Risk of infections during the first year of life after in utero exposure to drugs acting on immunity: A population-based cohort study

2016 ◽  
Vol 113 ◽  
pp. 557-562 ◽  
Author(s):  
Lucie Palosse-Cantaloube ◽  
Caroline Hurault-Delarue ◽  
Anna-Belle Beau ◽  
Jean-Louis Montastruc ◽  
Isabelle Lacroix ◽  
...  
Keyword(s):  
Cohort Study ◽  
Population Based ◽  
In Utero ◽  
First Year ◽  
In Utero Exposure ◽  
First Year Of Life

scholarly journals Use of biologics during pregnancy and risk of serious infections in the mother and baby: a Canadian population-based cohort study

BMJ Open ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. e023714 ◽  
Author(s):  
Nicole W Tsao ◽  
Larry D Lynd ◽  
Eric C Sayre ◽  
Mohsen Sadatsafavi ◽  
Gillian Hanley ◽  
...  
Keyword(s):  
Cohort Study ◽  
Autoimmune Diseases ◽  
Disease Diagnosis ◽  
Population Based ◽  
In Utero ◽  
First Year ◽  
Increased Risk ◽  
Serious Infections ◽  
Multivariable Models ◽  
First Year Of Life

ObjectivesTo investigate the association between exposure to biologics during pregnancy and serious infections in mothers and infants.DesignRetrospective cohort study.SettingPopulation-based.ParticipantsWomen with one or more autoimmune diseases identified by International Classification of Diseases 9th/10th revision codes in healthcare administrative databases in British Columbia, Canada, who had pregnancies ending in a live or stillbirth between 1 January 2002 and 31 December 2012. Women were defined as exposed if they had at least one biologic prescription during pregnancy, and infants born to these women were considered exposed in utero. Disease-matched women with no biologics prescriptions during pregnancy, and their infants, comprised the unexposed groups.Primary outcome measuresSerious infections requiring hospitalisation.ResultsOver the 10-year study period, there were 6218 women (8607 pregnancies) who had an autoimmune disease diagnosis, of which 90 women were exposed to biologics during pregnancy, with 100 babies born to these women. Among women exposed to biologics during pregnancy, occurrence of serious postpartum infections were low, ranging from 0% to 5%, depending on concomitant exposures to immunosuppressants. In multivariable models using logistic regression, the OR for the association of biologics exposure with serious maternal postpartum infections was 0.79 (95% CI 0.24 to 2.54). In infants exposed to biologics in utero, occurrence of serious infections during the first year of life ranged from 0% to 7%, depending on concomitant exposures to immunosuppressants in utero. Multivariable models showed no association between biologics exposure in utero and serious infant infections (OR 0.56, 95% CI 0.17 to 1.81).ConclusionsThese population-based data suggest that the use of biologics by women with autoimmune diseases during pregnancy is not associated with an increased risk of serious infections in mothers, during post partum or in infants during the first year of life.

scholarly journals Acid-suppressive medications in the first year of life and risk of childhood asthma: a population-based birth cohort study

2020 ◽  
Vol 56 (5) ◽  
pp. 2000197 ◽  
Author(s):  
Claudio Barbiellini Amidei ◽  
Rosanna Comoretto ◽  
Loris Zanier ◽  
Daniele Donà ◽  
Anna Cantarutti ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Cohort ◽  
Childhood Asthma ◽  
Population Based ◽  
Birth Cohort Study ◽  
First Year ◽  
First Year Of Life

scholarly journals Postnatal growth in preterm infants during the first year of life: A population-based cohort study in China

PLoS ONE ◽  
2019 ◽  
Vol 14 (4) ◽  
pp. e0213762
Author(s):  
Leni Kang ◽  
Huiqing Wang ◽  
Chunhua He ◽  
Ke Wang ◽  
Lei Miao ◽  
...  
Keyword(s):  
Cohort Study ◽  
Preterm Infants ◽  
Postnatal Growth ◽  
Population Based ◽  
First Year ◽  
First Year Of Life

scholarly journals The Fetal Antibiotic EXposure (FAX) Study: Research on the Effect of in-utero antibiotic exposure on childhood outcomes (Preprint)

