Computational fluid dynamics tools can be used to predict the progression of coronary artery disease

2006 ◽  
Vol 362 (1) ◽  
pp. 182-190 ◽  
Author(s):  
A. Ümit Coşkun ◽  
Caixia Chen ◽  
Peter H. Stone ◽  
Charles L. Feldman
Keyword(s):  
Fluid Dynamics ◽  
Coronary Artery Disease ◽  
Computational Fluid Dynamics ◽  
Coronary Artery ◽  
Artery Disease

scholarly journals Functional assessment of coronary artery disease by intravascular ultrasound and computational fluid dynamics simulation

2014 ◽  
Vol 33 (10) ◽  
pp. 645.e1-645.e4 ◽  
Author(s):  
Sebastián Carrizo ◽  
Xinzhou Xie ◽  
Rafael Peinado-Peinado ◽  
Angel Sánchez-Recalde ◽  
Santiago Jiménez-Valero ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Coronary Artery Disease ◽  
Computational Fluid Dynamics ◽  
Coronary Artery ◽  
Intravascular Ultrasound ◽  
Functional Assessment ◽  
Dynamics Simulation ◽  
Computational Fluid Dynamics Simulation ◽  
Artery Disease

scholarly journals Fractional Flow Reserve Derived from Coronary Imaging and Computational Fluid Dynamics

2014 ◽  
Vol 9 (3) ◽  
pp. 145 ◽  
Author(s):  
Ioannis Pantos ◽  
Demosthenes Katritsis ◽  
◽  
Keyword(s):  
Fluid Dynamics ◽  
Coronary Artery Disease ◽  
Computational Fluid Dynamics ◽  
Coronary Artery ◽  
Fractional Flow Reserve ◽  
Fractional Flow ◽  
Artery Cannulation ◽  
Flow Reserve ◽  
Artery Disease

The assessment of functional severity of atherosclerotic stenoses in patients with coronary artery disease by invasive fractional flow reserve (FFR) measurement requires coronary artery cannulation, advancement of a wire and intravenous adenosine infusion with inherent procedure-related risk and costs. Coronary computed tomographic angiography (CCTA) and rotational coronary angiography (RA) have been recently used in conjunction with computational fluid dynamics (CFD) and image-based modelling for the determination of FFR without the need for additional imaging, modification of acquisition protocols or administration of medication. FFR derived from CCTA was demonstrated as superior to measures of CCTA stenosis severity for determination of lesion-specific ischaemia. Estimation of FFR from RA images and CFD provides a less invasive alternative to conventional FFR measurement while estimated values are in agreement with measured values. These new, combined anatomic–functional assessments have the potential to simplify the noninvasive diagnosis of coronary artery disease with a single study to identify patients with ischaemia-causing stenosis who may benefit from revascularisation.

scholarly journals Evaluation of functional severity of coronary artery disease and fluid dynamics' influence on hemodynamic parameters: A review

2013 ◽  
Vol 29 (3) ◽  
pp. 225-232 ◽  
Author(s):  
Kalimuthu Govindaraju ◽  
Irfan Anjum Badruddin ◽  
Girish N. Viswanathan ◽  
S.V. Ramesh ◽  
A. Badarudin
Keyword(s):  
Fluid Dynamics ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Hemodynamic Parameters ◽  
Artery Disease

Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease

2019 ◽  
Vol 133 (22) ◽  
pp. 2283-2299
Author(s):  
Apabrita Ayan Das ◽  
Devasmita Chakravarty ◽  
Debmalya Bhunia ◽  
Surajit Ghosh ◽  
Prakash C. Mandal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Chronic Inflammation ◽  
Ex Vivo ◽  
Human Subjects ◽  
Critical Role ◽  
Atherosclerotic Cardiovascular Disease ◽  
Tnf Α ◽  
Artery Disease

Abstract The role of inflammation in all phases of atherosclerotic process is well established and soluble TREM-like transcript 1 (sTLT1) is reported to be associated with chronic inflammation. Yet, no information is available about the involvement of sTLT1 in atherosclerotic cardiovascular disease. Present study was undertaken to determine the pathophysiological significance of sTLT1 in atherosclerosis by employing an observational study on human subjects (n=117) followed by experiments in human macrophages and atherosclerotic apolipoprotein E (apoE)−/− mice. Plasma level of sTLT1 was found to be significantly (P<0.05) higher in clinical (2342 ± 184 pg/ml) and subclinical cases (1773 ± 118 pg/ml) than healthy controls (461 ± 57 pg/ml). Moreover, statistical analyses further indicated that sTLT1 was not only associated with common risk factors for Coronary Artery Disease (CAD) in both clinical and subclinical groups but also strongly correlated with disease severity. Ex vivo studies on macrophages showed that sTLT1 interacts with Fcɣ receptor I (FcɣRI) to activate spleen tyrosine kinase (SYK)-mediated downstream MAP kinase signalling cascade to activate nuclear factor-κ B (NF-kB). Activation of NF-kB induces secretion of tumour necrosis factor-α (TNF-α) from macrophage cells that plays pivotal role in governing the persistence of chronic inflammation. Atherosclerotic apoE−/− mice also showed high levels of sTLT1 and TNF-α in nearly occluded aortic stage indicating the contribution of sTLT1 in inflammation. Our results clearly demonstrate that sTLT1 is clinically related to the risk factors of CAD. We also showed that binding of sTLT1 with macrophage membrane receptor, FcɣR1 initiates inflammatory signals in macrophages suggesting its critical role in thrombus development and atherosclerosis.

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