scholarly journals A magnetic resonance imaging-based approach to quantify radiation-induced normal tissue injuries applied to trismus in head and neck cancer

2017 ◽  
Vol 1 ◽  
pp. 34-40 ◽  
Author(s):  
Maria Thor ◽  
Neelam Tyagi ◽  
Vaios Hatzoglou ◽  
Aditya Apte ◽  
Ziad Saleh ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Head And Neck Cancer ◽  
Magnetic Resonance ◽  
Head And Neck ◽  
Neck Cancer ◽  
Normal Tissue ◽  
Resonance Imaging ◽  
Radiation Induced ◽  
Tissue Injuries

scholarly journals Magnetic resonance imaging of the carotid artery in long-term head and neck cancer survivors treated with radiotherapy

2015 ◽  
Vol 54 (8) ◽  
pp. 1175-1180 ◽  
Author(s):  
Joyce Wilbers ◽  
Frederick J. A. Meijer ◽  
Arnoud C. Kappelle ◽  
Johannes H. Kaanders ◽  
Willem Boogerd ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Head And Neck Cancer ◽  
Magnetic Resonance ◽  
Carotid Artery ◽  
Cancer Survivors ◽  
Head And Neck ◽  
Neck Cancer ◽  
Resonance Imaging

scholarly journals Photoacoustic and Magnetic Resonance Imaging of Hybrid Manganese Dioxide-Coated Ultra-Small NaGdF4 Nanoparticles for Spatiotemporal Modulation of Hypoxia in Head and Neck Cancer

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3294
Author(s):  
Laurie J. Rich ◽  
Jossana A. Damasco ◽  
Julia C. Bulmahn ◽  
Hilliard L. Kutscher ◽  
Paras N. Prasad ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Head And Neck Cancer ◽  
Magnetic Resonance ◽  
Head And Neck ◽  
Manganese Dioxide ◽  
Neck Cancer ◽  
Tumor Hypoxia ◽  
Tumor Oxygenation ◽  
Hybrid Nanoparticles ◽  
Resonance Imaging

There is widespread interest in developing agents to modify tumor hypoxia in head and neck squamous cell carcinomas (HNSCC). Here, we report on the synthesis, characterization, and potential utility of ultra-small NaYF4:Nd3+/NaGdF4 nanocrystals coated with manganese dioxide (usNP-MnO2) for spatiotemporal modulation of hypoxia in HNSCC. Using a dual modality imaging approach, we first visualized the release of Mn2+ using T1-weighted magnetic resonance imaging (MRI) and modulation of oxygen saturation (%sO2) using photoacoustic imaging (PAI) in vascular channel phantoms. Combined MRI and PAI performed in patient-derived HNSCC xenografts following local and systemic delivery of the hybrid nanoparticles enabled mapping of intratumoral nanoparticle accumulation (based on T1 contrast enhancement) and improvement in tumor oxygenation (increased %sO2) within the tumor microenvironment. Our results demonstrate the potential of hybrid nanoparticles for the modulation of tumor hypoxia in head and neck cancer. Our findings also highlight the potential of combined MRI-PAI for simultaneous mapping nanoparticle delivery and oxygenation changes in tumors. Such imaging methods could be valuable in the precise selection of patients that are likely to benefit from hypoxia-modifying nanotherapies.

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