Evaluation of a train-the-trainer program for stable coronary artery disease management in community settings: A pilot study

2018 ◽  
Vol 101 (2) ◽  
pp. 256-265 ◽  
Author(s):  
Zhiyun Shen ◽  
Changying Jiang ◽  
Liqun Chen
2020 ◽  
Vol 9 (2) ◽  
pp. 493-503 ◽  
Author(s):  
Naveen Seecheran ◽  
Brent Boodhai ◽  
Aarti Maharaj ◽  
Arvinash Ramdeen ◽  
Niranjan Debideen ◽  
...  

2013 ◽  
Vol 5 (1) ◽  
pp. 86 ◽  
Author(s):  
Faouzi Addad ◽  
Majdi Amami ◽  
Nadia Hammami ◽  
Sami Gargouri ◽  
Sonia Marrakchi ◽  
...  

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Wiktor Kuliczkowski ◽  
Marek Radomski ◽  
Mariusz Gąsior ◽  
Joanna Urbaniak ◽  
Jacek Kaczmarski ◽  
...  

Background. High on-aspirin treatment platelets reactivity (HPR) is a significant problem in long-term secondary prevention of cardiovascular events. We hypothesize that imbalance between platelets MMPs/TIMPs results in cardiovascular disorders. We also explored whether chronically elevated blood glucose affects MMP-2/TIMP-4 release from platelets. Materials and Methods. Seventy patients with stable coronary artery disease, supplemented with aspirin, participated in this pilot study. The presence of HPR and/or diabetes mellitus was considered as the differentiating factor. Light aggregometry, impedance aggregometry, and ELISA tests for TXB2, MMP-2, MMP-9, and TIMP-4 were performed in serum, plasma, platelet-rich plasma, and platelets-poor plasma, as appropriate. Results. Aspirin-HPR did not affect plasma MMP-2, MMP-9, and TIMP-4. Arachidonic acid-induced aggregation of platelets from aspirin-HPR patients did not lead to increased release of MMP-2, MMP-9, and TIMP-4. Studying patients at the lowest TXB2 serum concentration quartile revealed that high concentration of plasma TIMP-4 and TIMP-4 negatively correlated with TXB2 and platelet aggregation. Diabetics showed an increased plasma MMP-2 as well as an increased MMP-2 in supernatants after platelet aggregation. However, diabetes mellitus did not affect MMP-9 and TIMP-4. Conclusion. Aspirin-HPR did not affect the translocation and release of MMPs and TIMP-4 from platelets. TIMP-4 may serve as a marker of TXA2-mediated platelet aggregation. Chronically elevated plasma glucose increases plasma MMP-2, and HPR potentiates this phenomenon.


Diabetes ◽  
1997 ◽  
Vol 46 (9) ◽  
pp. 1491-1496 ◽  
Author(s):  
M. Maki ◽  
P. Nuutila ◽  
H. Laine ◽  
L. M. Voipio-Pulkki ◽  
M. Haaparanta ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document