A bi-stable neuronal model of Gibbs distribution

2015 ◽  
Vol 429 ◽  
pp. 118-124
Author(s):  
Eitan Gross
Keyword(s):  
Neuronal Model ◽  
Gibbs Distribution

An Unifying Neuronal Model for Normal and Abnormal Thinking

2016 ◽  
Author(s):  
Daniele Quintella Mendes ◽  
Luís Alfredo V. Carvalho ◽  
Roseli S. Wedemann
Keyword(s):  
Neuronal Model

scholarly journals High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chialin Cheng ◽  
Surya A. Reis ◽  
Emily T. Adams ◽  
Daniel M. Fass ◽  
Steven P. Angus ◽  
...  
Keyword(s):  
High Throughput Screening ◽  
Neural Progenitor Cells ◽  
Kinase Inhibitors ◽  
Ex Vivo ◽  
Clinical Investigation ◽  
Neuronal Model ◽  
Tau Phosphorylation ◽  
Neuronal Cultures ◽  
Proteomic Profiling ◽  
Induced Pluripotent

AbstractMutations in MAPT (microtubule-associated protein tau) cause frontotemporal dementia (FTD). MAPT mutations are associated with abnormal tau phosphorylation levels and accumulation of misfolded tau protein that can propagate between neurons ultimately leading to cell death (tauopathy). Recently, a p.A152T tau variant was identified as a risk factor for FTD, Alzheimer's disease, and synucleinopathies. Here we used induced pluripotent stem cells (iPSC) from a patient carrying this p.A152T variant to create a robust, functional cellular assay system for probing pathophysiological tau accumulation and phosphorylation. Using stably transduced iPSC-derived neural progenitor cells engineered to enable inducible expression of the pro-neural transcription factor Neurogenin 2 (Ngn2), we generated disease-relevant, cortical-like glutamatergic neurons in a scalable, high-throughput screening compatible format. Utilizing automated confocal microscopy, and an advanced image-processing pipeline optimized for analysis of morphologically complex human neuronal cultures, we report quantitative, subcellular localization-specific effects of multiple kinase inhibitors on tau, including ones under clinical investigation not previously reported to affect tau phosphorylation. These results demonstrate the potential for using patient iPSC-derived ex vivo models of tauopathy as genetically accurate, disease-relevant systems to probe tau biochemistry and support the discovery of novel therapeutics for tauopathies.

scholarly journals Emergence of chimera states in a neuronal model of delayed oscillators

2021 ◽  
Vol 3 (3) ◽  
Author(s):  
Alessandra Lucchetti ◽  
Mogens H. Jensen ◽  
Mathias L. Heltberg
Keyword(s):  
Neuronal Model ◽  
Chimera States

scholarly journals Coagulation Processes with Gibbsian Time Evolution

2012 ◽  
Vol 49 (03) ◽  
pp. 612-626
Author(s):  
Boris L. Granovsky ◽  
Alexander V. Kryvoshaev
Keyword(s):  
Stochastic Process ◽  
Recurrence Relation ◽  
Time Evolution ◽  
Nonnegative Function ◽  
Gibbs Distribution ◽  
Time Dependent ◽  
Explicit Solutions ◽  
Gibbs Distributions ◽  
Giant Cluster ◽  
Positive Integers

We prove that a stochastic process of pure coagulation has at any timet≥ 0 a time-dependent Gibbs distribution if and only if the rates ψ(i,j) of single coagulations are of the form ψ(i;j) =if(j) +jf(i), wherefis an arbitrary nonnegative function on the set of positive integers. We also obtain a recurrence relation for weights of these Gibbs distributions that allow us to derive the general form of the solution and the explicit solutions in three particular cases of the functionf. For the three corresponding models, we study the probability of coagulation into one giant cluster by timet> 0.

A Neuronal Model of a Global Workspace in Effortful Cognitive Tasks

2006 ◽  
Vol 929 (1) ◽  
pp. 152-165 ◽  
Author(s):  
STANISLAS DEHAENE ◽  
MICHEL KERSZBERG ◽  
JEAN-PIERRE CHANGEUX
Keyword(s):  
Neuronal Model ◽  
Cognitive Tasks ◽  
Global Workspace

Pathophysiology of dystonia: A neuronal model

2002 ◽  
Vol 17 (S3) ◽  
pp. S49-S62 ◽  
Author(s):  
Jerrold L. Vitek
Keyword(s):  
Neuronal Model
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