Bioactive components from the tea polyphenols influence on endogenous antioxidant defense system and modulate inflammatory cytokines after total-body irradiation in mice

Phytomedicine ◽  
2011 ◽  
Vol 18 (11) ◽  
pp. 970-975 ◽  
Author(s):  
Yuan Hu ◽  
Dai-Hong Guo ◽  
Ping Liu ◽  
Jing-Jing Cao ◽  
Ya-Ping Wang ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Total Body Irradiation ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Tea Polyphenols ◽  
Bioactive Components ◽  
Defense System ◽  
Total Body ◽  
Endogenous Antioxidant

Skeletal muscle uncoupling-induced longevity in mice is linked to increased substrate metabolism and induction of the endogenous antioxidant defense system

2013 ◽  
Vol 304 (5) ◽  
pp. E495-E506 ◽  
Author(s):  
S. Keipert ◽  
M. Ost ◽  
A. Chadt ◽  
A. Voigt ◽  
V. Ayala ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Mapk Signaling ◽  
Redox Signaling ◽  
Defense System ◽  
High Fat ◽  
Substrate Metabolism ◽  
Endogenous Antioxidant

Ectopic expression of uncoupling protein 1 (UCP1) in skeletal muscle (SM) mitochondria increases lifespan considerably in high-fat diet-fed UCP1 Tg mice compared with wild types (WT). To clarify the underlying mechanisms, we investigated substrate metabolism as well as oxidative stress damage and antioxidant defense in SM of low-fat- and high-fat-fed mice. Tg mice showed an increased protein expression of phosphorylated AMP-activated protein kinase, markers of lipid turnover (p-ACC, FAT/CD36), and an increased SM ex vivo fatty acid oxidation. Surprisingly, UCP1 Tg mice showed elevated lipid peroxidative protein modifications with no changes in glycoxidation or direct protein oxidation. This was paralleled by an induction of catalase and superoxide dismutase activity, an increased redox signaling (MAPK signaling pathway), and increased expression of stress-protective heat shock protein 25. We conclude that increased skeletal muscle mitochondrial uncoupling in vivo does not reduce the oxidative stress status in the muscle cell. Moreover, it increases lipid metabolism and reactive lipid-derived carbonyls. This stress induction in turn increases the endogenous antioxidant defense system and redox signaling. Altogether, our data argue for an adaptive role of reactive species as essential signaling molecules for health and longevity.

Potential neuroprotection of wheat alkylresorcinols in hippocampal neurons via Nrf2/ARE pathway

2020 ◽  
Vol 11 (11) ◽  
pp. 10161-10169
Author(s):  
Fengjiao Fan ◽  
Yanyu Zou ◽  
Yong Fang ◽  
Peng Li ◽  
Ji Xia ◽  
...  
Keyword(s):  
Hippocampal Neurons ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Defense System ◽  
System P ◽  
Endogenous Antioxidant

Neuroprotection of Wheat Alkylresorcinols by Modulating Endogenous Antioxidant Defense System.

scholarly journals Effect of Extract and Ellagic Acid from Geranium schiedeanum on the Antioxidant Defense System in An Induced-Necrosis Model

Antioxidants ◽  
2018 ◽  
Vol 7 (12) ◽  
pp. 178 ◽  
Author(s):  
Nancy Vargas-Mendoza ◽  
Miguel Vázquez-Velasco ◽  
Laura González-Torres ◽  
Juana Benedí ◽  
Francisco Sánchez-Muniz ◽  
...  
Keyword(s):  
Liver Injury ◽  
Ellagic Acid ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Sublethal Dose ◽  
Defense System ◽  
Active Metabolites ◽  
Total Extract ◽  
Traditional Therapies ◽  
Endogenous Antioxidant

Geranium schiedeanum has been used in traditional therapies as an antiseptic, antipyretic, and as analgesic. The present study was designed to evaluate the pretreatment with G. schiedeanum total extract (GS) and its active metabolites on stimulating the endogenous antioxidant defense system (EADS): catalase (Cat), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione reduction index (RI GSH/GSSG) in rat liver treated with a sublethal dose (6.6 mmol/Kg) of thioacetamide (TAA) in order to probe the capacity of GS and the active compounds to reduce liver injury. This was assessed by measuring aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin (BILT) in rats pretreated or not with TAA, and pretreated or not with GS and its metabolites. The results showed that GS was able to induce the production of EADS enzymes, increasing redox index GSH/GSSG at 24 and 48 h after intoxication, and both the extract and the ellagic acid exhibited a significant reduction of hepatic damage markers. Our data confirmed the hepatoprotective effect of GS and its metabolites, like ellagic acid, support the possible use of this extract in the treatment of liver injury.

scholarly journals Protective effect of honokiol against LPS-induced lung injury via attenuation of matrix metalloproteinase-9 and oxidative stress

2016 ◽  
Vol 68 (4) ◽  
pp. 877-881 ◽  
Author(s):  
Hong-Bo Li ◽  
Lin Wang ◽  
Zheng-Tao Gu ◽  
Xuan He ◽  
Lei Su
Keyword(s):  
Oxidative Stress ◽  
Lung Injury ◽  
Matrix Metalloproteinase ◽  
Protective Effect ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Matrix Metalloproteinase 9 ◽  
Defense System ◽  
Endogenous Antioxidant ◽  
Metalloproteinase 9

Despite high morbidity and mortality, no effective options are available for the treatment of acute lung injury (ALI). Therefore, the present study investigated the protective effect of honokiol (HK) on ALI via determination of its effect on several key biomarkers. The results of the study showed that HK significantly inhibited the infiltration of neutrophils and protein leakage induced by lipopolysaccharide (LPS) (p<0.05). The pretreatment with HK considerably boosted the endogenous antioxidant defense system to counteract the oxidative stress in LPS-induced ALI by elevating the levels of superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH). Moreover, the activity of toxic mediators, such as myeloperoxidase (MPO), and lipid peroxidation were significantly inhibited upon treatment with HK. In order to examine the mechanism of action of HK, its effect was quantified using matrix metalloproteinase-9 (MMP-9) activity in bronchoalveolar lavage fluid (BALF) by gelatin zymography. Pretreatment with HK considerably suppressed the activation of MMP-9 in a concentration-dependent manner. These findings suggest that HK protects from lung injury via inhibition of MMP-9, and by enhancing the activity of the endogenous antioxidant defense system.

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