Clivorine, an otonecine pyrrolizidine alkaloid from Ligularia species, impairs neuronal differentiation via NGF-induced signaling pathway in cultured PC12 cells

Phytomedicine ◽  
2016 ◽  
Vol 23 (9) ◽  
pp. 931-938 ◽  
Author(s):  
Aizhen Xiong ◽  
Artemis Lu Yan ◽  
Cathy W.C. Bi ◽  
Kelly Y.C. Lam ◽  
Gallant K.L. Chan ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Neuronal Differentiation ◽  
Pc12 Cells ◽  
Pyrrolizidine Alkaloid

Metabolites of sesamin, a major lignan in sesame seeds, induce neuronal differentiation in PC12 cells through activation of ERK1/2 signaling pathway

2009 ◽  
Vol 116 (7) ◽  
pp. 841-852 ◽  
Author(s):  
Nanako Hamada ◽  
Yasunori Fujita ◽  
Arisa Tanaka ◽  
Makoto Naoi ◽  
Yoshinori Nozawa ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Neuronal Differentiation ◽  
Pc12 Cells ◽  
Sesame Seeds

scholarly journals Sciatic nerve leachate of cattle causes neuronal differentiation of PC12 cells via ERK1/2 signaling pathway

2018 ◽  
Vol 19 (4) ◽  
pp. 512 ◽  
Author(s):  
Ziqiang Zhang ◽  
Yumei Liu ◽  
Xuemin Zhu ◽  
Lan Wei ◽  
Jiamin Zhu ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Signaling Pathway ◽  
Neuronal Differentiation ◽  
Pc12 Cells

scholarly journals Identification ofCentella asiatica’s Effective Ingredients for Inducing the Neuronal Differentiation

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Hui Jiang ◽  
Guoshuai Zheng ◽  
Junwei Lv ◽  
Heyu Chen ◽  
Jinjin Lin ◽  
...  
Keyword(s):  
Pilot Study ◽  
Neurodegenerative Diseases ◽  
Signaling Pathway ◽  
Neuronal Differentiation ◽  
Pc12 Cells ◽  
Centella Asiatica ◽  
Mek Inhibitor ◽  
Asiatic Acid ◽  
Fingerprint Analysis

Centella asiatica, commonly known as Gotu kola, has been widely used as a traditional herb for decades. Yet, the study on which compounds or compound combinations actually lead to its brain benefits remains scarce. To study the neuroprotection effects ofCentella asiatica, neuronal differentiation of PC12 cells was applied. In our pilot study, we isolated 45Centella asiaticafractions and tested their abilities for inducing neuronal differentiation on PC12 cells. The most effective fraction showed robust induction in neurite outgrowth and neurofilament expression. LC-MS fingerprint analysis of this fraction revealed asiatic acid and madecassic acid as the dominant components. A further investigation on the pure combination of these two compounds indicated that the combination of these two compounds extensively promoted nerve differentiationin vitro. Application of PD98059, a protein MEK inhibitor, attenuated combination-induced neurofilament expression, indicating the combination-induced nerve differentiation through activation of MEK signaling pathway. Our results support the use of combination of asiatic acid and madecassic acid as an effective mean to intervene neurodegenerative diseases in which neurotrophin deficiency is involved.

Irisin Ameliorates Hypoxia/Reoxygenation-Induced Inflammation and Apoptosis in PC12 Cells by Inhibiting TLR4/MYD88 Signaling Pathway

2019 ◽  
Vol 17 (3) ◽  
pp. 329-336
Author(s):  
Wang Jinli ◽  
Xu Fenfen ◽  
Zheng Yuan ◽  
Cheng Xu ◽  
Zhang Piaopiao ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Signaling Pathway ◽  
Pc12 Cells ◽  
Major Complication ◽  
Lactic Dehydrogenase ◽  
Dependent Manner ◽  
Cerebral Ischemic Stroke ◽  
Cerebral Ischemic ◽  
Myd88 Signaling ◽  
Hypoxia Reoxygenation

Cardiovascular disease including cerebral ischemic stroke is the major complication that increases the morbidity and mortality in patients with diabetes mellitus as much as four times. It has been well established that irisin, with its ability to regulate glucose and lipid homeostasis as well as anti-inflammatory and anti-apoptotic properties, has been widely examined for its therapeutic potentials in managing metabolic disorders. However, the mechanism of irisin in the regulation of cerebral ischemic stroke remains unclear. Using PC12 cells as a model, we have shown that hypoxia/reoxygenation inhibits cell viability and increases lactic dehydrogenase. Irisin, in a dose-dependent manner, reversed these changes. The increase in inflammatory mediators (IL-1β, IL-6, and TNF-α) by hypoxia/reoxygenation was reversed by irisin. Furthermore, the cell apoptosis promoted by hypoxia/reoxygenation was also inhibited by irisin. Irisin suppressed TLR4/MyD88 signaling pathway leading to amelioration of inflammation and apoptosis in PC12 cells. Thus, inhibition of TLR4/MyD88 signaling pathway via irisin could be an important mechanism in the regulation of hypoxia/reoxygenation-induced inflammation and apoptosis in PC12 cells.

Neuroprotective effect of NDEELNK from sea cucumber ovum against scopolamine-induced PC12 cells damage through enhancing energy metabolism and upregulation of PKA/BDNF/NGF signaling pathway

2021 ◽  
Author(s):  
Yue Zhao ◽  
Yifei Dong ◽  
Qi Ge ◽  
Pengbo Cui ◽  
Na Sun ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Signaling Pathway ◽  
Pc12 Cells ◽  
Sea Cucumber ◽  
Molecular Mechanisms ◽  
Neuroprotective Effect ◽  
Ngf Signaling ◽  
Neuroprotective Function

The aim of study was to evaluate the neuroprotective function of sea cucumber ovum peptides-derived NDEELNK and explore underlying molecular mechanisms. NDEELNK exerted neuroprotective effect by improving the acetylcholine (ACh)...

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