2018 ◽  
Author(s):  
Corinna Koebnick ◽  
Sara Y. Tartof ◽  
Margo A. Sidell ◽  
Emily Rozema ◽  
Joanie J Chung ◽  
...  
Keyword(s):  
In Utero ◽  
Autism Spectrum ◽  
Adverse Outcomes ◽  
First Year ◽  
In Utero Exposure ◽  
Study Cohort ◽  
Antibiotic Exposure ◽  
Real World Data ◽  
First Year Of Life ◽  
Over Time

BACKGROUND The widespread use of antepartum and intrapartum antibiotics has raised concerns about the possible disruption of the child's gut microbiota, and effects on the ‘maturation’ from the infant to the adult microbiome. The Fetal Antibiotic EXposure (FAX) Study provides a cohort to examine the association between in-utero exposure to antibiotics and adverse childhood outcomes including body weight, atopic diseases, and autism spectrum disorders and to investigate the role of other potential factors mitigating or moderating the risk for adverse outcomes. OBJECTIVE To describe the methods, cohort characteristics, and retention of infants included in the study cohort. METHODS For this retrospective cohort study, we included children born in KPSC hospitals between January 1, 2007 and December 31, 2015 within 22-44 weeks of gestation with KPSC insurance coverage during the first year of life. Follow-up data collection is through electronic medical record (EMR) data from Kaiser Permanente Southern California (KPSC). RESULTS The study cohort was comprised of 223,431 children of which 65.7% were exposed to antibiotics in-utero; 19.0% were exposed during the antepartum period, 30.0% during the intrapartum period, and 16.7% exposed during both the antepartum and intrapartum periods. During their first year of life, children had a median of 5 BMI measurements; the frequency of BMI measurements declined to a median of 3 in their second year of life and 2 for 3-5 years of age. The 5-year retention of children in the health plan was over 80% with the highest retention for Hispanic children. CONCLUSIONS This cohort of children will provide a unique opportunity to address key questions regarding the long-term sequelae of in-utero exposure to antibiotics using real-world data. The high retention and multiple medical visits over time allow us to model the trajectories of BMI over time.

Acute respiratory symptoms and general illness during the first year of life: A population-based birth cohort study

2008 ◽  
Vol 43 (6) ◽  
pp. 584-593 ◽  
Author(s):  
Marie-Louise von Linstow ◽  
Klaus Kähler Holst ◽  
Karina Larsen ◽  
Anders Koch ◽  
Per Kragh Andersen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Cohort ◽  
Respiratory Symptoms ◽  
Population Based ◽  
Birth Cohort Study ◽  
First Year ◽  
First Year Of Life

Antibiotic Exposure in the First Year of Life and the Risk of Attention-Deficit/Hyperactivity Disorder: A Population-Based Cohort Study

2019 ◽  
Vol 188 (11) ◽  
pp. 1923-1931 ◽  
Author(s):  
Amani F Hamad ◽  
Silvia Alessi-Severini ◽  
Salaheddin M Mahmud ◽  
Marni Brownell ◽  
I fan Kuo
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Cohort Study ◽  
Confidence Interval ◽  
Attention Deficit ◽  
Population Based ◽  
First Year ◽  
Antibiotic Exposure ◽  
Matched Cohort ◽  
Hyperactivity Disorder ◽  
First Year Of Life

