Viscum album inhibits cell growth, migration and invasion of pediatric tumor cell lines – But effects are limited at concentrations found in serum

Phytomedicine ◽  
2011 ◽  
Vol 18 ◽  
pp. S8-S9
Author(s):  
T.J. Zuzak ◽  
M. Bornschein ◽  
K. Menke ◽  
H. Stephan ◽  
K. Pajtler ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Cell Lines ◽  
Viscum Album ◽  
Migration And Invasion ◽  
Tumor Cell Lines ◽  
Pediatric Tumor

Preclinical investigation of interaction of mistletoe extract (Viscum album L.) with radio- and chemotherapy in pediatric tumor cell lines

Phytomedicine ◽  
2019 ◽  
Vol 61 ◽  
pp. 4
Author(s):  
Katrin Menke ◽  
Melanie Schwermer ◽  
Katharina Falke ◽  
Jürgen Eisenbraun ◽  
Alexander Schramm ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Viscum Album ◽  
Tumor Cell Lines ◽  
Pediatric Tumor ◽  
Mistletoe Extract ◽  
Preclinical Investigation

Preclinical Evaluation of Antitumoral and Cytotoxic Properties of Viscum album Fraxini Extract on Pediatric Tumor Cells

Planta Medica ◽  
2019 ◽  
Vol 85 (14/15) ◽  
pp. 1150-1159 ◽  
Author(s):  
Katrin Menke ◽  
Melanie Schwermer ◽  
Alexander Schramm ◽  
Tycho J. Zuzak
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Neuroblastoma Cell ◽  
Migration And Invasion ◽  
Tumor Cell Lines ◽  
Pediatric Tumor ◽  
Mistletoe Extract ◽  
Mitochondrial Integrity ◽  
Neuroblastoma Cell Lines

AbstractIn Europe, especially in German-speaking countries, administration of mistletoe extracts is the most common and popular complementary and alternative therapy approach reported in oncology. Mistletoe therapy is applied to children with cancer for curative and palliative therapeutic regimes with increasing frequency, but at the same time, there are only a few studies on the effectiveness of this therapy. Therefore, we have investigated the response of various pediatric cell lines (acute myeloid leukemia, Ewingʼs sarcoma, hepatocellular carcinoma, medulloblastoma, neuroblastoma, and osteosarcoma) to mistletoe extract, abnobaVISCUM Fraxini. Effects on cell proliferation, cell cycle distribution as well as on mitochondrial integrity and caspase-mediated apoptosis were investigated in neuroblastoma cell lines, SH-SY5Y and Kelly. Additionally, in vitro tumor cell migration and invasion were studied. In vivo effects of the mistletoe extract were investigated in a syngeneic neuroblastoma mouse model. We could show that tumor cell lines were from 5- to 640-fold more sensitive to abnobaVISCUM Fraxini treatment than non-tumorigenic fibroblasts, whereby neuroblastoma cell lines were the most sensitive. For two neuroblastoma cell lines, SH-SY5Y and Kelly, induction of caspase-9-mediated apoptosis, a decrease of mitochondrial integrity as well as attenuation of migration and invasion were observed. In vivo experiments revealed a reduction of tumor growth and a prolonged survival of tumor-bearing animals. In summary, we can state that these results provide the first preclinical data for cytotoxic activities of abnobaVISCUM Fraxini for a broad panel of pediatric tumor cell lines, in particular, neuroblastoma cells. Thus, it might be a potential remedy for the supportive treatment of neuroblastoma.

scholarly journals A Nuclear-Directed Ribonuclease Variant Targets Cancer Stem Cells and Inhibits Migration and Invasion of Breast Cancer Cells

Cancers ◽  
2021 ◽  
Vol 13 (17) ◽  
pp. 4350
Author(s):  
Jessica Castro ◽  
Giusy Tornillo ◽  
Gerardo Ceada ◽  
Beatriz Ramos-Neble ◽  
Marlon Bravo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Tumor Cell ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Cell Lines ◽  
Breast Cancer Cells ◽  
Migration And Invasion ◽  
Tumor Cell Lines

Despite the significant advances in cancer research made in recent years, this disease remains one of the leading causes of death worldwide. In part, this is due to the fact that after therapy, a subpopulation of self-renewing tumor cells can survive and promote cancer relapse, resistance to therapies and metastasis. Targeting these cancer stem cells (CSCs) is therefore essential to improve the clinical outcome of cancer patients. In this sense, multi-targeted drugs may be promising agents targeting CSC-associated multifocal effects. We have previously constructed different human pancreatic ribonuclease (RNase) variants that are cytotoxic for tumor cells due to a non-classical nuclear localization signal introduced in their sequence. These cytotoxic RNases affect the expression of multiple genes involved in deregulated metabolic and signaling pathways in cancer cells and are highly cytotoxic for multidrug-resistant tumor cell lines. Here, we show that these cytotoxic nuclear-directed RNases are highly selective for tumor cell lines grown in 3D, inhibit CSCs’ development and diminish the self-renewal capacity of the CSCs population. Moreover, these human RNase variants reduce the migration and invasiveness of highly invasive breast cancer cells and downregulate N-cadherin expression.

Primitive neuroectodermal tumor cell lines derived from a metastatic pediatric tumor

1994 ◽  
Vol 30 (12) ◽  
pp. 813-816 ◽  
Author(s):  
Miho Furue ◽  
Tetsuji Okamoto ◽  
Masakazu Ikeda ◽  
Yukichi Tanaka ◽  
Yoshirou Sasaki ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Primitive Neuroectodermal Tumor ◽  
Neuroectodermal Tumor ◽  
Tumor Cell Lines ◽  
Pediatric Tumor

Hsp90 inhibition by NVP-AUY922 and NVP-BEP800 decreases migration and invasion of irradiated normoxic and hypoxic tumor cell lines

2013 ◽  
Vol 331 (2) ◽  
pp. 200-210 ◽  
Author(s):  
Susanne Hartmann ◽  
Nadine Günther ◽  
Marlene Biehl ◽  
Astrid Katzer ◽  
Sebastian Kuger ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Migration And Invasion ◽  
Tumor Cell Lines ◽  
Hsp90 Inhibition ◽  
Hypoxic Tumor

Evaluation of Effect of Triterpenes and Limonoids on Cell Growth, Cell Cycle and Apoptosis in Human Tumor Cell Lines

2010 ◽  
Vol 10 (10) ◽  
pp. 769-776 ◽  
Author(s):  
Cristiane M. Cazal ◽  
Kantima Choosang ◽  
Vanessa Gisele P. Severino ◽  
Marcio S. Soares ◽  
Andre Lucio F. Sarria ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Tumor Cell ◽  
Cell Lines ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines
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