scholarly journals Exact probability distribution function for the volatility of cumulative production

2018 ◽  
Vol 495 ◽  
pp. 59-66
Author(s):  
Rubina Zadourian ◽  
Andreas Klümper
Keyword(s):  
Distribution Function ◽  
Probability Distribution ◽  
Probability Distribution Function ◽  
Exact Probability ◽  
Exact Probability Distribution ◽  
Cumulative Production

scholarly journals Blinking statistics and molecular counting in direct stochastic reconstruction microscopy (dSTORM)

2021 ◽  
Author(s):  
Lekha Patel ◽  
David Williamson ◽  
Dylan M Owen ◽  
Edward A K Cohen
Keyword(s):  
Probability Distribution ◽  
Single Molecule ◽  
Immunological Synapse ◽  
Training Data ◽  
Supplementary Information ◽  
Cellular Structures ◽  
Exact Probability ◽  
Stochastic Optical Reconstruction Microscopy ◽  
Exact Probability Distribution ◽  
Optical Reconstruction

Abstract Motivation Many recent advancements in single-molecule localization microscopy exploit the stochastic photoswitching of fluorophores to reveal complex cellular structures beyond the classical diffraction limit. However, this same stochasticity makes counting the number of molecules to high precision extremely challenging, preventing key insight into the cellular structures and processes under observation. Results Modelling the photoswitching behaviour of a fluorophore as an unobserved continuous time Markov process transitioning between a single fluorescent and multiple dark states, and fully mitigating for missed blinks and false positives, we present a method for computing the exact probability distribution for the number of observed localizations from a single photoswitching fluorophore. This is then extended to provide the probability distribution for the number of localizations in a direct stochastic optical reconstruction microscopy experiment involving an arbitrary number of molecules. We demonstrate that when training data are available to estimate photoswitching rates, the unknown number of molecules can be accurately recovered from the posterior mode of the number of molecules given the number of localizations. Finally, we demonstrate the method on experimental data by quantifying the number of adapter protein linker for activation of T cells on the cell surface of the T-cell immunological synapse. Availability and implementation Software and data available at https://github.com/lp1611/mol_count_dstorm. Supplementary information Supplementary data are available at Bioinformatics online.

scholarly journals On the birthday problem: some generalizations and applications

2003 ◽  
Vol 2003 (60) ◽  
pp. 3827-3840 ◽  
Author(s):  
P. N. Rathie ◽  
P. Zörnig
Keyword(s):  
Probability Distribution ◽  
Random Graph ◽  
Generating Functions ◽  
Hypergeometric Functions ◽  
Exact Probability ◽  
Confluent Hypergeometric Functions ◽  
Birthday Problem ◽  
Exact Probability Distribution

We study the birthday problem and some possible extensions. We discuss the unimodality of the corresponding exact probability distribution and express the moments and generating functions by means of confluent hypergeometric functionsU(−;−;−)which are computable using the software Mathematica. The distribution is generalized in two possible directions, one of them consists in considering a random graph with a single attracting center. Possible applications are also indicated.

scholarly journals An Online Application for ΔR Calculation

Radiocarbon ◽  
2016 ◽  
Vol 59 (5) ◽  
pp. 1623-1627 ◽  
Author(s):  
Ron W Reimer ◽  
Paula J Reimer
Keyword(s):  
Distribution Function ◽  
Probability Distribution ◽  
Calibration Curve ◽  
Probability Distribution Function ◽  
Museum Collections ◽  
Online Program ◽  
Online Application ◽  
Radiocarbon Calibration

AbstractA regional offset (ΔR) from the marine radiocarbon calibration curve is widely used in calibration software (e.g. CALIB, OxCal) but often is not calculated correctly. While relatively straightforward for known-age samples, such as mollusks from museum collections or annually banded corals, it is more difficult to calculate ΔR and the uncertainty in ΔR for 14C dates on paired marine and terrestrial samples. Previous researchers have often utilized classical intercept methods that do not account for the full calibrated probability distribution function (pdf). Recently, Soulet (2015) provided R code for calculating reservoir ages using the pdfs, but did not address ΔR and the uncertainty in ΔR. We have developed an online application for performing these calculations for known-age, paired marine and terrestrial 14C dates and U-Th dated corals. This article briefly discusses methods that have been used for calculating ΔR and the uncertainty and describes the online program deltar, which is available free of charge.

