GAD2 gene sequence variations are associated with eating behaviors and weight gain in women from the Quebec family study

2009 ◽  
Vol 98 (4) ◽  
pp. 505-510 ◽  
Author(s):  
Anne C. Choquette ◽  
Simone Lemieux ◽  
Angelo Tremblay ◽  
Vicky Drapeau ◽  
Claude Bouchard ◽  
...  
Keyword(s):  
Weight Gain ◽  
Eating Behaviors ◽  
Gene Sequence ◽  
Family Study ◽  
Sequence Variations ◽  
Quebec Family Study

scholarly journals Familial Resemblance in Eating Behaviors in Men and Women from the Quebec Family Study

2005 ◽  
Vol 13 (9) ◽  
pp. 1624-1629 ◽  
Author(s):  
Véronique Provencher ◽  
Louis Pérusse ◽  
Luigi Bouchard ◽  
Vicky Drapeau ◽  
Claude Bouchard ◽  
...  
Keyword(s):  
Eating Behaviors ◽  
Family Study ◽  
Familial Resemblance ◽  
Men And Women ◽  
Quebec Family Study

scholarly journals A novel interaction between dietary composition and insulin secretion: effects on weight gain in the Quebec Family Study

2008 ◽  
Vol 87 (2) ◽  
pp. 303-309 ◽  
Author(s):  
Jean-Philippe Chaput ◽  
Angelo Tremblay ◽  
Eric B Rimm ◽  
Claude Bouchard ◽  
David S Ludwig
Keyword(s):  
Insulin Secretion ◽  
Weight Gain ◽  
Family Study ◽  
Dietary Composition ◽  
Quebec Family Study

scholarly journals Eating Behaviors and Indexes of Body Composition in Men and Women from the Québec Family Study

2003 ◽  
Vol 11 (6) ◽  
pp. 783-792 ◽  
Author(s):  
Véronique Provencher ◽  
Vicky Drapeau ◽  
Angelo Tremblay ◽  
Jean-Pierre Després ◽  
Simone Lemieux
Keyword(s):  
Body Composition ◽  
Eating Behaviors ◽  
Family Study ◽  
Men And Women ◽  
Quebec Family Study

scholarly journals Do 6-y changes in eating behaviors predict changes in body weight? Results from the Québec Family Study

2003 ◽  
Vol 27 (7) ◽  
pp. 808-814 ◽  
Author(s):  
V Drapeau ◽  
V Provencher ◽  
S Lemieux ◽  
J-P Després ◽  
C Bouchard ◽  
...  
Keyword(s):  
Body Weight ◽  
Eating Behaviors ◽  
Family Study ◽  
Quebec Family Study

scholarly journals The Association Between Sleep Duration and Weight Gain in Adults: A 6-Year Prospective Study from the Quebec Family Study

SLEEP ◽  
2008 ◽  
Vol 31 (4) ◽  
pp. 517-523 ◽  
Author(s):  
Jean-Philippe Chaput ◽  
Jean-Pierre Després ◽  
Claude Bouchard ◽  
Angelo Tremblay
Keyword(s):  
Weight Gain ◽  
Prospective Study ◽  
Sleep Duration ◽  
Family Study ◽  
Quebec Family Study

scholarly journals Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory

2021 ◽  
Author(s):  
Eric J. Brunner ◽  
Koutatsu Maruyama ◽  
Martin Shipley ◽  
Noriko Cable ◽  
Hiroyasu Iso ◽  
...  
Keyword(s):  
Weight Gain ◽  
Genetic Susceptibility ◽  
Eating Behaviors ◽  
Mixed Model ◽  
Adult Life ◽  
Cohort Effect ◽  
The Body ◽  
European Ancestry ◽  
Nucleotide Polymorphisms ◽  
Bmi Trajectories