Abstract Early childhood antibiotic exposure induces changes in gut microbiota reportedly associated with the development of attention-deficit/hyperactivity disorder (ADHD). We conducted a population-based cohort study to examine the association between antibiotic use in the first year of life and ADHD risk. We included children born in Manitoba, Canada, between 1998 and 2017. Exposure was defined as having filled 1 or more antibiotic prescriptions during the first year of life. ADHD diagnosis was identified in hospital abstracts, physician visits, or drug dispensations. Risk of developing ADHD was estimated using Cox proportional hazards regression in a high-dimensional propensity score–matched cohort (n = 69,738) and a sibling cohort (n = 67,671). ADHD risk was not associated with antibiotic exposure in the matched-cohort (hazard ratio = 1.02, 95% confidence interval: 0.97, 1.08) or in the sibling cohort (hazard ratio = 0.96, 95% confidence interval: 0.89, 1.03). In secondary analyses of the matched cohort, ADHD risk increase was observed in those exposed to 4 or more antibiotic courses or a duration longer than 3 weeks. These associations were not observed in the sibling cohort. We concluded that antibiotic exposure in the first year of life does not pose an ADHD risk on a population level.

scholarly journals Material community deprivation and hospital utilization during the first year of life: an urban population–based cohort study

2019 ◽  
Vol 30 ◽  
pp. 37-43 ◽  
Author(s):  
Cole Brokamp ◽  
Andrew F. Beck ◽  
Neera K. Goyal ◽  
Patrick Ryan ◽  
James M. Greenberg ◽  
...  
Keyword(s):  
Cohort Study ◽  
Urban Population ◽  
Population Based ◽  
Hospital Utilization ◽  
First Year ◽  
Material Community ◽  
First Year Of Life

Antibiotic exposure in the first year of life and later treated asthma, a population based birth cohort study of 143,000 children

2015 ◽  
Vol 31 (1) ◽  
pp. 85-94 ◽  
Author(s):  
Gisella Pitter ◽  
Jonas Filip Ludvigsson ◽  
Pierantonio Romor ◽  
Loris Zanier ◽  
Renzo Zanotti ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Cohort ◽  
Population Based ◽  
Birth Cohort Study ◽  
First Year ◽  
Antibiotic Exposure ◽  
First Year Of Life

scholarly journals Risk of early neurodevelopmental disorders associated with in utero exposure to valproate and other antiepileptic drugs: a nationwide cohort study in France

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Joël Coste ◽  
Pierre-Olivier Blotiere ◽  
Sara Miranda ◽  
Yann Mikaeloff ◽  
Hugo Peyre ◽  
...  
Keyword(s):  
Cohort Study ◽  
Antiepileptic Drugs ◽  
Neurodevelopmental Disorders ◽  
Speech Therapy ◽  
Population Based ◽  
In Utero ◽  
In Utero Exposure ◽  
Cox Proportional Hazard ◽  
Increased Risk ◽  
Cox Proportional Hazard Models

Abstract Information available on the risks of neurodevelopmental disorders (NDs) associated with in utero exposure to valproate (VPA) and to other antiepileptic drugs (AEDs) is limited. A nationwide population-based cohort study was conducted based on comprehensive data of the French National Health Data System (SNDS). Liveborn infants without brain malformation, born between January 2011 and December 2014, were followed from birth up to December 2016. NDs were identified based on diagnoses of mental or behavioural disorders and utilization of speech therapy, orthoptic or psychiatric services. The risk of NDs was compared between children exposed in utero to AED monotherapy and unexposed children, using Cox proportional hazard models adjusted for maternal and neonatal characteristics. The cohort included 1,721,990 children, 8848 of whom were exposed in utero to AED monotherapy. During a mean follow-up of 3.6 years, 15,458 children had a diagnosis of mental or behavioural disorder. In utero exposure to VPA was associated with an increased risk of NDs overall (aHR: 3.7; 95% CI 2.8–4.9) and among children born to a mother without mental illness (aHR 5.1; 95% CI 3.6–7.3). A dose–response relationship was demonstrated and the risk of NDs was more particularly increased for an exposure to VPA during the second or third trimesters of pregnancy. Among the other AEDs, only pregabalin was consistently associated with an increased risk of NDs (aHR: 1.5; 95% CI 1.0–2.1). This study confirms a four to fivefold increased risk of early NDs associated with exposure to VPA during pregnancy. The risk associated with other AEDs appears much lower.

Sign in / Sign up

Export Citation Format

Share Document