Angiotensin converting enzyme inhibition lowers body weight and improves glucose tolerance in C57BL/6J mice maintained on a high fat diet

2009 ◽  
Vol 98 (1-2) ◽  
pp. 192-197 ◽  
Author(s):  
Richard S. Weisinger ◽  
Tracy K. Stanley ◽  
Denovan P. Begg ◽  
Harrison S. Weisinger ◽  
Kylie J. Spark ◽  
...  
Keyword(s):  
Body Weight ◽  
Glucose Tolerance ◽  
Angiotensin Converting Enzyme ◽  
Enzyme Inhibition ◽  
High Fat Diet ◽  
Angiotensin Converting Enzyme Inhibition ◽  
Converting Enzyme ◽  
High Fat ◽  
Converting Enzyme Inhibition

scholarly journals The Effect of Angiotensin-Converting Enzyme Inhibition Using Captopril on Energy Balance and Glucose Homeostasis

Endocrinology ◽  
2009 ◽  
Vol 150 (9) ◽  
pp. 4114-4123 ◽  
Author(s):  
Annette D. de Kloet ◽  
Eric G. Krause ◽  
Dong-Hoon Kim ◽  
Randall R. Sakai ◽  
Randy J. Seeley ◽  
...  
Keyword(s):  
Body Weight ◽  
Glucose Tolerance ◽  
Angiotensin Converting Enzyme ◽  
High Fat Diet ◽  
Renin Angiotensin System ◽  
Angiotensin Converting Enzyme Inhibition ◽  
Converting Enzyme ◽  
High Fat ◽  
Angiotensin System ◽  
Converting Enzyme Inhibition

Abstract Increasing evidence suggests that the renin-angiotensin-system contributes to the etiology of obesity. To evaluate the role of the renin-angiotensin-system in energy and glucose homeostasis, we examined body weight and composition, food intake, and glucose tolerance in rats given the angiotensin-converting enzyme inhibitor, captopril (∼40 mg/kg · d). Rats given captopril weighed less than controls when fed a high-fat diet (369.3 ± 8.0 vs. 441.7 ± 8.5 g after 35 d; P < 0.001) or low-fat chow (320.1 ± 4.9 vs. 339.8 ± 5.1 g after 21 d; P < 0.0001). This difference was attributable to reductions in adipose mass gained on high-fat (23.8 ± 2.0 vs. 65.12 ± 8.4 g after 35 d; P < 0.0001) and low-fat diets (12.2 ± 0.7 vs. 17.3 ± 1.3 g after 21 d; P < 0.001). Rats given captopril ate significantly less [3110.3 ± 57.8 vs. 3592.4 ± 88.8 kcal (cumulative 35 d high fat diet intake); P < 0.001] despite increased in neuropeptide-Y mRNA expression in the arcuate nucleus of the hypothalamus and had improved glucose tolerance compared with free-fed controls. Comparisons with pair-fed controls indicated that decreases in diet-induced weight gain and adiposity and improved glucose tolerance were due, primarily, to decreased food intake. To determine whether captopril caused animals to defend a lower body weight, animals in both groups were fasted for 24 h and subsequently restricted to 20% of their intake for 2 d. When free food was returned, captopril and control rats returned to their respective body weights and elicited comparable hyperphagic responses. These results suggest that angiotensin-converting enzyme inhibition protects against the development of diet-induced obesity and glucose intolerance.

Angiotensin converting enzyme inhibition from birth reduces body weight and body fat in Sprague–Dawley rats

2008 ◽  
Vol 93 (4-5) ◽  
pp. 820-825 ◽  
Author(s):  
Harrison S. Weisinger ◽  
Denovan P. Begg ◽  
Gary F. Egan ◽  
Anura P. Jayasooriya ◽  
Fanny Lie ◽  
...  
Keyword(s):  
Body Weight ◽  
Angiotensin Converting Enzyme ◽  
Enzyme Inhibition ◽  
Body Fat ◽  
Angiotensin Converting Enzyme Inhibition ◽  
Converting Enzyme ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Converting Enzyme Inhibition

Angiotensin-Converting Enzyme Inhibition and the Progression of Congestive Cardiomyopathy

Circulation ◽  
1995 ◽  
Vol 92 (3) ◽  
pp. 562-578 ◽  
Author(s):  
Francis G. Spinale ◽  
Henry H. Holzgrefe ◽  
Rupak Mukherjee ◽  
R. Barry Hird ◽  
Jennifer D. Walker ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Enzyme Inhibition ◽  
Angiotensin Converting Enzyme Inhibition ◽  
Converting Enzyme ◽  
Congestive Cardiomyopathy ◽  
Converting Enzyme Inhibition

Chronic Angiotensin-Converting Enzyme Inhibition and Endothelial Function of Rat Aorta

Hypertension ◽  
1995 ◽  
Vol 26 (5) ◽  
pp. 738-743 ◽  
Author(s):  
Guy Berkenboom ◽  
Dmitri Brékine ◽  
Philippe Unger ◽  
Katrina Grosfils ◽  
Michel Staroukine ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Endothelial Function ◽  
Enzyme Inhibition ◽  
Rat Aorta ◽  
Angiotensin Converting Enzyme Inhibition ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibition
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