Portal hypertension in 18-month-old rats: Memory deficits and brain metabolic activity

2010 ◽  
Vol 100 (2) ◽  
pp. 135-142 ◽  
Author(s):  
Azucena Begega ◽  
Marta Méndez ◽  
Sandra Rubio ◽  
Luis J. Santín ◽  
María A. Aller ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Metabolic Activity ◽  
Memory Deficits ◽  
Old Rats ◽  
Brain Metabolic Activity

scholarly journals Acetyl-l-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity

1998 ◽  
Vol 95 (16) ◽  
pp. 9562-9566 ◽  
Author(s):  
Tory M. Hagen ◽  
Russell T. Ingersoll ◽  
Carol M. Wehr ◽  
Jens Lykkesfeldt ◽  
Vladimir Vinarsky ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Activity ◽  
Mitochondrial Function ◽  
Mitochondrial Membrane ◽  
Ambulatory Activity ◽  
General Measure ◽  
Cellular Oxygen ◽  
Old Rats ◽  
Oxidant Production ◽  
Parenchymal Cells

Mitochondrial function and ambulatory activity were monitored after feeding old rats acetyl-l-carnitine (ALCAR). Young (3–5 mo) and old (22–28 mo) rats were given a 1.5% (wt/vol) solution of ALCAR in their drinking water for 1 mo, were sacrificed, and their liver parenchymal cells were isolated. ALCAR supplementation significantly reverses the age-associated decline of mitochondrial membrane potential, as assessed by rhodamine 123 staining. Cardiolipin, which declines significantly with age, is also restored. ALCAR increases cellular oxygen consumption, which declines with age, to the level of young rats. However, the oxidant production per oxygen consumed, as measured by 2′,7′-dichlorofluorescin fluorescence levels, is ≈30% higher than in untreated old rats. Cellular glutathione and ascorbate levels were nearly 30% and 50% lower, respectively, in cells from ALCAR-supplemented old rats than in untreated old rats, further indicating that ALCAR supplementation might increase oxidative stress. Ambulatory activity in young and old rats was quantified as a general measure of metabolic activity. Ambulatory activity, defined as mean total distance traveled, in old rats is almost 3-fold lower than in young animals. ALCAR supplementation increases ambulatory activity significantly in both young and old rats, with the increase being larger in old rats. Thus, ALCAR supplementation to old rats markedly reverses the age-associated decline in many indices of mitochondrial function and general metabolic activity, but may increase oxidative stress.

Effects of Taurine on Ozone-Induced Memory Deficits and Lipid Peroxidation Levels in Brains of Young, Mature, and Old Rats

2000 ◽  
Vol 82 (1) ◽  
pp. 7-17 ◽  
Author(s):  
Selva Rivas-Arancibia ◽  
Claudia Dorado-Martı́nez ◽  
Gabino Borgonio-Pérez ◽  
Marcia Hiriart-Urdanivia ◽  
Leticia Verdugo-Dı́az ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Memory Deficits ◽  
Old Rats

#111 Intraperitoneal lipopolysaccharide produces changes in brain metabolic activity as measured by [18F]FDG in the rat

2005 ◽  
Vol 19 (4) ◽  
pp. e57-e58
Author(s):  
Gregory H. Pelton ◽  
Leon N. Lyazidi ◽  
Raymond C. Chang ◽  
Davangere P. Devanand ◽  
Harold A. Sackheim ◽  
...  
Keyword(s):  
Metabolic Activity ◽  
18F Fdg ◽  
Brain Metabolic Activity

Resting Brain Metabolic Activity in Identical Twins Discordant for Combat Exposure

2008 ◽  
Author(s):  
Lisa Shin ◽  
Milad Mohammed ◽  
Natasha Lasko ◽  
Alan Fischman ◽  
Scott Rauch ◽  
...  
Keyword(s):  
Metabolic Activity ◽  
Combat Exposure ◽  
Identical Twins ◽  
Brain Metabolic Activity

The effects of hyperammonemia in learning and brain metabolic activity

2014 ◽  
Vol 29 (1) ◽  
pp. 113-120 ◽  
Author(s):  
Natalia Arias ◽  
Camino Fidalgo ◽  
Vicente Felipo ◽  
Jorge L. Arias
Keyword(s):  
Metabolic Activity ◽  
Brain Metabolic Activity

scholarly journals Dopamine D4 receptors modulate brain metabolic activity in the prefrontal cortex and cerebellum at rest and in response to methylphenidate

2010 ◽  
Vol 32 (4) ◽  
pp. 668-676 ◽  
Author(s):  
Michael Michaelides ◽  
Javier Pascau ◽  
Juan-Domingo Gispert ◽  
Foteini Delis ◽  
David K. Grandy ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Metabolic Activity ◽  
Brain Metabolic Activity

scholarly journals Sex differences in brain metabolic activity: Beyond the concept of brain age

2019 ◽  
Vol 116 (22) ◽  
pp. 10630-10631 ◽  
Author(s):  
Ewelina Biskup ◽  
Frances-Catherine Quevenco ◽  
Maria Teresa Ferretti ◽  
Antonella Santuccione-Chadha
Keyword(s):  
Sex Differences ◽  
Metabolic Activity ◽  
Brain Metabolic Activity ◽  
Brain Age
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