The impact of genetic counseling on knowledge and emotional responses in Spanish population with family history of breast cancer

2010 ◽  
Vol 78 (3) ◽  
pp. 382-388 ◽  
Author(s):  
Esther Cabrera ◽  
Ignacio Blanco ◽  
Carmen Yagüe ◽  
Adelaida Zabalegui
Keyword(s):  
Breast Cancer ◽  
Genetic Counseling ◽  
Family History ◽  
Emotional Responses ◽  
Spanish Population ◽  
History Of ◽  
The Impact

scholarly journals Mortality and Risk of Cancer After Prophylactic Bilateral Oophorectomy in Women With a Family History of Cancer

2018 ◽  
Vol 2 (3) ◽  
Author(s):  
Julie Abildgaard ◽  
Magnus Glindvad Ahlström ◽  
Gedske Daugaard ◽  
Dorte Lisbet Nielsen ◽  
Anette Tønnes Pedersen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Rate Ratio ◽  
Bilateral Oophorectomy ◽  
Family History Of Cancer ◽  
Increased Risk ◽  
History Of ◽  
Risk Of Cancer ◽  
The Impact ◽  
History Of Cancer

Abstract Background Current international guidelines recommend systemic hormone therapy (HT) to oophorectomized women until the age of natural menopause. Despite an inherited predisposition to estrogen-dependent malignancies, the guidelines also apply to women oophorectomized because of a family history of cancer. The objective of this study was to investigate the impact of HT on mortality and risk of cancer in women oophorectomized because of a family history of cancer. Methods A nationwide, population-based cohort was used to study women oophorectomized because of a family history of cancer (n = 2002). Comparison cohorts included women from the background population individually matched on age (n = 18 018). Oophorectomized women were subdivided into three groups: oophorectomized at 1) age 45 years or younger not using HT, 2) age 45 years or younger using HT, 3) older than age 45 years, and their respective population comparison cohorts. Results Women oophorectomized at age 45 years or younger using HT had increased overall mortality (mortality rate ratio [MRR] = 3.45, 95% confidence interval [CI] = 1.53 to 7.79), mortality because of cancer (MRR = 5.67, 95% CI = 1.86 to 17.34), and risk of overall cancer (incidence rate ratio [IRR] = 3.68, 95% CI = 1.93 − 6.98), primarily reflected in an increased risk of breast cancer (IRR = 4.88, 95% CI = 2.19 − 10.68). Women oophorectomized at age 45 years or younger not using HT and women oophorectomized at older than age 45 years did not have increased mortality, mortality because of cancer, or risk of overall cancer, but they had increased risk of breast cancer (IRR = 2.64, 95% CI = 1.14 to 6.13, and IRR = 1.72, 95% CI = 1.14 to 2.59, respectively). Conclusions Use of HT in women oophorectomized at age 45 years or younger with a family history of cancer is associated with increased mortality and risk of overall cancer and breast cancer. Our study warrants further investigation to establish the impact of HT on mortality and cancer risk in oophorectomized women with a family history of cancer.

scholarly journals The Impact of Family History of Breast Cancer on Knowledge, Attitudes, and Early Detection Practices of Mexican Women Along the Mexico-US Border

2010 ◽  
Vol 13 (5) ◽  
pp. 867-875 ◽  
Author(s):  
Yelena Bird ◽  
Matthew P. Banegas ◽  
John Moraros ◽  
Sasha King ◽  
Surasri Prapasiri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Early Detection ◽  
Mexican Women ◽  
History Of ◽  
The Impact

The Impact of a Family History of Breast Cancer on Screening Practices and Attitudes in Low-Income, Rural, African American Women

2003 ◽  
Vol 12 (8) ◽  
pp. 779-787 ◽  
Author(s):  
Delia Smith West ◽  
Paul G. Greene ◽  
Polly P. Kratt ◽  
Leavonne Pulley ◽  
Heidi L. Weiss ◽  
...  
Keyword(s):  
Breast Cancer ◽  
African American ◽  
Family History ◽  
African American Women ◽  
Low Income ◽  
American Women ◽  
Screening Practices ◽  
History Of ◽  
The Impact

scholarly journals The impact of information given to patients’ families: Breast cancer risk notification

2012 ◽  
Vol 20 (1) ◽  
pp. 27-34
Author(s):  
Estrella Durá Ferrandis ◽  
Yolanda Andreu ◽  
Maria José Galdón
Keyword(s):  
Breast Cancer ◽  
At Risk ◽  
Family History ◽  
Health Beliefs ◽  
Close Relative ◽  
Screening Methods ◽  
First Degree Relatives ◽  
Preventive Practices ◽  
History Of ◽  
The Impact

