Finite size scaling of the spontaneous symmetry breaking model of X-chromosome inactivation

2009 ◽  
Vol 388 (6) ◽  
pp. 843-850 ◽  
Author(s):  
D. Barker ◽  
A. Griffiths
Keyword(s):  
Symmetry Breaking ◽  
Spontaneous Symmetry Breaking ◽  
X Chromosome ◽  
Finite Size ◽  
X Chromosome Inactivation ◽  
Chromosome Inactivation ◽  
Finite Size Scaling ◽  
Size Scaling

Symmetry breaking and finite size scaling in antiferromagnets

1993 ◽  
Vol 3 (2) ◽  
pp. 291-298 ◽  
Author(s):  
P. Azaria ◽  
B. Delamotte ◽  
D. Mouhanna
Keyword(s):  
Symmetry Breaking ◽  
Finite Size ◽  
Finite Size Scaling ◽  
Size Scaling

scholarly journals Mean-Field Theory of the Symmetry Breaking Model for X Chromosome Inactivation

2011 ◽  
Vol 191 ◽  
pp. 40-45 ◽  
Author(s):  
Antonio Scialdone ◽  
Mariano Barbieri ◽  
Deborah Pallotti ◽  
Mario Nicodemi
Keyword(s):  
Field Theory ◽  
Symmetry Breaking ◽  
X Chromosome ◽  
Mean Field Theory ◽  
Mean Field ◽  
X Chromosome Inactivation ◽  
Chromosome Inactivation

scholarly journals Entanglement gap, corners, and symmetry breaking

2021 ◽  
Vol 10 (3) ◽  
Author(s):  
Vincenzo Alba
Keyword(s):  
Symmetry Breaking ◽  
Critical Point ◽  
Magnetic Order ◽  
Finite Size ◽  
Spherical Model ◽  
Low Energy ◽  
Two Dimensional ◽  
Finite Size Scaling ◽  
Size Scaling ◽  
Energy Part

We investigate the finite-size scaling of the lowest entanglement gap \delta\xiδξ in the ordered phase of the two-dimensional quantum spherical model (QSM). The entanglement gap decays as \delta\xi=\Omega/\sqrt{L\ln(L)}δξ=Ω/Lln(L). This is in contrast with the purely logarithmic behaviour as \delta\xi=\pi^2/\ln(L)δξ=π2/ln(L) at the critical point. The faster decay in the ordered phase reflects the presence of magnetic order. We analytically determine the constant \OmegaΩ, which depends on the low-energy part of the model dispersion and on the geometry of the bipartition. In particular, we are able to compute the corner contribution to \OmegaΩ, at least for the case of a square corner.

X-linked CNV and skewed X-chromosome inactivation

2020 ◽  
pp. 19-21
Author(s):  
Е.А. Фонова ◽  
Е.Н. Толмачева ◽  
А.А. Кашеварова ◽  
М.Е. Лопаткина ◽  
К.А. Павлова ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Intellectual Disability ◽  
X Chromosome ◽  
Copy Number ◽  
Copy Number Variations ◽  
X Chromosome Inactivation ◽  
Chromosome Inactivation ◽  
Chromosome X ◽  
Skewed X Chromosome Inactivation

Смещение инактивации Х-хромосомы может быть следствием и маркером нарушения клеточной пролиферации при вариациях числа копий ДНК на Х-хромосоме. Х-сцепленные CNV выявляются как у женщин с невынашиванием беременности и смещением инактивации Х-хромосомы (с частотой 33,3%), так и у пациентов с умственной отсталостью и смещением инактивацией у их матерей (с частотой 40%). A skewed X-chromosome inactivation can be a consequence and a marker of impaired cell proliferation in the presence of copy number variations (CNV) on the X chromosome. X-linked CNVs are detected in women with miscarriages and a skewed X-chromosome inactivation (with a frequency of 33.3%), as well as in patients with intellectual disability and skewed X-chromosome inactivation in their mothers (with a frequency of 40%).

scholarly journals X-Linked Emery–Dreifuss Muscular Dystrophy: Study Of X-Chromosome Inactivation and Its Relation with Clinical Phenotypes in Female Carriers

Genes ◽  
2019 ◽  
Vol 10 (11) ◽  
pp. 919 ◽  
Author(s):  
Viggiano ◽  
Madej-Pilarczyk ◽  
Carboni ◽  
Picillo ◽  
Ergoli ◽  
...  
Keyword(s):  
Muscular Dystrophy ◽  
X Chromosome ◽  
Clinical Symptoms ◽  
Fibrous Tissue ◽  
X Chromosome Inactivation ◽  
Chromosome Inactivation ◽  
Cardiac Conduction ◽  
Asymptomatic Carriers ◽  
Cardiac Symptoms ◽  
Female Carriers

X-linked Emery–Dreifuss muscular dystrophy (EDMD1) affects approximately 1:100,000 male births. Female carriers are usually asymptomatic but, in some cases, they may present clinical symptoms after age 50 at cardiac level, especially in the form of conduction tissue anomalies. The aim of this study was to evaluate the relation between heart involvement in symptomatic EDMD1 carriers and the X-chromosome inactivation (XCI) pattern. The XCI pattern was determined on the lymphocytes of 30 symptomatic and asymptomatic EDMD1 female carriers—25 familial and 5 sporadic cases—seeking genetic advice using the androgen receptor (AR) methylation-based assay. Carriers were subdivided according to whether they were above or below 50 years of age. A variance analysis was performed to compare the XCI pattern between symptomatic and asymptomatic carriers. The results show that 20% of EDMD1 carriers had cardiac symptoms, and that 50% of these were ≥50 years of age. The XCI pattern was similar in both symptomatic and asymptomatic carriers. Conclusions: Arrhythmias in EDMD1 carriers poorly correlate on lymphocytes to a skewed XCI, probably due to (a) the different embryological origin of cardiac conduction tissue compared to lymphocytes or (b) the preferential loss of atrial cells replaced by fibrous tissue.

scholarly journals Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects

Cell Reports ◽  
2019 ◽  
Vol 27 (2) ◽  
pp. 442-454.e5 ◽  
Author(s):  
Alex R.D. Delbridge ◽  
Andrew J. Kueh ◽  
Francine Ke ◽  
Natasha M. Zamudio ◽  
Farrah El-Saafin ◽  
...  
Keyword(s):  
X Chromosome ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
X Chromosome Inactivation ◽  
Chromosome Inactivation ◽  
Female Specific
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