Segetoside I, a plant-derived bisdesmosidic saponin, induces apoptosis in human hepatoma cells in vitro and inhibits tumor growth in vivo

2016 ◽  
Vol 110 ◽  
pp. 101-110 ◽  
Author(s):  
Caleb Kesse Firempong ◽  
Hui Yun Zhang ◽  
Yan Wang ◽  
Jingjing Chen ◽  
Xia Cao ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells

scholarly journals Evaluation of an In vitro Approach to the Prediction of In vivo Effects on Multidrug Resistance in Human Hepatoma Cells

2018 ◽  
Vol 09 (02) ◽  
Author(s):  
Kosuke Inamura ◽  
Kazumi Emoto ◽  
Hideaki Ichihara ◽  
Kohei Sasaki ◽  
Takuya Iwasa ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
In Vivo Effects

Non-genomic action of TCDD to induce inflammatory responses in HepG2 human hepatoma cells and in liver of C57BL/6J mice

2010 ◽  
Vol 391 (10) ◽  
Author(s):  
Wen Li ◽  
Christoph F.A. Vogel ◽  
Dalei Wu ◽  
Fumio Matsumura
Keyword(s):  
Hepg2 Cells ◽  
Inflammatory Responses ◽  
Hepatoma Cells ◽  
Cytokine Signaling ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Classical Action ◽  
Cox 2

Abstract To assess the significance of the non-genomic signaling of TCDD (=dioxin) on liver of C57BL/6 mice and HepG2 human hepatoma cells, we first determined the group of markers that are susceptible to inhibition by parthenolide, a compound known to specifically suppress NF-κB-mediated inflammation. Of those, the most consistent marker turned out to be SOCS3 (a suppressor of cytokine signaling) known to respond to inflammation. An early diagnostic test on the action of TCDD on HepG2 cells in vitro within 3–6 h indicated that Cox-2 and SOCS3 are mainly induced via a non-genomic route, whereas PAI-2 appears to be induced through the classical action route. More detailed diagnostic tests at later stages of action of TCDD in HepG2 cells revealed that induction of IL-1β, BAFF, and iNOS are largely mediated by the protein kinase-dependent non-genomic route. An in vivo study on the 7 day action of TCDD on liver of AhRNLS mice showed that several early markers (e.g., Cox-2, MCP-1 and SOCS3) are induced, but not late markers such as IL-1β. Together, these results show that the non-genomic pathway contributes significantly to the early stress response reactions to TCDD that includes inflammation in hepatoma cells as well as in the liver.

Anti-proliferative activity of fenretinide in human hepatoma cells in vitro and in vivo

2007 ◽  
Vol 18 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Jianzhong Shentu ◽  
Bo Zhang ◽  
Lingling Fan ◽  
Qioajun He ◽  
Bo Yang ◽  
...  
Keyword(s):  
Proliferative Activity ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells

scholarly journals Gli2 silencing enhances TRAIL-induced apoptosis and reduces tumor growth in human hepatoma cells in vivo

2014 ◽  
Vol 15 (12) ◽  
pp. 1667-1676 ◽  
Author(s):  
Da-wei Zhang ◽  
Hai-yan Li ◽  
Wan-yee Lau ◽  
Liang-qi Cao ◽  
Yue Li ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Induced Apoptosis

scholarly journals Earthworm fibrinolytic enzyme: anti-tumor activity on human hepatoma cells in vitro and in vivo

2007 ◽  
Vol 120 (10) ◽  
pp. 898-904 ◽  
Author(s):  
Hong CHEN ◽  
Shoichi Takahashi ◽  
Michio Imamura ◽  
Eiko Okutani ◽  
Zhi-guo ZHANG ◽  
...  
Keyword(s):  
Hepatoma Cells ◽  
Fibrinolytic Enzyme ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Earthworm Fibrinolytic Enzyme ◽  
Anti Tumor Activity

scholarly journals Cyclooxygenase-2 inhibitor and interferon-β synergistically induce apoptosis in human hepatoma cells in vitro and in vivo

2006 ◽  
Author(s):  
Nobuhiro Nakamoto ◽  
Hajime Higuchi ◽  
Hideaki Kanamori ◽  
Satoshi Kurita ◽  
Shinichiro Tada ◽  
...  
Keyword(s):  
Hepatoma Cells ◽  
Cyclooxygenase 2 ◽  
Human Hepatoma ◽  
Interferon Β ◽  
Human Hepatoma Cells
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