Valeriana wallichii root extract improves sleep quality and modulates brain monoamine level in rats

Phytomedicine ◽  
2012 ◽  
Vol 19 (10) ◽  
pp. 924-929 ◽  
Author(s):  
Surajit Sahu ◽  
Koushik Ray ◽  
M.S. Yogendra Kumar ◽  
Shilpa Gupta ◽  
Hina Kauser ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Root Extract ◽  
Monoamine Level ◽  
Brain Monoamine

scholarly journals Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Kumarpillai Gopukumar ◽  
Shefali Thanawala ◽  
Venkateswarlu Somepalli ◽  
T. S. Sathyanaryana Rao ◽  
Vijaya Bhaskar Thamatam ◽  
...  
Keyword(s):  
Placebo Group ◽  
Clinical Study ◽  
Sleep Quality ◽  
Cognitive Functions ◽  
Serum Cortisol ◽  
Well Being ◽  
Root Extract ◽  
Double Blind ◽  
Psychological Well Being ◽  
Stress Levels

Background. The global prevalence of stress is increasing. Stress adversely affects cognitive ability, sleep quality, and overall psychological well-being. Ashwagandha (Withania somnifera (L.) Dunal), an essential medicine in Ayurveda, is reportedly beneficial in reducing stress and improving memory. This double-blind, randomized, placebo-controlled clinical study evaluated the effect of Ashwagandha root extract sustained-release capsule 300 mg (Prolanza™; hereafter Ashwagandha SR) on cognitive functions, stress levels, sleep quality, overall well-being, and safety in stressed subjects. Methods. Subjects (130 healthy cognitively sound adults [20–55 years, body mass index:18–29 kg/m2]) having a Perceived Stress Scale (PSS) score of 14–24 were randomized to receive either Ashwagandha SR or placebo. Subjects took one capsule of Ashwagandha SR or placebo daily for 90 consecutive days. This study was registered on Clinical Trials Registry-India (CTRI) on 13/11/2019 [number: CTRI/2019/11/021990]. The primary endpoint was the change in cognitive function as measured by CANTAB from baseline to the end of the study period (90 ± 7 days). The secondary outcomes included the change in PSS-10 score, serum cortisol level (9–11 am), the OHQ score, the PSQI, and serum BDNF levels. Results. Only 125 completed the study and were evaluated. The Cambridge Neuropsychological Test Automated Battery (CANTAB) reported significantly improved recall memory, and the total error rate in recalling patterns significantly decreased at visit 4 in the Ashwagandha SR group vs. the placebo group (first attempt memory score:12.9 ± 6.7 vs. 10.1 ± 6.3; total errors:17.5 ± 23.3 vs. 27.7 ± 23.6). At visit 4, lower PSS-10 score (13.0 ± 5.0 vs. 18.7 ± 4.6; p < .0001 ), serum cortisol levels p = 0.0443 , and Pittsburgh Sleep Quality Index (PSQI) score p < .0001 but higher Oxford Happiness Questionnaire (OHQ) scores p < .0001 were seen in Ashwagandha SR vs. the placebo group, suggesting significantly lower stress levels and significantly better psychological well-being and sleep quality in the former. No adverse events were reported. Conclusions. This is the first clinical study assessing Ashwagandha SR for its safety and efficacy. Treatment with one Ashwagandha SR capsule once daily for 90 days improved memory and focus, psychological well-being, and sleep quality, reduced stress levels, and was safe and well-tolerated.

The effects of Berberis vulgaris L. root extract on the opiate withdrawal syndrome and psychological factors: a randomized double-blind clinical trial

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Fatemeh Dabaghzadeh ◽  
Fariba Sharififar ◽  
Amir-Mohammad Ahmadzadeh ◽  
Somayyeh Karami-Mohajeri
Keyword(s):  
Clinical Trial ◽  
Placebo Group ◽  
Sleep Quality ◽  
Withdrawal Syndrome ◽  
Methadone Maintenance ◽  
Signs And Symptoms ◽  
Opiate Withdrawal ◽  
Root Extract ◽  
Berberis Vulgaris ◽  
Opiate Withdrawal Syndrome

Abstract Objectives In this clinical trial, the effect of aqueous extract of Berberis vulgaris L. was investigated on opiate withdrawal syndrome, depression, anxiety, stress, and sleep quality in opioid addicts which were under methadone maintenance therapy. Methods For this purpose, 52 opiate addicts were randomly selected of whom 28 received 500 mg capsules of B. vulgaris extract (treatment) and the rest received 500 mg of starch capsules (placebo), twice daily for 4 weeks. Signs and symptoms of opiate withdrawal syndrome, depression, anxiety, stress, and sleep quality were assessed through Clinical Opiate Withdrawal Scale (COWS), Pittsburgh Sleep Quality Inventory (PSQI) and Depression Anxiety Stress Scales-21 (DASS-21) questionnaires at baseline and after 7, 14, and 28 days of receiving intervention. Results Signs and symptoms of opiate withdrawal syndrome were significantly improved in those who received the extract for 1 month compared to the placebo group. However, there were no significant differences in depression, anxiety, stress, and sleep quality scores in the treatment group compared to those in the placebo group. Conclusions The extract of B. vulgaris root as a traditional herbal product in combination with methadone could improve the symptoms and signs of opiate withdrawal.

