Melaleuca quinquenervia essential oil inhibits α-melanocyte-stimulating hormone-induced melanin production and oxidative stress in B16 melanoma cells

Phytomedicine ◽  
2017 ◽  
Vol 34 ◽  
pp. 191-201 ◽  
Author(s):  
Wen-Wan Chao ◽  
Chia-Chi Su ◽  
Hsin-Yi Peng ◽  
Su-Tze Chou
Keyword(s):  
Oxidative Stress ◽  
Essential Oil ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
Melaleuca Quinquenervia ◽  
Melanin Production ◽  
Melanocyte Stimulating Hormone ◽  
B16 Melanoma Cells ◽  
And Oxidative Stress ◽  
Stimulating Hormone

Torilin fromTorilis japonicaInhibits Melanin Production in α-Melanocyte Stimulating Hormone-Activated B16 Melanoma Cells

Planta Medica ◽  
2009 ◽  
Vol 75 (14) ◽  
pp. 1505-1508 ◽  
Author(s):  
Cheong-Yong Yun ◽  
Dongchun Kim ◽  
Won-Hee Lee ◽  
Yu Park ◽  
Seung Lee ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
B16 Melanoma ◽  
Melanin Production ◽  
Melanocyte Stimulating Hormone ◽  
B16 Melanoma Cells ◽  
Stimulating Hormone

scholarly journals Effect of Phlorotannins Isolated From Eisenia bicyclis on Melanogenesis in Mouse B16 Melanoma Cells

2021 ◽  
Vol 16 (5) ◽  
pp. 1934578X2110192
Author(s):  
Yuki Ohno ◽  
Shiori Kondo ◽  
Kiho Tajima ◽  
Toshiyuki Shibata ◽  
Tomohiro Itoh
Keyword(s):  
Melanoma Cells ◽  
B16 Melanoma ◽  
Physiological Effects ◽  
Related Protein ◽  
Eisenia Bicyclis ◽  
Melanin Production ◽  
Melanocyte Stimulating Hormone ◽  
B16 Melanoma Cells ◽  
Anti Cancer ◽  
Tyrosinase Related Protein

Phlorotannins isolated from brown algae, such as Eisena bicyclis, have positive physiological effects, including anti-cancer, anti-inflammatory, and anti-Alzheimer’s disease. Although phlorotannins have been shown to inhibit tyrosinase, an enzyme essential for melanogenesis, their effect on melanogenesis remains unexplored. Thus, we isolated phlorotannins from E. bicyclis and examined their effects on α-melanocyte-stimulating hormone (α-MSH)-induced melanogenesis in murine B16 melanoma cells. Both fucofuroeckol-A (FF-A) and phlorofucofuroeckol-A (PFF-A) suppressed α-MSH-induced melanogenesis. Neither inhibited human tyrosinase (TYR) activity, but both inhibited tyrosinase-related protein-2 activity. FF-A downregulated the expression of microphthalmia-associated transcription factor and TYR, which subsequently suppressed melanin production. These results suggest that phlorotannins could be beneficial as melanin control drugs for hyperpigmentation disorders.

scholarly journals Resveratrol Inhibits Alpha-Melanocyte-Stimulating Hormone Signaling, Viability, and Invasiveness in Melanoma Cells

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Yu-Jen Chen ◽  
Ying-Yin Chen ◽  
Yi-Feng Lin ◽  
Hsuan-Yun Hu ◽  
Hui-Fen Liao
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Nuclear Translocation ◽  
Combined Treatment ◽  
Treatment Resistance ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
Melanocyte Stimulating Hormone ◽  
B16 Melanoma Cells ◽  
Stimulating Hormone

Melanoma is a malignancy with high potential to invasion and treatment resistance. Theα-melanocyte-stimulating hormone (α-MSH) signal transduction involving Wnt/β-catenin, c-Kit, and microphthalmia-associated transcription factor (MITF), a known pathway to produce melanin, has been demonstrated as one of cancer stem cell characteristics. This study was aimed to examine the effect of resveratrol, an abundant ingredient of grape and medicinal plants, onα-MSH signaling, viability, and invasiveness in melanoma cells. Byα-MSH treatment, the melanin production in B16 melanoma cells was augmented as a validation for activation ofα-MSH signaling. The upregulated expression ofα-MSH signaling-related moleculesβ-catenin, c-Kit, and MITF was suppressed by resveratrol and/or STI571 treatment. Nuclear translocation of MITF, a hallmark ofα-MSH signaling activation, was inhibited by combined treatment of resveratrol and STI571. At effective concentration, resveratrol and/or STI571 inhibited cell viability andα-MSH-activated matrix metalloproteinase- (MMP-)9 expression and invasion capacity of B16 melanoma cells. In conclusion, resveratrol enhances STI571 effect on suppressing theα-MSH signaling, viability, and invasiveness in melanoma cells. It implicates that resveratrol may have potential to modulate the cancer stem cell characteristics of melanoma.

Investigation of the Regulation of Pigmentation in α-Melanocyte-Stimulating Hormone Responsive and Unresponsive Cultured B16 Melanoma Cells

1989 ◽  
Vol 2 (3) ◽  
pp. 161-166 ◽  
Author(s):  
SARAH E. HILL ◽  
JAYNE BUFFEY ◽  
ANTHONY J. THODY ◽  
IAN OLIVER ◽  
STANLEY S. BLEEHEN ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
B16 Melanoma ◽  
Melanocyte Stimulating Hormone ◽  
B16 Melanoma Cells ◽  
Stimulating Hormone
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