scholarly journals Comparison of time curves from dynamic 18F-fluciclovine positron emission tomography and dynamic contrast-enhanced magnetic resonance imaging for primary prostate carcinomas

2018 ◽  
Vol 7 ◽  
pp. 51-57 ◽  
Author(s):  
Andreas Julius Tulipan ◽  
Ljiljana Vlatkovic ◽  
Eirik Malinen ◽  
Bjørn Brennhovd ◽  
Knut Håkon Hole ◽  
...  
2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Jacob U. Fluckiger ◽  
Xia Li ◽  
Jennifer G. Whisenant ◽  
Todd E. Peterson ◽  
John C. Gore ◽  
...  

We show how dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data can constrain a compartmental model for analyzing dynamic positron emission tomography (PET) data. We first develop the theory that enables the use of DCE-MRI data to separate whole tissue time activity curves (TACs) available from dynamic PET data into individual TACs associated with the blood space, the extravascular-extracellular space (EES), and the extravascular-intracellular space (EIS). Then we simulate whole tissue TACs over a range of physiologically relevant kinetic parameter values and show that using appropriate DCE-MRI data can separate the PET TAC into the three components with accuracy that is noise dependent. The simulations show that accurate blood, EES, and EIS TACs can be obtained as evidenced by concordance correlation coefficients >0.9 between the true and estimated TACs. Additionally, provided that the estimated DCE-MRI parameters are within 10% of their true values, the errors in the PET kinetic parameters are within approximately 20% of their true values. The parameters returned by this approach may provide new information on the transport of a tracer in a variety of dynamic PET studies.


2020 ◽  
Vol 22 (4) ◽  
pp. 485
Author(s):  
Yonggeng Goh ◽  
Eric Ting ◽  
Jeevesh Kapur ◽  
Melati Dewi ◽  
Arvind Kumar Sinha ◽  
...  

This case report demonstrates the potential of contrast-enhanced ultrasound (CEUS) in diagnosing active arterial wall inflammation in a symptomatic patient with Takayasu arteritis (TA). To our knowledge, this is the first case which demonstrates pictorial correlation of arterial wall neovascularity on CEUS with mural edema on magnetic resonance imaging and metabolic activity on positron emission tomography – computed tomography in the same patient. As TA is a chronic disease which requires long-term follow-up, CEUS could be the potential imaging modality of choice as it is radiation-free, non-nephrotoxic and easily available.


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