scholarly journals Prevalence of malaria and performance of a rapid diagnostic test for malaria in febrile children with sickle cell disease

2018 ◽  
Vol 3 (2) ◽  
pp. 42-45 ◽  
Author(s):  
Hannah O. Dada-Adegbola ◽  
Biobele J. Brown ◽  
Adeyemi A. Labaeka
Keyword(s):  
Sickle Cell Disease ◽  
Diagnostic Test ◽  
Rapid Diagnostic Test ◽  
Sickle Cell ◽  
Cell Disease ◽  
And Performance

scholarly journals Evaluation of a Density-Based Rapid Diagnostic Test for Sickle Cell Disease in a Clinical Setting in Zambia

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e114540 ◽  
Author(s):  
Ashok A. Kumar ◽  
Catherine Chunda-Liyoka ◽  
Jonathan W. Hennek ◽  
Hamakwa Mantina ◽  
S. Y. Ryan Lee ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Diagnostic Test ◽  
Rapid Diagnostic Test ◽  
Sickle Cell ◽  
Clinical Setting ◽  
Cell Disease

Initial Clinical Validation of a Rapid, Low-Cost, Paper-Based Diagnostic Test for Sickle Cell Anemia As a Tool to Facilitate Newborn Screening in Resource-Limited Settings

Blood ◽  
2015 ◽  
Vol 126 (23) ◽  
pp. 979-979
Author(s):  
Nathaniel Z. Piety ◽  
Alex George ◽  
Sonia Serrano ◽  
Maria Rosa Lanzi ◽  
Palka R. Patel ◽  
...  
Keyword(s):  
High Risk ◽  
Sickle Cell Disease ◽  
Newborn Screening ◽  
Diagnostic Test ◽  
Sickle Cell ◽  
Rapid Test ◽  
Cell Disease ◽  
Blood Samples ◽  
Resource Limited ◽  
Application Paper

Abstract Newborn screening for sickle cell disease (SCD) in developing countries is limited by the cost and technical complexity of current screening methodologies and the delayed availability of screening results. We have recently developed a rapid diagnostic test for SCD that can quickly and inexpensively identify blood samples containing hemoglobin S. We hypothesized that our rapid test would be practical for use in a resource-limited setting in Cabinda, Angola, and that screening mothers or neonates for the presence of hemoglobin S in blood samples would be an effective means of identifying neonates at high risk of having sickle cell disease prior to more definitive testing. After informed consent, we collected blood samples heel-stick from neonates and by finger-stick from mothers at the primary obstetric hospital in Cabinda. We then tested these samples by the rapid SCD test and scored them by visual assessment of staining patterns. Neonates were scored as positive (HbS detected) or negative (no HbS detected) and mothers as AA, AS (sickle trait), or SS (sickle cell disease). Neonatal samples were subsequently tested by isoelectric focusing (IEF) electrophoresis to determine exact sickle cell status. In a cohort of 133 mother-neonate pairs, we used rapid testing on maternal samples to categorize neonates as high-risk (mother positive for HbS) or low-risk (mother negative for HbS). The rapid test was highly accurate in identifying neonates who could be excluded from IEF testing, with a negative predictive value of 93% (Figure 1). In a cohort of 95 neonates similarly triaged by rapid testing on neonatal samples, the negative predictive value of the test was 96% (Figure 2). In both cohorts, the one neonate with HbSS disease was successfully triaged into the high-risk group. Maternal screening with the rapid test would have reduced the proportion of neonates requiring confirmatory IEF testing to 19%, while neonatal screening would have reduced this proportion to 26%. These results indicate the potential utility of the rapid diagnostic test as a screening tool prior to more definitive testing. Used in combination with confirmatory IEF, our rapid test could significantly decrease the cost of newborn screening for SCD and increase its clinical utility by permitting more rapid identification of affected infants. Disclosures Piety: Halcyon Biomedical: Patents & Royalties: Mr. Piety is a co-inventor on a utility PCT application, "Paper-based diagnostic test" (PCT/US2012/064856, 11/13/2012), claiming priority benefit of U.S. 61/692,994 (8/24/2012) and U.S. 61/558,009 (11/10/2011). . Shevkoplyas:Halcyon Biomedical: Equity Ownership, Patents & Royalties: Co-inventor on a utility PCT application, "Paper-based diagnostic test" (PCT/US2012/064856, 11/13/2012), claiming priority benefit of U.S. 61/692,994 (8/24/2012) and U.S. 61/558,009 (11/10/2011). Part-owner of Halcyon Biomedical Inc.,.

A simple, rapid, low-cost diagnostic test for sickle cell disease

Lab on a Chip ◽  
2013 ◽  
Vol 13 (8) ◽  
pp. 1464 ◽  
Author(s):  
Xiaoxi Yang ◽  
Julie Kanter ◽  
Nathaniel Z. Piety ◽  
Melody S. Benton ◽  
Seth M. Vignes ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Diagnostic Test ◽  
Sickle Cell ◽  
Low Cost ◽  
Cell Disease

Hemolysis in sickle cell disease

1974 ◽  
Vol 133 (4) ◽  
pp. 624-631 ◽  
Author(s):  
T. A. Bensinger
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease

Computerized cognitive training in pediatric sickle cell disease: A randomized controlled pilot study.

2020 ◽  
Vol 8 (4) ◽  
pp. 390-401 ◽  
Author(s):  
Taryn M. Allen ◽  
Lindsay M. Anderson ◽  
Samuel M. Brotkin ◽  
Jennifer A. Rothman ◽  
Melanie J. Bonner
Keyword(s):  
Pilot Study ◽  
Sickle Cell Disease ◽  
Cognitive Training ◽  
Sickle Cell ◽  
Cell Disease ◽  
Computerized Cognitive Training ◽  
Randomized Controlled ◽  
Pediatric Sickle Cell Disease
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