A family history of breast cancer is a clear risk for developing the disease. Therefore, when a woman is diagnosed with breast cancer all her female first degree relatives become population at risk. This involve a number of important aspects to be taken into account by psychooncology professionals. (a) First, in addition to the stress associated with the diagnosis and treatment of breast cancer in a close relative, first degree relatives of breast cancer patients have the added stress of learning that they are at risk of this disease. (b) Second, these women become the main target of secondary breast cancer prevention strategies. However, various reports show that a considerable percentage of these women do not follow the recommended screening methods. For this reason, it is necessary to study the possible contribution of psychosocial factors, specially health beliefs, in the practice of preventive behavior aimed at preventing breast cancer in this population, and to design strategies to promote preventive practices. (c) Most of the research on health beliefs among women at risk for breat cancer has focused on risk perception.This research as found that some women with a family history of breast cancer have significantly overestimated their risk, while other shave underestimated their risk. The need to provide risk counselling schemes for these women is therefore proposed, in order to estimate and advise them of their real risk. (d) Finally, these women may request genetic testing to determine whether they carry genetic mutations (BRCA1, BRCA2, or others) that cause some types of breast cancer. However, it must be remembered that, although many first degree relatives will have heard of and seek «the cancer gene test», currently testing is appropiate and available only for rare individuals. All these issues are reviewed in the present paper.

Predictors of contralateral prophylactic mastectomy among patients with ductal carcinoma in situ (DCIS) who underwent evaluation for BRCA genetic testing.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 1549-1549
Author(s):  
Nisreen Elsayegh ◽  
Angelica M. Gutierrez-Barrera ◽  
Kimberly I. Muse ◽  
Heather Lin ◽  
Diana L. Turco ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Counseling ◽  
Family History ◽  
Tumor Markers ◽  
Prophylactic Mastectomy ◽  
Contralateral Prophylactic Mastectomy ◽  
Educational Status ◽  
Nuclear Grade ◽  
Factors Associated ◽  
History Of

1549 Background: Patients with DCIS are at increased risk for developing contralateral breast cancer (CBC). Therefore, an increasing number of women with DCIS are electing for contralateral prophylactic mastectomy (CPM). In a previous study involving 2072 women with DCIS, 13.5% chose CPM. In this study, we aimed to evaluate factors associated with CPM in patients with DCIS who underwent genetic counseling for BRCA. Methods: 165 women with pure DCIS, who underwent genetic counseling, were included in the study. Patients’ characteristics were obtained from a prospectively maintained research database at UT M.D. Anderson Cancer Center. Univariate and multivaraite logistic regression analysis were used to determine predictive factors associated with CPM. Patients’ characteristics included age, marital and educational status, tumor markers, nuclear grade, family history with breast (BC) and ovarian cancer (OC), race, Ashkenazi Jewish ancestry, and BRCA genetic test results. Results: Out of 165 patients, 17(10.3%) were found to have a BRCA deleterious mutation. 44(26.7%) underwent CPM. Younger patients (median ≤ 45 yr) were more likely to elect for CPM than older patients (p= 0.0098). Patients who tested positive for a BRCA mutation were more likely to elect for CPM than those who tested negative or were not tested (p= 0.0001). Patients who had a family history of OC (15 (57.7%) were more likely to choose CPM than those who did not (p= 0.0004). These three factors remained significant in the multivariate model (p <0.008). Marital and educational status, tumor markers, nuclear grade, and family history of breast cancer were not significant predictors of CPM. Conclusions: The rate of CPM in patients with DCIS is high. Factors associated with increased likelihood of undergoing CPM include family history of OC, age, and BRCA positivity. Further studies are needed to evaluate patients perception of CBC risk, and if this may play a role in the high number of CPM.

scholarly journals The impact of genetic counselling on risk perception and mental health in women with a family history of breast cancer

1999 ◽  
Vol 79 (5-6) ◽  
pp. 868-874 ◽  
Author(s):  
M Watson ◽  
S Lloyd ◽  
J Davidson ◽  
L Meyer ◽  
R Eeles ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mental Health ◽  
Risk Perception ◽  
Family History ◽  
Genetic Counselling ◽  
History Of ◽  
The Impact

Genetic counseling for women with an intermediate family history of breast cancer

2000 ◽  
Vol 90 (5) ◽  
pp. 361-368 ◽  
Author(s):  
Wylie Burke ◽  
Julie O. Culver ◽  
Deborah Bowen ◽  
Diana Lowry ◽  
Sharon Durfy ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Counseling ◽  
Family History ◽  
History Of
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