scholarly journals Optimal Taylor–Couette turbulence

2012 ◽  
Vol 706 ◽  
pp. 118-149 ◽  
Author(s):  
Dennis P. M. van Gils ◽  
Sander G. Huisman ◽  
Siegfried Grossmann ◽  
Chao Sun ◽  
Detlef Lohse
Keyword(s):  
Distribution Function ◽  
Probability Distribution ◽  
Angular Velocity ◽  
Probability Distribution Function ◽  
Neutral Line ◽  
Velocity Ratio ◽  
Outer Cylinder ◽  
Taylor Number ◽  
Counter Rotation ◽  
Taylor Couette

AbstractStrongly turbulent Taylor–Couette flow with independently rotating inner and outer cylinders with a radius ratio of $\eta = 0. 716$ is experimentally studied. From global torque measurements, we analyse the dimensionless angular velocity flux ${\mathit{Nu}}_{\omega } (\mathit{Ta}, a)$ as a function of the Taylor number $\mathit{Ta}$ and the angular velocity ratio $a= \ensuremath{-} {\omega }_{o} / {\omega }_{i} $ in the large-Taylor-number regime $1{0}^{11} \lesssim \mathit{Ta}\lesssim 1{0}^{13} $ and well off the inviscid stability borders (Rayleigh lines) $a= \ensuremath{-} {\eta }^{2} $ for co-rotation and $a= \infty $ for counter-rotation. We analyse the data with the common power-law ansatz for the dimensionless angular velocity transport flux ${\mathit{Nu}}_{\omega } (\mathit{Ta}, a)= f(a)\hspace{0.167em} {\mathit{Ta}}^{\gamma } $, with an amplitude $f(a)$ and an exponent $\gamma $. The data are consistent with one effective exponent $\gamma = 0. 39\pm 0. 03$ for all $a$, but we discuss a possible $a$ dependence in the co- and weakly counter-rotating regimes. The amplitude of the angular velocity flux $f(a)\equiv {\mathit{Nu}}_{\omega } (\mathit{Ta}, a)/ {\mathit{Ta}}^{0. 39} $ is measured to be maximal at slight counter-rotation, namely at an angular velocity ratio of ${a}_{\mathit{opt}} = 0. 33\pm 0. 04$, i.e. along the line ${\omega }_{o} = \ensuremath{-} 0. 33{\omega }_{i} $. This value is theoretically interpreted as the result of a competition between the destabilizing inner cylinder rotation and the stabilizing but shear-enhancing outer cylinder counter-rotation. With the help of laser Doppler anemometry, we provide angular velocity profiles and in particular identify the radial position ${r}_{n} $ of the neutral line, defined by $ \mathop{ \langle \omega ({r}_{n} )\rangle } \nolimits _{t} = 0$ for fixed height $z$. For these large $\mathit{Ta}$ values, the ratio $a\approx 0. 40$, which is close to ${a}_{\mathit{opt}} = 0. 33$, is distinguished by a zero angular velocity gradient $\partial \omega / \partial r= 0$ in the bulk. While for moderate counter-rotation $\ensuremath{-} 0. 40{\omega }_{i} \lesssim {\omega }_{o} \lt 0$, the neutral line still remains close to the outer cylinder and the probability distribution function of the bulk angular velocity is observed to be monomodal. For stronger counter-rotation the neutral line is pushed inwards towards the inner cylinder; in this regime the probability distribution function of the bulk angular velocity becomes bimodal, reflecting intermittent bursts of turbulent structures beyond the neutral line into the outer flow domain, which otherwise is stabilized by the counter-rotating outer cylinder. Finally, a hypothesis is offered allowing a unifying view and consistent interpretation for all these various results.

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