Abstract Background/objectives The mediating role of eating behaviors in genetic susceptibility to weight gain during mid-adult life is not fully understood. This longitudinal study aims to help us understand contributions of genetic susceptibility and appetite to weight gain. Subjects/methods We followed the body-mass index (BMI) trajectories of 2464 adults from 45 to 65 years of age by measuring weight and height on four occasions at 5-year intervals. Genetic risk of obesity (gene risk score: GRS) was ascertained, comprising 92 BMI-associated single-nucleotide polymorphisms and split at a median (=high and low risk). At the baseline, the Eating Inventory was used to assess appetite-related traits of ‘disinhibition’, indicative of opportunistic eating or overeating and ‘hunger’ which is susceptibility to/ability to cope with the sensation of hunger. Roles of the GRS and two appetite-related scores for BMI trajectories were examined using a mixed model adjusted for the cohort effect and sex. Results Disinhibition was associated with higher BMI (β = 2.96; 95% CI: 2.66–3.25 kg/m2), and accounted for 34% of the genetically-linked BMI difference at age 45. Hunger was also associated with higher BMI (β = 1.20; 0.82–1.59 kg/m2) during mid-life and slightly steeper weight gain, but did not attenuate the effect of disinhibition. Conclusions Appetite disinhibition is most likely to be a defining characteristic of genetic susceptibility to obesity. High levels of appetite disinhibition, rather than hunger, may underlie genetic vulnerability to obesogenic environments in two-thirds of the population of European ancestry.

Engaging African American Adolescents and Stakeholders to Adapt Interpersonal Psychotherapy for Weight Gain Prevention

2017 ◽  
Vol 44 (2) ◽  
pp. 128-161 ◽  
Author(s):  
Omni Cassidy ◽  
Dawn M. Eichen ◽  
Natasha L. Burke ◽  
Jacqueline Patmore ◽  
Allison Shore ◽  
...  
Keyword(s):  
African American ◽  
Weight Gain ◽  
Interpersonal Relationships ◽  
Obesity Prevention ◽  
Eating Behaviors ◽  
Community Based Participatory Research ◽  
African American Adolescents ◽  
Total Sample ◽  
Interpersonal Psychotherapy ◽  
Obesity Prevention Programs

Developing culturally appropriate obesity prevention programs for African American (AA) adolescent girls that account for psychological risk factors is paramount to addressing health disparities. The current study was part of an investigation utilizing a community-based participatory research framework to gather qualitative data from urban AA girls, their caregivers, and community health liaisons to develop a novel obesity prevention program based on interpersonal psychotherapy for the prevention of excessive weight gain (IPT-WG). In the current study with urban AAs, data from seven focus groups (total sample size, N = 40) were analyzed using thematic analysis. Participants identified problematic eating behaviors, including binge or loss of control eating; highlighted the importance of interpersonal relationships, mood functioning, and eating; and supported the tenets of IPT-WG. While features of IPT-WG generally resonated with participants, culturally based modifications were suggested. These data will be used to inform the development of a culturally relevant IPT-WG program.

scholarly journals Nucleus accumbens cytoarchitecture predicts weight gain in children

2020 ◽  
Vol 117 (43) ◽  
pp. 26977-26984 ◽  
Author(s):  
Kristina M. Rapuano ◽  
Jennifer S. Laurent ◽  
Donald J. Hagler ◽  
Sean N. Hatton ◽  
Wesley K. Thompson ◽  
...  
Keyword(s):  
Weight Gain ◽  
Nucleus Accumbens ◽  
Waist Circumference ◽  
Eating Behaviors ◽  
Saturated Fat ◽  
Brain Regions ◽  
Cellular Density ◽  
Unhealthy Eating ◽  
Early Weight Gain ◽  
Prevalence Of Obesity

The prevalence of obesity in children and adolescents worldwide has quadrupled since 1975 and is a key predictor of obesity later in life. Previous work has consistently observed relationships between macroscale measures of reward-related brain regions (e.g., the nucleus accumbens [NAcc]) and unhealthy eating behaviors and outcomes; however, the mechanisms underlying these associations remain unclear. Recent work has highlighted a potential role of neuroinflammation in the NAcc in animal models of diet-induced obesity. Here, we leverage a diffusion MRI technique, restriction spectrum imaging, to probe the microstructure (cellular density) of subcortical brain regions. More specifically, we test the hypothesis that the cell density of reward-related regions is associated with obesity-related metrics and early weight gain. In a large cohort of nine- and ten-year-olds enrolled in the Adolescent Brain Cognitive Development (ABCD) study, we demonstrate that cellular density in the NAcc is related to individual differences in waist circumference at baseline and is predictive of increases in waist circumference after 1 y. These findings suggest a neurobiological mechanism for pediatric obesity consistent with rodent work showing that high saturated fat diets increase gliosis and neuroinflammation in reward-related brain regions, which in turn lead to further unhealthy eating and obesity.

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