Long-term stability of temocillin in dextrose 5% and in sodium chloride 0.9% polyolefin bags at 5±3°C after freeze-thaw treatment

2011 ◽  
Vol 69 (6) ◽  
pp. 296-301 ◽  
Author(s):  
C. Rolin ◽  
J.-D. Hecq ◽  
P. Tulkens ◽  
D. Vanbeckbergen ◽  
J. Jamart ◽  
...  
Keyword(s):  
Sodium Chloride ◽  
Freeze Thaw ◽  
Term Stability ◽  
Long Term Stability

scholarly journals Long-Term Stability of 5-Fluorouracil in 0.9% Sodium Chloride after Freezing, Microwave Thawing, and Refrigeration

2009 ◽  
Vol 62 (1) ◽  
Author(s):  
Laurence Galanti ◽  
Massin P Lebitasy ◽  
Jean-Daniel Hecq ◽  
Julie Cadrobbi ◽  
Danielle Vanbeckbergen ◽  
...  
Keyword(s):  
Sodium Chloride ◽  
Term Stability ◽  
Long Term Stability

scholarly journals Long-term stability of sufentanil citrate with levobupivacaine hydrochloride in 0.9% sodium chloride infusion PVC bags at 4° C

2004 ◽  
Vol 28 (1) ◽  
pp. 4-6 ◽  
Author(s):  
Laurence Boitquin ◽  
Jean-Daniel Hecq ◽  
Jean-Michel Evrard ◽  
Danielle Vanbeckbergen ◽  
Jacques Jamart ◽  
...  
Keyword(s):  
Sodium Chloride ◽  
Term Stability ◽  
Long Term Stability

Freeze-thaw stability and long-term stability of 84 synthetic cannabinoids in serum

2016 ◽  
Vol 9 (10) ◽  
pp. 1506-1511 ◽  
Author(s):  
Cornelius Hess ◽  
Lynn Krueger ◽  
Michael Unger ◽  
Burkhard Madea
Keyword(s):  
Synthetic Cannabinoids ◽  
Freeze Thaw ◽  
Term Stability ◽  
Long Term Stability

Long-term stability of dexamethasone and alizapride or ondansetron in sodium chloride 0.9% polyolefin bag at 5±3°C

2017 ◽  
Vol 75 (1) ◽  
pp. 30-39
Author(s):  
J. Simar ◽  
M. Godet ◽  
J.-D. Hecq ◽  
M. Closset ◽  
P. Gillet ◽  
...  
Keyword(s):  
Sodium Chloride ◽  
Term Stability ◽  
Long Term Stability

Long term stability of an admixture of alizapride and ondansetron in 0.9% sodium chloride solution polyolefin bags stored at 5±3°C

2020 ◽  
pp. 107815522095044
Author(s):  
Mélanie Closset ◽  
Nicolas Goderniaux ◽  
Marie-Lise Colsoul ◽  
Laura Soumoy ◽  
Benoit Bihin ◽  
...  
Keyword(s):  
Sodium Chloride ◽  
Chloride Solution ◽  
High Performance ◽  
Sodium Chloride Solution ◽  
Physical Stability ◽  
Uv Detector ◽  
Term Stability ◽  
Long Term Stability ◽  
Aseptic Conditions

Background Patients undergoing chemotherapeutic treatment are currently treated by a concomittent infusion of alizapride and ondansetron. To optimise the procedure and to ensure patients’ safety, the admixture could be prepared in advance by the Centralized Intravenous Additive Service (CIVAS) provided that the stability of the mixture has been proven beforhand to reduce nausea and vomiting. Aim of the study: to evaluate the long-term stability of an admixture of alizapride 0.926 mg/l and ondansetron 0.074 mg/ml in 0.9% sodium chloride polyolefin bags stored at 5 ± 3°C. Material and methods Five polyolefin bags containing 100 ml sodium chloride 0.9% added with 4 ml alizapride (100 mg) and 4 ml ondansetron (8 mg) were prepared in aseptic conditions and stored at 5 ± 3°C for 56 days. Periodically, physical stability tests were performed including: pH measurements, optical density measurements at 350, 410 and 550 nm to track turbidity appearance, visual and microscopical inspections to detect colour changes, precipitation, microaggregates or crystals. The concentrations of the solutions were measured by High Performance Liquid Chromatography coupled with an UV detector. Results There was no change in pH and optical densities during the study period. Visual and microscopical inspections didn’t show any change of colour neither precipitation, microaggregate or crystal. The alizapride and ondansetron concentrations remained stable over the study. Conclusion The admixture of alizapride and ondansetron in 0.9% sodium chloride solution polyolefin bags is physicochemically stable up to 56 days at 5 ± 3°C. These results support the possibility of preparing the solutions in advance by a CIVAS.

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