α-Santalol, a derivative of sandalwood oil, induces apoptosis in human prostate cancer cells by causing caspase-3 activation

Phytomedicine ◽  
2012 ◽  
Vol 19 (8-9) ◽  
pp. 804-811 ◽  
Author(s):  
Ajay Bommareddy ◽  
Brittny Rule ◽  
Adam L. VanWert ◽  
Sreevidya Santha ◽  
Chandradhar Dwivedi
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Caspase 3 ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Sandalwood Oil

scholarly journals Inhibition of Prostate Cancer Cell Growth by Human Secreted PDZ Domain-Containing Protein 2, a Potential Autocrine Prostate Tumor Suppressor

Endocrinology ◽  
2006 ◽  
Vol 147 (11) ◽  
pp. 5023-5033 ◽  
Author(s):  
C. W. Tam ◽  
A. S. Cheng ◽  
R. Y. M. Ma ◽  
K.-M. Yao ◽  
S. Y. W. Shiu
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Caspase 3 ◽  
Pdz Domain ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Lncap Cells ◽  
Prostate Cancer Cells ◽  
Autocrine Growth ◽  
Endogenous Expression

A possible role of the PDZ domain-containing protein 2 (PDZD2) in prostate tumorigenesis has been suggested. Besides, PDZD2 is posttranslationally cleaved by a caspase-dependent mechanism to form a secreted PDZ domain-containing protein 2 (sPDZD2) with unknown functions in humans. In this study, we demonstrate the endogenous expression of PDZD2 and secretion of sPDZD2 in cancerous DU145, PC-3, 22Rv1, LNCaP, and immortalized RWPE-1 prostate epithelial cells. Inhibition of endogenous sPDZD2 production and secretion by DU145, PC-3, 22Rv1, and RWPE-1 cells via the caspase-3 inhibitor Z-DEVD-FMK resulted in increased cell proliferation, which was abrogated by treatment with exogenous recombinant sPDZD2. Whereas sPDZD2-induced antiproliferation in DU145, PC-3, and 22Rv1 cells, it induced apoptosis in LNCaP cells. The data suggest that endogenous sPDZD2, produced by caspase-3-mediated cleavage from PDZD2, may function as a novel autocrine growth suppressor for human prostate cancer cells. The antiproliferative effect of sPDZD2 was apparently mediated through slowing the entry of DU145, PC-3, and 22Rv1 cells into the S phase of the cell cycle. In DU145 cells, this can be attributed to stimulated p53 and p21CIP1/WAF1 expression by sPDZD2. On the other hand, the apoptotic effect of sPDZD2 on LNCaP cells was apparently mediated via p53-independent Bad stimulation. Together our results indicate the presence of p53-dependent and p53-independent PDZD2/sPDZD2 autocrine growth suppressive signaling pathways in human prostate cancer cells and suggest a novel therapeutic approach of harnessing the latent tumor-suppressive potential of an endogenous autocrine signaling protein like sPDZD2 to inhibit prostate cancer growth.

Osteoblast-derived factors increased metastatic potential in human prostate cancer cells

2016 ◽  
Author(s):  
Terese Karlsson ◽  
Reshma Sundar ◽  
Anders Widmark ◽  
Marene Landstrom ◽  
Emma Persson
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Metastatic Potential ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

Anticancer Activity of Methyl Gallate in RC-58T/h/SA#4 Primary Human Prostate Cancer Cells

2014 ◽  
Vol 43 (3) ◽  
pp. 367-373 ◽  
Author(s):  
Soon Jae Kwon ◽  
Ju Hye Lee ◽  
Jae Yong Kim ◽  
Kwang Deog Moon ◽  
Sung Tae Yee ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Methyl Gallate ◽  
Prostate Cancer Cells
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