Chronic social stress in the visible burrow system modulates stress-related gene expression in the bed nucleus of the stria terminalis

2006 ◽  
Vol 89 (3) ◽  
pp. 301-310 ◽  
Author(s):  
D CHOI ◽  
M NGUYEN ◽  
K TAMASHIRO ◽  
L MA ◽  
R SAKAI ◽  
...  
Keyword(s):  
Gene Expression ◽  
Social Stress ◽  
Stria Terminalis ◽  
Related Gene ◽  
Burrow System ◽  
Bed Nucleus ◽  
Chronic Social Stress

scholarly journals Microarray analysis reveals distinctive signaling between the bed nucleus of the stria terminalis, nucleus accumbens, and dorsal striatum

2008 ◽  
Vol 32 (3) ◽  
pp. 283-298 ◽  
Author(s):  
Christopher M. Olsen ◽  
Yong Huang ◽  
Shirlean Goodwin ◽  
Daniel C. Ciobanu ◽  
Lu Lu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Synaptic Plasticity ◽  
Nucleus Accumbens ◽  
Signaling Pathways ◽  
Microarray Analysis ◽  
Dorsal Striatum ◽  
Brain Regions ◽  
Stria Terminalis ◽  
Bed Nucleus ◽  
Insight Into

To identify distinct transcriptional patterns between the major subcortical dopamine targets commonly studied in addiction we studied differences in gene expression between the bed nucleus of the stria terminalis (BNST), nucleus accumbens (NAc), and dorsal striatum (dStr) using microarray analysis. We first tested for differences in expression of genes encoding transcripts for common neurotransmitter systems as well as calcium binding proteins routinely used in neuroanatomical delineation of brain regions. This a priori method revealed differential expression of corticotropin releasing hormone ( Crh), the GABA transporter ( Slc6a1), and prodynorphin ( Pdyn) mRNAs as well as several others. Using a gene ontology tool, functional scoring analysis, and Ingenuity Pathway Analysis, we further identified several physiological pathways that were distinct among these brain regions. These two different analyses both identified calcium signaling, G-coupled protein receptor signaling, and adenylate cyclase-related signaling as significantly different among the BNST, NAc, and dStr. These types of signaling pathways play important roles in, amongst other things, synaptic plasticity. Investigation of differential gene expression revealed several instances that may provide insight into reported differences in synaptic plasticity between these brain regions. The results support other studies suggesting that crucial pathways involved in neurotransmission are distinct among the BNST, NAc, and dStr and provide insight into the potential use of pharmacological agents that may target region-specific signaling pathways. Furthermore, these studies provide a framework for future mouse-mouse comparisons of transcriptional profiles after behavioral/pharmacological manipulation.

scholarly journals Role of CRF receptor 1 antagonism in the bed nucleus of the stria terminalis of male rats after intermittent social defeat stress

2019 ◽  
Author(s):  
Mailton Vasconcelos ◽  
Dirson J. Stein ◽  
Matheus Gallas-Lopes ◽  
Luane Landau ◽  
Luiza Behrens ◽  
...  
Keyword(s):  
Social Behavior ◽  
Social Stress ◽  
Social Behaviors ◽  
Social Defeat ◽  
Corticotropin Releasing Factor ◽  
Male Rats ◽  
Stria Terminalis ◽  
Social Avoidance ◽  
Bed Nucleus ◽  
Sweet Solution

AbstractWe recently demonstrated that the experience of brief episodes of social defeat caused impairments in social behaviors. Moreover, we provided evidence that the antagonism of corticotropin-releasing factor binding protein (CRFBP) in the bed nucleus of the stria terminalis (BNST) restored social approach in stressed animals. This study aimed to test the relation between corticotropin-releasing factor receptor type 1 (CRFR1) located in the BNST and the establishment of social stress-disrupted behaviors in rats submitted to social defeat in the resident-intruder paradigm. Animals were tested for sweet solution preference, subjected to the elevated-plus maze (EPM), and to the social interaction three-chamber test. Social behavior was tested after BNST drug infusions. The drug used in this study was a CRF receptor 1 antagonist, CP376395 (CP), administered in two doses: 50 ng/0.20 μL/side, and 500 ng/0.20 μL/side. Saline solution was used as vehicle and administered 0.20 μL/side. Socially stressed animals (n = 11) did not differ compared to control animals (n = 11) in the EPM. Stressed animals displayed impaired social behavior, represented by a decrease in time spent in the interaction zone. The lower dose (CP 50 ng/0.20 μL/side) administered intra-BNST restored social behaviors in stressed animals. On the other hand, the higher dose of the CRFR1 antagonist (CP 500 ng/0.20 μL/side) induced social avoidance in rats without a history of agonistic confrontations. These findings implicate BNST CRFR1 signaling in the modulation of social behaviors in rats given the choice to explore an unfamiliar conspecific.

scholarly journals CRE/CREB-Driven Up-Regulation of Gene Expression by Chronic Social Stress in CRE-Luciferase Transgenic Mice: Reversal by Antidepressant Treatment

PLoS ONE ◽  
2007 ◽  
Vol 2 (5) ◽  
pp. e431 ◽  
Author(s):  
Ulrike Böer ◽  
Tahseen Alejel ◽  
Stephan Beimesche ◽  
Irmgard Cierny ◽  
Doris Krause ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transgenic Mice ◽  
Social Stress ◽  
Antidepressant Treatment ◽  
Regulation Of Gene Expression ◽  
Chronic Social Stress

Visible burrow system as a model of chronic social stress: Behavioral and neuroendocrine correlates

1995 ◽  
Vol 20 (2) ◽  
pp. 117-134 ◽  
Author(s):  
D.Caroline Blanchard ◽  
Robert L. Spencer ◽  
Scott M. Weiss ◽  
Robert J. Blanchard ◽  
Bruce McEwen ◽  
...  
Keyword(s):  
Social Stress ◽  
Burrow System ◽  
Chronic Social Stress
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