P.0028 Prenatal alcohol affects anxiety and the rat brain monoamine level in a sexually-dimorphic manner

2021 ◽  
Vol 53 ◽  
pp. S21-S22
Author(s):  
S. Kopylova ◽  
A. Veretinskaya ◽  
P. Anokhin ◽  
N. Sarycheva ◽  
I. Shamakina
Keyword(s):  
Rat Brain ◽  
Sexually Dimorphic ◽  
Monoamine Level ◽  
Prenatal Alcohol ◽  
Brain Monoamine

scholarly journals A Comparative Study on the Effects of Nicotine and GTS-21, a New Nicotinic Agonist, on the Locomotor Activity and Brain Monoamine Level

1998 ◽  
Vol 78 (3) ◽  
pp. 385-390 ◽  
Author(s):  
toasato Nanri ◽  
Nobuo Kasahara ◽  
Jyunji Yamamoto ◽  
Hidekazu Miyake ◽  
Hiroshi Watanabe
Keyword(s):  
Locomotor Activity ◽  
Comparative Study ◽  
Monoamine Level ◽  
Brain Monoamine ◽  
Nicotinic Agonist

Schlafqualität und deren Beziehung zu attentional-exekutiven Funktionsleistungen bei unipolar depressiven Patienten

2016 ◽  
Vol 27 (4) ◽  
pp. 231-243 ◽  
Author(s):  
Bernd Kundermann ◽  
Stanislava Fockenberg ◽  
Nicole Cabanel ◽  
Matthias J. Müller
Keyword(s):  
Sleep Quality ◽  
Trail Making Test ◽  
Trail Making

Zusammenfassung. Die Beziehung zwischen kognitiven Defiziten und Schlafstörungen depressiver Patienten wurde bisher wenig untersucht. Stationär behandelte depressive Patienten beantworteten Fragebögen zur Depressivität und Schlafqualität (Pittsburgh Sleep Quality Inventory, PSQI), gefolgt von neuropsychologischen Untersuchungen zu attentional-exekutiven Funktionsleistungen (Trail Making Test: TMT-A, TMT-B) an Tag 1 (abends) und Tag 2 (morgens). Patienten mit schweren Schlafstörungen (PSQI > 10, n = 8) erbrachten gegenüber Patienten mit maximal moderat ausgeprägten Schlafstörungen (PSQI ≤ 10, n = 8) signifikant geringere Leistungen im Rahmen des TMT-A und TMT-B. Signifikante positive Korrelationen zwischen dem Globalwert des PSQI und der TMT-B-Bearbeitungszeit blieben auch unter statistischer Berücksichtigung von Kovariaten erhalten. Diese Ergebnisse unterstreichen die enge Beziehung zwischen kognitiven Dysfunktionen und Schlafstörungen bei depressiven Patienten. Mögliche therapeutische Implikationen werden diskutiert.

Inhibition of Rat Brain Monoamine Oxidase Activities by Psoralen and Isopsoralen: Implications for the Treatment of Affective Disorders

2001 ◽  
Vol 88 (2) ◽  
pp. 75-80 ◽  
Author(s):  
Ling Dong Kong ◽  
Ren Xiang Tan ◽  
Anthony Yiu Ho Woo ◽  
Christopher Hon Ki Cheng2Note
Keyword(s):  
Monoamine Oxidase ◽  
Rat Brain ◽  
Affective Disorders ◽  
Brain Monoamine

Early adolescent drinking and cannabis use predicts later sleep-quality problems.

2019 ◽  
Vol 33 (3) ◽  
pp. 266-273 ◽  
Author(s):  
Rowan P. Ogeil ◽  
Ali Cheetham ◽  
Anna Mooney ◽  
Nicholas B. Allen ◽  
Orli Schwartz ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Cannabis Use ◽  
Early Adolescent ◽  
Adolescent Drinking

Rumination Is Associated With Angry and Depressed Mood and Sleep Quality

2003 ◽  
Author(s):  
D. K. Thomsen ◽  
M. Y. Mehlsen ◽  
S. Christensen ◽  
R. Zachariae
Keyword(s):  
Sleep Quality ◽  
Depressed Mood
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