 37 ASD children, aged 3–17 years, undergoing GA for dental surgery participated in this study. Their anesthesia records were reviewed, and their parents answered telephone surveys to assess activity level, sleep disturbances, gastrointestinal disturbances, central nervous system effects, and respiratory depression. Three follow-up surveys were taken 8 h, 24 h, and 3 months post-surgery.Results: Four hundred fifty-five incidences of adverse behavioral effects occurred within 8 h post-surgery. Significantly more ASD patients had difficulty walking (P = 0.016) and nausea (P = 0.030), while more healthy children snored in the car ride home (P = 0.036) and talked about the dental surgery (P = 0.027). Three months post-discharge, sixASD patients acted in a way that concerned caregivers compared to 0 healthy patients, (P = 0.008). Incidence of adverse behavioral effects significantly decreased from 8 to 24 h overall.Conclusions: Most behavioral effects occur within 8 h post-surgery. There are potential long term adverse behavioral effects in ASD children from GA, but the chance is low and generally not long lasting.

Neonatal locomotor and long-term behavioral effects of d-amphetamine in the rat

1975 ◽  
Vol 8 (3) ◽  
pp. 241-250 ◽  
Author(s):  
Sonya K. Sobrian ◽  
Mardi Weltman ◽  
Bruce A. Pappas
Keyword(s):  
Behavioral Effects

The long-term behavioral effects of exposure to metals and chronic stress during development

2010 ◽  
Vol 32 (4) ◽  
pp. 498-499
Author(s):  
Devon Graham ◽  
Robyn Amos-Kroohs ◽  
Amanda Braun ◽  
Curtis Grace ◽  
Tori Schaefer ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Behavioral Effects

Long-term increase in sensitivity to ketamine's behavioral effects in mice exposed to mild blast induced traumatic brain injury

2021 ◽  
pp. 113963
Author(s):  
Caroline A. Browne ◽  
B.A. Hildegard A Wulf ◽  
Moriah L. Jacobson ◽  
Mario Oyola ◽  
T. John Wu ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Behavioral Effects
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