A single exposure to social isolation in domestic piglets activates behavioural arousal, neuroendocrine stress hormones, and stress-related gene expression in the brain

2009 ◽  
Vol 98 (1-2) ◽  
pp. 176-185 ◽  
Author(s):  
E. Kanitz ◽  
B. Puppe ◽  
M. Tuchscherer ◽  
M. Heberer ◽  
T. Viergutz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Social Isolation ◽  
Stress Hormones ◽  
Related Gene ◽  
Single Exposure ◽  
The Brain

scholarly journals Acute social isolation alters neurogenomic state in songbird forebrain

2019 ◽  
Vol 117 (38) ◽  
pp. 23311-23316 ◽  
Author(s):  
Julia M. George ◽  
Zachary W. Bell ◽  
Daniel Condliffe ◽  
Kirstin Dohrer ◽  
Teresa Abaurrea ◽  
...  
Keyword(s):  
Gene Expression ◽  
Social Isolation ◽  
Axonal Guidance ◽  
Sequencing Analysis ◽  
Negative Effects ◽  
Auditory Forebrain ◽  
Gene Sets ◽  
Brain And Behavior ◽  
And Behavior ◽  
The Brain

Prolonged social isolation has negative effects on brain and behavior in humans and other social organisms, but neural mechanisms leading to these effects are not understood. Here we tested the hypothesis that even brief periods of social isolation can alter gene expression and DNA methylation in higher cognitive centers of the brain, focusing on the auditory/associative forebrain of the highly social zebra finch. Using RNA sequencing, we first identified genes that individually increase or decrease expression after isolation and observed general repression of gene sets annotated for neurotrophin pathways and axonal guidance functions. We then pursued 4 genes of large effect size: EGR1 and BDNF (decreased by isolation) and FKBP5 and UTS2B (increased). By in situ hybridization, each gene responded in different cell subsets, arguing against a single cellular mechanism. To test whether effects were specific to the social component of the isolation experience, we compared gene expression in birds isolated either alone or with a single familiar partner. Partner inclusion ameliorated the effect of solo isolation on EGR1 and BDNF, but not on FKBP5 and UTS2B nor on circulating corticosterone. By bisulfite sequencing analysis of auditory forebrain DNA, isolation caused changes in methylation of a subset of differentially expressed genes, including BDNF. Thus, social isolation has rapid consequences on gene activity in a higher integrative center of the brain, triggering epigenetic mechanisms that may influence processing of ongoing experience.

scholarly journals Mitochondria-Related Nuclear Gene Expression in the Nucleus Accumbens and Blood Mitochondrial Copy Number After Developmental Fentanyl Exposure in Adolescent Male and Female C57BL/6 Mice

2021 ◽  
Vol 12 ◽  
Author(s):  
Cali A. Calarco ◽  
Megan E. Fox ◽  
Saskia Van Terheyden ◽  
Makeda D. Turner ◽  
Jason B. Alipio ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nucleus Accumbens ◽  
Mitochondrial Function ◽  
Copy Number ◽  
Drug Exposure ◽  
Related Gene ◽  
Developmental Exposure ◽  
Neuronal Signaling ◽  
Mitochondrial Copy Number ◽  
The Brain

The potency of the synthetic opioid fentanyl and its increased clinical availability has led to the rapid escalation of use in the general population, increased recreational exposure, and subsequently opioid-related overdoses. The wide-spread use of fentanyl has, consequently, increased the incidence of in utero exposure to the drug, but the long-term effects of this type of developmental exposure are not yet understood. Opioid use has also been linked to reduced mitochondrial copy number in blood in clinical populations, but the link between this peripheral biomarker and genetic or functional changes in reward-related brain circuitry is still unclear. Additionally, mitochondrial-related gene expression in reward-related brain regions has not been examined in the context of fentanyl exposure, despite the growing literature demonstrating drugs of abuse impact mitochondrial function, which subsequently impacts neuronal signaling. The current study uses exposure to fentanyl via dam access to fentanyl drinking water during gestation and lactation as a model for developmental drug exposure. This perinatal drug-exposure is sufficient to impact mitochondrial copy number in circulating blood leukocytes, as well as mitochondrial-related gene expression in the nucleus accumbens (NAc), a reward-related brain structure, in a sex-dependent manner in adolescent offspring. Specific NAc gene expression is correlated with both blood mitochondrial copy number and with anxiety related behaviors dependent on developmental exposure to fentanyl and sex. These data indicate that developmental fentanyl exposure impacts mitochondrial function in both the brain and body in ways that can impact neuronal signaling and may prime the brain for altered reward-related behavior in adolescence and later into adulthood.

scholarly journals Glycosylation-related gene expression profiling in the brain and spleen of scrapie-affected mouse

Glycobiology ◽  
2009 ◽  
Vol 19 (8) ◽  
pp. 879-889 ◽  
Author(s):  
F. Guillerme-Bosselut ◽  
L. Forestier ◽  
C. Jayat-Vignoles ◽  
J.-L. Vilotte ◽  
I. Popa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Related Gene ◽  
Affected Mouse ◽  
The Brain

Chemokine-related gene expression in the brain following ischemic stroke: No role for CXCR2 in outcome

2011 ◽  
Vol 1372 ◽  
pp. 169-179 ◽  
Author(s):  
Vanessa H. Brait ◽  
Jennifer Rivera ◽  
Brad R.S. Broughton ◽  
Seyoung Lee ◽  
Grant R. Drummond ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ischemic Stroke ◽  
Related Gene ◽  
The Brain

scholarly journals Post-weaning social isolation alters anxiety-related behavior and neurochemical gene expression in the brain of male prairie voles

2009 ◽  
Vol 454 (1) ◽  
pp. 67-71 ◽  
Author(s):  
Yongliang Pan ◽  
Yan Liu ◽  
Kimberly A. Young ◽  
Zhibin Zhang ◽  
Zuoxin Wang
Keyword(s):  
Gene Expression ◽  
Social Isolation ◽  
Prairie Voles ◽  
The Brain

Gene expression in the brain of rats with increased aggression and signs of cognitive deficits caused by the early social isolation

2017 ◽  
Vol 27 ◽  
pp. S587-S588
Author(s):  
N.A. Krupina ◽  
E.A. Zubkov ◽  
Y.A. Zorkina ◽  
E.V. Orshanskaya ◽  
N.N. Khlebnikova
Keyword(s):  
Gene Expression ◽  
Social Isolation ◽  
Cognitive Deficits ◽  
The Brain

scholarly journals Social Isolation and Group Size are Associated with Divergent Gene Expression in the Brain of Ant Queens

2021 ◽  
Author(s):  
Fabio Manfredini ◽  
Carlos Martinez‐Ruiz ◽  
Yannick Wurm ◽  
De Wayne Shoemaker ◽  
Mark J. F. Brown
Keyword(s):  
Gene Expression ◽  
Social Isolation ◽  
Group Size ◽  
Divergent Gene ◽  
The Brain
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